Results 61 to 70 of about 127,310 (303)

How and why systemic inflammation worsens quality of life in patients with advanced cancer [PDF]

, 2017
Introduction: The presence of an innate host systemic inflammatory response has been reported to be a negative prognostic factor in a wide group of solid tumour types in both the operable and advanced setting, both local and distant.
Dolan, Ross D., Horgan, Paul G., McMillan, Donald C., McSorley, Stephen T., Roxburgh, Campbell S.D.   +4 more
core   +1 more source

Correlation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and carcinoembrionic antigen level in colorectal cancer [PDF]

Jurnal Kedokteran dan Kesehatan Indonesia, 2018
Background: Colorectal cancer is one of cancer that has a high mortality rate. Cancer is associated with a systemic inflammatory response. Carcinoembryonic antigen (CEA) is a colorectal cancer prognostic marker, but this examination is quite expensive and not always ubiquitously available.
Candrawati, Oktania, Utomo, Bambang Eko Broto Hari, Sofii, lmam   +2 more
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Immune compromise in HIV-1/HTLV-1 coinfection with paradoxical resolution of CD4 lymphocytosis during antiretroviral therapy: a case report [PDF]

, 2015
Human immunodeficiency virus type-1 (HIV-1) and human T lymphotropic virus type-1 (HTLV-1) infections have complex effects on adaptive immunity, with specific tropism for, but contrasting effects on, CD4 T lymphocytes: depletion with HIV-1, proliferation
Bangham, C, Basnayake, S, Cook, L, Kagdi, H, Pozniak, A, Rockwood, N, Taylor, GP   +6 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Nutrition, diet and immunosenescence [PDF]

, 2013
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
Agrawal, Agrawal, Akbar, Almanzar, Alonso, Alperovich, Alvarez-Rodriguez, Arunachalam, Azzini, Bates, Bechoua, Belisle, Belisle, Berzins, Blomberg, Bogden, Borrego, Bouwens, Bravo, Buffa, Bunout, Butcher, Calder, Camous, Canaday, Cannizzo, Carluccio, Castle, Cevenini, Chandra, Chatta, Chidrawar, Chung, Ciaramella, Clambey, Clark, Claudio Nicoletti, Colonna-Romano, Corridan, Corsini, Cortes, Cossack, Currier, De La Fuente, De la Fuente, De la Fuente, De Martinis, DelaRosa, DelaRosa, Della Bella, Dell’Agli, Dewan, Di Lorenzo, Dong, Donnini, Dorshkind, Dubey, Duchateau, Dunn-Walters, Effros, Enos, Estruch, Farges, Fateh, Faunce, Fearnley, Feart, Fietta, Flores, Fortes, Fortin, Fortin, Franceschi, Franceschi, Frasca, Frasca, Fulop, Fulop, Fulop, Fulop, Galli, Gao, Gayoso, Gebremichael, Gibson, Gibson, Gill, Gill, Ginaldi, Gomez, Goronzy, Goronzy, Guigoz, Guigoz, Hadziabdic, Hakim, Hamilton-Miller, Haynes, Haynes, Haynes, Herndler-Brandstetter, Herrero, Herrero, Hilmer, Hodkinson, Hong, Ishimoto, Jing, Kahmann, Kamal Ivory, Khan, Kowdley, Larbi, Larbi, Lasheras, Le Garff-Tavernier, Lee, Lesourd, Lesourd, Ligthart, Lung, Magrone, Mariani, Mariani, Martinez-Gonzalez, Maue, McElhaney, Merchant, Meydani, Meydani, Meydani, Meydani, Mitchell, Monagas, Murasko, Mysliwska, Mònica Maijó, Nagel, Nicoletti, Nicoletti, Nikolich-Zugich, Nova, Nova, Ogawa, Ogawa, Osler, Ouwehand, Ouwehand, Pae, Paganelli, Pallast, Pawelec, Peralbo, Peralbo, Pfister, Plackett, Plowden, Prakash, Prasad, Prasad, Prasad, Prasad, Psaltopoulou, Pérez-Cabezas, Rees, Rink, Salas-Salvado, Sarah J. Clements, Saule, Saurwein-Teissl, Scarmeas, Scarmeas, Schenkein, Schiffrin, Schiffrin, Schwaiger, Shaw, Shodell, Simon R. Carding, Sofi, Sofi, Solana, Solana, Solana, Sridharan, Steger, Stout-Delgado, Swift, Tangney, Tasat, Tortorella, Tortorella, Trichopoulou, Uyemura, Valls-Pedret, van Duin, Varas, Vasto, Vasto, Vetvicka, Vulevic, Waitzberg, Wallace, Watson, Webster, Weiskopf, Weksler, Wenisch, Wikby, Willett, Wong, Wordsworth, Wu, Yaqoob, Yaqoob, Yuan, Zanni, Zissel   +217 more
core   +1 more source

Evaluation of Neutrophil to Lymphocyte Ratio and Monocyte to Lymphocyte Ratio in Gouty Arthritis Attacks [PDF]

West Indian Medical Journal, 2015
Abstract To evaluate neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) in patients with gouty arthritis. Forty-five patients with gout and 45 healthy age and gender matched individuals, were included in this study. Clinical and laboratory data of patients during acute gouty arthritis (AGA) attack period, as well as in ...
A Şahin, AU Uslu, D Seven, A Camci, Ö Demirpençe, M Şahin, T Uncu, B Aydın   +7 more
openaire   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

DENDRITIC CELL DIFFERENTIATION BLOCKED BY PRIMARY EFFUSION LYMPHOMA-RELEASED FACTORS IS PARTIALLY RESTORED BY INHIBITION OF P38 MAPK [PDF]

, 2010
To better understand the molecular mechanisms underlying the dendritic cell (DC) defects in cancer, we analyzed which signaling pathway is implicated in the abnormal monocyte differentiation into DC determined by the presence of Primary effusion lymphoma
CIRONE, Mara, DI RENZO, Livia Maria, FAGGIONI, Alberto, FRATI, Luigi, G. Borgia, G. Lucania, TRIVEDI, PANKAJ   +6 more
core   +2 more sources

Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen, Wenting Huang, Yitian Liu, Xuan Chen, Buyu Ke, Qian Shen, Hanyu Cai, Jing Sun, Yan Li, Yungang Cao, Beilei Hu, Keyang Chen   +11 more
wiley   +1 more source