Results 71 to 80 of about 333,907 (356)

Early decrease in blood lymphocyte count is associated with poor prognosis in COVID-19 patients: a retrospective cohort study

BMC Pulmonary Medicine, 2023
Background Previous studies have declared that baseline lymphocyte count is associated with COVID-19-related death. However, whether dynamic lymphocyte change over time affects prognosis in COVID-19 patients is unknown. This study aims to investigate the
Gong Chen, Xiaofang Zhao, Xinglin Chen, Chengyun Liu   +3 more
doaj   +1 more source

Quantifying tumour-infiltrating lymphocyte subsets : a practical immuno-histochemical method [PDF]

, 2007
Background: Efficient histological quantification of tumour-infiltrating T and B lymphocyte (TIL) subsets in archival tissues would greatly facilitate investigations of the role of TIL in human cancer biology. We sought to develop such a method. Methods:
Alison J. Gray, Bland, Brey, David I. Stott, Guillery, Hussein, Hussein, James J. Going, Liyanage, Matkowskyj, Mufson, Paula M. Loughlin, Poynton, Royet, Ruifrok, Sangwine, Timothy G. Cooke, von Bartheld, W. David George, Willimsky   +19 more
core   +1 more source

Pretreatment Absolute Lymphocyte Count and Neutrophil-to-lymphocyte Ratio Are Prognostic Factors for Stage III Breast Cancer [PDF]

, 2021
Kosho Yamanouchi, Shigeto Maeda, Daiki Takei, Yoichi Koga, Manpei Yamashita, Takashi Hamada, Takanori Hirayama, Akira Yoneda, Takayuki Tokunaga, Hiroaki Takeshita, Tamotsu Kuroki   +10 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Evaluation of Hemogram Indices of Children with Epilepsy Receiving Short-Term Levetiracetam Treatment

Archives of Epilepsy, 2022
Objective:The effects of levetiracetam on hemogram parameters are comparable with other antiepileptics. This study aimed to compare the effects of levetiracetam monotherapy for at least 6 months on hemogram indices with valproic acid.Methods:Cases aged 6-
Turgay Çokyaman, Tolga Kasap
doaj   +1 more source

Longitudinal Intra- and Inter-individual variation in T-cell subsets of HIV-infected and uninfected men participating in the LA Multi-Center AIDS Cohort Study. [PDF]

, 2019
To assess the intra-individual and inter-individuals biological variation and the effect of aging on lymphocyte T-cells subsets.We assessed lymphocyte phenotypes (CD3, CD4, and CD8 T-cells) in 89 HIV-1-infected and 88 uninfected white non-Hispanic men ...
Aziz, Najib, Chow, Marianne, Detels, Roger, Jamieson, Beth D, Martinez-Maza, Otoniel, Quint, Joshua J   +5 more
core  

Risk factors for wound infection in surgery for spinal metastasis [PDF]

, 2015
Wound infection rates are generally higher in patients undergoing surgery for spinal metastasis. Risk factors of wound infection in these patients are poorly understood.
A Grzegorzewska, AF Pull ter Gunne, D. van Popta, H Majeed, H Pascal-Moussellard, I McPhee, I. Siddique, IA Omeis, J Wise, J. Stephenson, KA Greene, N Sarhill, R. R. Verma, R. Rodrigues-Pinto, S Boriani, S Demura, S Dickhaut, S. Kumar, S. Mohammad   +18 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Prediction-based classification for longitudinal biomarkers

, 2010
Assessment of circulating CD4 count change over time in HIV-infected subjects on antiretroviral therapy (ART) is a central component of disease monitoring.
Azzoni, Livio, Foulkes, Andrea S., Johnson, Margaret A., Li, Xiaohong, Montaner, Luis J., Mounzer, Karam, Smith, Colette   +6 more
core   +1 more source

Immunological Changes after Cancer Treatment and Participation in an Exercise Program [PDF]

, 2003
Purpose: The purpose of this investigation was to evaluate the impact of undertaking peripheral blood stem cell transplantation (PBST) on T-cell number and function, and to determine the role of a mixed type, moderate intensity exercise program in ...
Andrykowski, Birk, Brenner, Brittenden, Chess, Cohen, Dimeo, Hannet, Henon, Keast, Laperriere, Laperriere, Molrine, Mosmann, Nieman, Nordon, Peters, Pyne, Rigsby, Shephard, Shevde, Spitzer, Talmadge, Uh, Weidemann, Winningham, Woods, Young-Moo   +27 more
core   +2 more sources