Results 21 to 30 of about 112,464 (281)

Emerging Role of EGFR Mutations in Creating an Immune Suppressive Tumour Microenvironment

Biomedicines, 2021
Several types of tumours overexpress the Epidermal Growth Factor Receptor (EGFR) in either wild type or mutated form. These tumours are often highly aggressive and difficult to treat.
Simran S. Kapoor, Dietmar M. W. Zaiss
doaj   +1 more source

A Decade of Experience With Alemtuzumab Therapy for Severe or Glucocorticoid-Resistant Kidney Transplant Rejection

Transplant International, 2023
Alemtuzumab is used as lymphocyte-depleting therapy for severe or glucocorticoid-resistant kidney transplant rejection. However, the long-term efficacy and toxicity of alemtuzumab therapy are unclear.
Lukas K. van Vugt, Lukas K. van Vugt, Marieke van der Zwan, Marian C. Clahsen-van Groningen, Marian C. Clahsen-van Groningen, Madelon van Agteren, Madelon van Agteren, Daphne M. Hullegie-Peelen, Daphne M. Hullegie-Peelen, Brenda C. M. De Winter, Brenda C. M. De Winter, Marlies E. J. Reinders, Marlies E. J. Reinders, Pedro Miranda Afonso, Pedro Miranda Afonso, Dennis A. Hesselink, Dennis A. Hesselink   +16 more
doaj   +1 more source

Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer. [PDF]

Breast Cancer Res, 2016
Background: Approximately 30 % of breast cancer patients receive chemotherapy, yet little is known about influences of current regimens on circulating lymphocyte levels and phenotypes. Similarly, clinico-pathological factors that modify these influences,
Verma R, Foster RE, Horgan K, Mounsey K, Nixon H, Smalle N, Hughes TA, Carter CR.   +7 more
europepmc   +2 more sources

Prognostic value of peripheral blood lymphocyte subsets in patients with solid cancers: a retrospective study [PDF]

Archives of the Balkan Medical Union, 2021
Introduction. Lymphocyte subsets are important in regulating immunity and specific killing of tumour cells and appear to be strongly associated with the development of solid tumours.
Marieta-Elena PANAIT, Antonela BUSCA, Ana-Maria COMAN, Mariana SAULEA, Lucica-Madalina BOLOVAN   +4 more
doaj   +1 more source

Understanding the slow depletion of memory CD4(+) T cells in HIV infection [PDF]

, 2007
Background The asymptomatic phase of HIV infection is characterised by a slow decline of peripheral blood CD4(+) T cells. Why this decline is slow is not understood.
Nigel Klein, Klein Nigel, Antia, Rustom, Yates, Andrew, Callard, Robin, Antia Rustom, Yates, A, Callard, R, Klein, Nigel, Jaroslav Stark, Stark, J, Andrew Yates, Stark Jaroslav, Rustom Antia, Callard Robin, Stark, Jaroslav, Yates Andrew, Robin Callard, Klein, N, Antia, R   +19 more
core   +1 more source

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Pavic, Ivica, Rukavina, Danijel, Koszinowski, Ulrich H., Koszinowski, U H, Lucin, Pero, Rukavina, Daniel, Jonjic, Stipan   +6 more
core   +1 more source

Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy

Haematologica, 2012
Background Donor lymphocyte infusions can induce remissions in patients with relapse after allogeneic hematopoietic stem cell transplantation. Nevertheless, some grafted patients never display any signs of alloreactivity, either following allogeneic ...
Soumia Touil, Michelle Rosenzwajg, Dan Avi Landau, Philippe Le Corvoisier, Charlotte Frédéric, David Klatzmann, Sébastien Maury, José L. Cohen   +7 more
doaj   +1 more source

Effect of biological agents on B-lymphocyte subpopulations in patients with systemic lupus erythematosus

Современная ревматология, 2019
Objective: to evaluate the effect of different biological agents (BAs), including rituximab (RTM) and belimumab (BLM) combination therapy, on B-lymphocyte subpopulations during a follow-up of patients with systemic lupus erythematosus (SLE).Patients and ...
A. A. Mesnyankina, S. K. Solovyev, E. A. Aseeva, A. P. Aleksankin, E. N. Aleksandrova, E. L. Nasonov   +5 more
doaj   +1 more source

Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting [PDF]

, 2007
Background: An elevated preoperative white blood cell count has been associated with a worse outcome after coronary artery bypass grafting (CABG). Leukocyte subtypes, and particularly the neutrophil-lymphocyte (N/L) ratio, may however, convey superior ...
Small, Gary R., Gibson, George, Jeffrey, Robert R., Croal, Bernard L., Gibson, Patrick H., Cuthbertson, Brian, El-Shafei, Hussein, Hillis, Graham S., Ifezulike, Ada I., Buchan, Keith G.   +9 more
core   +1 more source

Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection. [PDF]

PLoS Pathog, 2019
Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly correlative with fatalities. However, the mechanisms leading to T-cell depletion remain largely unknown.
Younan P, Santos RI, Ramanathan P, Iampietro M, Nishida A, Dutta M, Ammosova T, Meyer M, Katze MG, Popov VL, Nekhai S, Bukreyev A.   +11 more
europepmc   +2 more sources