Results 141 to 150 of about 311,006 (351)
Understanding and Modelling the Complexity of the Immune System: Systems Biology for Integration and Dynamical Reconstruction of Lymphocyte Multi-Scale Dynamics [PDF]
Virtual Physiological Human Conference 2014, Sep 2014, Trondheim,
Norway, 2020 Understanding and modelling the complexity of the immune system is a challenge that is shared by the ImmunoComplexiT$^1$ thematic network from the RNSC. The immune system is a complex biological, adaptive, highly diversified, self-organized and degenerative cognitive network of entities, allowing for a robust and resilient system with emergent ...
arxiv
Journal of Immunotherapy for Cancer, 2019 BackgroundType I interferons (IFN-I) have recently emerged as key regulators of tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T lymphocytes (CTLs) in the tumor microenvironment is largely unknown.MethodsTumor ...
Chunwan Lu +7 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
High CTLA-4 expression correlates with poor prognosis in thymoma patients [PDF]
, 2018 Thymomas, tumors that arise from epithelial cells of the thymus gland, are the most common neoplasms of the anterior mediastinum, with an incidence rate of approximately 2.5 per million/year.
Amantini, Consuelo +13 more
core +1 more source
A Dynamical Systems Perspective on Chimeric Antigen Receptor T-Cell Dosing [PDF]
, 2018 Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. In this perspective paper a mathematical basis for personalized dosing of CAR T cells is introduced.
arxiv +1 more source
Clinical Cancer Research, 2019 Purpose: Because durable response to programmed cell death 1 (PD-1) inhibition is limited to a subset of melanoma patients, new predictive biomarkers could have clinical utility.
Pok Fai Wong +8 more
semanticscholar +1 more source
Tumor-infiltrating lymphocytes (TILs) from patients with glioma
OncoImmunology, 2017 Tumor-infiltrating lymphocytes (TILs) may represent a viable source of T cells for the biological treatment of patients with gliomas. Glioma tissue was obtained from 16 patients, tumor cell lines were established, and TILs were expanded in 16/16 cases ...
Zhenjiang Liu +13 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.NeoCast is a next‐generation, solvent‐free, non‐adhesive liquid embolic designed for indications where deep occlusion is desired (e.g., tumors and chronic subdural hematoma). This novel agent offers ideal embolic properties: injectability, controllability, excellent visibility, and biocompatibility.
Quynh P. Pham +16 more
wiley +1 more source
Cancer Detection via Determination of Fractal Cell Dimension [PDF]
arXiv, 1995 We utilize the fractal dimension of the perimeter surface of cell sections as a new observable to characterize cells of different types. We propose that it is possible to distinguish cancerous from healthy cells with the aid of this new approach. As a first application we show that it is possible to perform this distinction between patients with hairy ...
arxiv
Scientific Reports, 2019 Due to the loss of DNA repair mechanisms in colorectal cancer (CRC) with microsatellite instability (MSI), somatic mutations accumulate within DNA; making them more prone to attack by tumor infiltrating lymphocytes (TIL) and macrophages.
Sumana Narayanan +6 more
semanticscholar +1 more source