Results 61 to 70 of about 245,801 (303)

Relationships of Total Lymphocyte Count and Subpopulation Lymphocyte Counts with the Nutritional Status in Patients Undergoing Hemodialysis/Peritoneal Dialysis [PDF]

Kosin Medical Journal, 2017
ObjectivesDialysis patients’ nutritional indicators are quite subjective and complex and cannot be easily measured in clinical settings. Based on previous reports that total lymphocyte count (TLC) and subpopulation lymphocyte counts (SLCs) are associated
Ye Na Kim, Ho Sik Shin
doaj   +1 more source

CD4+ T-Lymphocyte Count/CD8+ T-Lymphocyte Count Ratio: Surrogate for HIV Infection in Infants? [PDF]

Journal of Tropical Pediatrics, 2012
Early diagnosis and treatment is necessary to prevent HIV-infected infants progressing to AIDS. Antibody testing is not confirmatory before the age of 18 months and PCR not widely available in resource-poor settings. We studied the accuracy of CD4(+) T-lymphocyte count, CD4% and CD4/CD8 ratio as surrogate markers of infant HIV infection.Two hundred and
Navaneethapandian, P. G. D., Karunaianantham, R., Subramanyan, S., Chinnayan, P., Chandrasekaran, P., Swaminathan, S.   +5 more
openaire   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

National Institute of Health Stroke Scale Score Mediated the Relationship between Systemic Inflammatory Response Index, High-Sensitivity C-Reactive Protein, and Functional Prognosis of Acute Ischemic Stroke: A Prospective Cross-Sectional Study

Heart and Mind
Background: The systemic inflammatory indicators were reported to relate to the functional prognosis of acute ischemic stroke (AIS). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII ...
Xueqing Liu, Tong Zhang, Liqin Yang, Guojuan Chen, Peng Ding, Delin Yu, Haibing Liao, Jing Liu, Wei Yue   +8 more
doaj   +1 more source

The Relationship of Total Lymphocyte Count to CD4 Lymphocyte Counts in Patients Infected with Human Immunodeficiency Virus

The American Journal of the Medical Sciences, 1992
A simple, inexpensive alternative to CD4 counts would facilitate the management of asymptomatic and early symptomatic patients with HIV infection. In this report, a high correlation was found between CD4 counts and total lymphocyte counts calculated from complete blood counts in a cohort of ambulatory HIV-infected patients.
A M, Fournier, J M, Sosenko
openaire   +2 more sources

Antiretroviral treatment cohort analysis using time-updated CD4 counts: assessment of bias with different analytic methods. [PDF]

, 2011
BACKGROUND: Survival analysis using time-updated CD4+ counts during antiretroviral therapy is frequently employed to determine risk of clinical events.
Lewis, James J, Judith R. Glynn, Richard G White, James J Lewis, Middelkoop, Keren, Glynn, Judith R., Glynn, Judith R, Stephen D. Lawn, White, Richard G, Katharina Kranzer, Linda-Gail Bekker, James J. Lewis, White, Richard G., Lawn, Stephen D., Lawn, Stephen D, Judith R Glynn, Robin Wood, Lewis, James J., Bekker, Linda-Gail, Stephen D Lawn, Kranzer, Katharina, Richard G. White, Wood, Robin, Keren Middelkoop   +23 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Investigation of Laboratory Parameters That Differentiate Complicated Appendicitis from Simple Appendicitis in Adults

İstanbul Medical Journal, 2019
Introduction:Acute appendicitis is one of the most common abdominal emergencies. In this study, we aimed to investigate preoperative laboratory parameters in patients with simple and complicated appendicitis.Methods:The medical records of patients over ...
Özgür Dikme, Özlem Dikme
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Early decrease in blood lymphocyte count is associated with poor prognosis in COVID-19 patients: a retrospective cohort study

BMC Pulmonary Medicine, 2023
Background Previous studies have declared that baseline lymphocyte count is associated with COVID-19-related death. However, whether dynamic lymphocyte change over time affects prognosis in COVID-19 patients is unknown. This study aims to investigate the
Gong Chen, Xiaofang Zhao, Xinglin Chen, Chengyun Liu   +3 more
doaj   +1 more source