Results 121 to 130 of about 311,006 (351)

A Weakly Supervised Segmentation Network Embedding Cross-scale Attention Guidance and Noise-sensitive Constraint for Detecting Tertiary Lymphoid Structures of Pancreatic Tumors [PDF]

arXiv, 2023
The presence of tertiary lymphoid structures (TLSs) on pancreatic pathological images is an important prognostic indicator of pancreatic tumors. Therefore, TLSs detection on pancreatic pathological images plays a crucial role in diagnosis and treatment for patients with pancreatic tumors.
arxiv  

Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial.

Annals of Oncology, 2014
BACKGROUND We have previously shown the prognostic importance of tumor-infiltrating lymphocytes (TILs) in newly diagnosed triple-negative breast cancer (TNBC) using tumor samples from a large clinical trial cohort.
S. Loi, S. Loi, S. Michiels, S. Michiels, R. Salgado, N. Sirtaine, V. Jose, D. Fumagalli, P. Kellokumpu-Lehtinen, P. Bono, V. Kataja, C. Desmedt, M. Piccart, S. Loibl, C. Denkert, M. Smyth, H. Joensuu, C. Sotiriou   +17 more
semanticscholar   +1 more source

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. [PDF]

, 2014
BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood.
Amling, Christopher L, Carroll, Peter, Chan, Stephen, Corman, John, Fong, Lawrence, Frohlich, Mark W, Lewis, Jera, Sheikh, Nadeem A, Simko, Jeffrey, Sims, Robert B, Small, Eric J, Stephenson, Robert A, Weinberg, Vivian   +12 more
core   +2 more sources

Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma.

PLoS ONE, 2020
BACKGROUND:Tumor-infiltrating lymphocytes include tumor-reactive lymphocytes and regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear.
Kazushige Koike, Hironari Dehari, Kazuhiro Ogi, Shota Shimizu, Koyo Nishiyama, Tomoko Sonoda, Takanori Sasaki, Takashi Sasaya, Kei Tsuchihashi, Tadashi Hasegawa, Toshihiko Torigoe, Hiroyoshi Hiratsuka, Akihiro Miyazaki   +12 more
doaj   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Prognostic value of tumor-infiltrating lymphocytes in melanoma: a systematic review and meta-analysis

Oncoimmunology, 2019
Tumor-infiltrating lymphocytes (TILs) are associated with prognosis in various tumors. However, it remains controversial whether the presence of TILs is related to an improved prognosis in melanoma.
Q. Fu, N. Chen, Chunlei Ge, Ruilei Li, Zhen Li, Baozhen Zeng, Chunyan Li, Ying Wang, Yuanbo Xue, Xin Song, Heng Li, Gaofeng Li   +11 more
semanticscholar   +1 more source

T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation [PDF]

, 1992
Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading to tissue damage ...
Eisenburg, Josef, Hoffmann, Robert M., Jung, Maria C., Messer, Gerald, Möller, Achim, Paumgartner, Gustav, Riethmüller, Gert, Spengler, Ulrich, Weiss, Elisabeth H., Zachoval, Reinhard   +9 more
core   +1 more source

CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

OncoImmunology, 2017
CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognate antigen. We observed intense expression of CD69 on tumor-infiltrating T-lymphocytes that reside in the hypoxic tumor microenvironment and hypothesized ...
Sara Labiano, Florinda Meléndez-Rodríguez, Asís Palazón, Álvaro Teijeira, Saray Garasa, Iñaki Etxeberria, M. Ángela Aznar, Alfonso R. Sánchez-Paulete, Arantza Azpilikueta, Elixabet Bolaños, Carmen Molina, Hortensia de la Fuente, Patricia Maiso, Francisco Sánchez-Madrid, Manuel Ortiz de Landázuri, Julián Aragonés, Ignacio Melero   +16 more
doaj   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Association and prognostic significance of BRCA1/2-mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer

OncoTarget, 2016
Immune checkpoint inhibitors (e.g., anti-PD-1 and anti-PD-L1 antibodies) have demonstrated remarkable efficacy against hypermutated cancers such as melanomas and lung carcinomas.
K. Strickland, B. Howitt, S. Shukla, S. Rodig, Lauren L. Ritterhouse, Joyce F. Liu, J. Garber, Dipanjan Chowdhury, Catherine J. Wu, A. D’Andrea, U. Matulonis, P. Konstantinopoulos   +11 more
semanticscholar   +1 more source