Results 11 to 20 of about 1,496,674 (257)

Tumor infiltrating lymphocytes in ovarian cancer. [PDF]

Asian Pacific Journal of Cancer Prevention, 2015
Several improvements in ovarian cancer treatment have been achieved in recent years, both in surgery and in combination chemotherapy with targeting. However, ovarian tumors remain the women's cancers with highest mortality rates.
Perniola, Giorgia, Panici, Pierluigi Benedetti, Palaia, Innocenza, Papadia, Andrea, BENEDETTI PANICI, PIERLUIGI, Papadia, A, Di Donato, Violante, Attar, R, Gasparri, Maria Luisa, GASPARRI, MARIALUISA, Farooqi, Ammad Ahmad, Attar, Rukset, Marchetti, C, Marchetti, Claudia, Farooqi, Aa   +14 more
core   +9 more sources

Advances in tumor-infiltrating B lymphocytes

Central European Journal of Immunology
In the landscape of tumor immunotherapy, T cell-mediated immune responses have consistently captured the attention, while the contributions of B cells have been neglected.
Jinxiu Chen, Yule Zhang, Hongyan Wu, Ming Huang, Chunyu Cao   +4 more
core   +4 more sources

Tumor-Infiltrating Lymphocytes in Melanoma [PDF]

Current Oncology Reports, 2012
Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) is arguably the most effective treatment for patients with metastatic melanoma. With higher response rates than ipilimumab or IL-2, and longer durations of response than vemurafenib, TIL therapy carries the potential to transform current outcomes in melanoma, while also defining the way ...
Sylvia, Lee, Kim, Margolin
openaire   +2 more sources

Tumor-infiltrating lymphocytes in the immunotherapy era [PDF]

Cellular & Molecular Immunology, 2020
The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune checkpoint inhibitor therapy in cancer patients has been linked to the quality and magnitude of T cell, NK cell, and more recently, B cell responses within the tumor microenvironment.
Sterre T, Paijens, Annegé, Vledder, Marco, de Bruyn, Hans W, Nijman   +3 more
openaire   +2 more sources

The role of tumor-infiltrating lymphocytes in cholangiocarcinoma

Journal of Experimental & Clinical Cancer Research, 2022
AbstractCholangiocarcinoma (CCA) is the second most common primary liver cancer and associated with a dismal prognosis due to the lack of an efficient systemic therapy. In contrast to other cancers, new immunotherapies have demonstrated unsatisfactory results in clinical trials, underlining the importance of a deeper understanding of the special tumor ...
Dong Liu, Lara Rosaline Heij, Zoltan Czigany, Edgar Dahl, Sven Arke Lang, Tom Florian Ulmer, Tom Luedde, Ulf Peter Neumann, Jan Bednarsch   +8 more
openaire   +5 more sources

Tumor-Infiltrating Lymphocytes in Wilms Tumor [PDF]

Indian Journal of Medical and Paediatric Oncology, 2020
Abstract Purpose: T-lymphocytes-infiltrating tumors (TILs) are white blood cells (CD3+) found within the tumor and are thought to indicate a T-cell-mediated specific immune response. The purpose was to evaluate the presence and the subtypes of TILs in Wilms tumor (WT) specimens.
Devendra Kumar Yadav, Vishesh Jain, Amit Kumar Dinda, Sandeep Agarwala   +3 more
openaire   +2 more sources

Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]

, 2013
Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
Kim, Mia, Lazariotou, Maria, Gasser, Martin, Waaga, Ana Maria da Silva Rosa, Martin Gasser, Grimmig, Tanja, Heemann, Uwe, Blaheta, Roman A., Andreas Rosenwald, Igor Tsaur, Meier, Eva, Rosenwald, Andreas, Christoph-Thomas Germer, Martin Grimm, Waaga-Gasser, Ana Maria, Mia Kim, Uwe Heemann, Eva Meier, Roman Blaheta, Ana Maria Waaga-Gasser, Germer, Christoph-Thomas, Tsaur, Igor, Blaheta, Roman, Tanja Grimmig, Grimm, Martin, Maria Lazariotou, Kim, M;Grimmig, T;Grimm, M;Lazariotou, M;Meier, E;Rosenwald, A;Tsaur, I;Blaheta, R;Heemann, U;Germer, CT;Waaga-Gasser, AM;Gasser, M, Heemann Uwe, Gasser Martin, Blaheta Roman, Germer Christoph-Thomas, Grimmig Tanja, Lazariotou Maria, Kim Mia, Rosenwald Andreas, Grimm Martin, Meier Eva, Tsaur Igor, Waaga-Gasser Ana Maria   +38 more
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T lymphocytes from patients with primary biliary cirrhosis produce reduced amounts of lymphotoxin, tumor necrosis factor and interferon-gamma upon mitogen stimulation [PDF]

, 1992
Primary biliary cirrhosis (PBC) is considered an autoimmune disease characterized by destruction of small intrahepatic bile ducts by lymphocytes. Altered functions of these lymphocytes might reflect an abnormal immune response leading to tissue damage ...
Eisenburg, Josef, Spengler, Ulrich, Hoffmann, Robert M., Paumgartner, Gustav, Jung, Maria C., Messer, Gerald, Möller, Achim, Weiss, Elisabeth H., Zachoval, Reinhard, Riethmüller, Gert   +9 more
core   +1 more source

Role of tumor architecture in elicitation of effector functions of human cytotoxic T-lymphocytes recognizing melanoma associated antigens [PDF]

, 2006
Growth in 3D architectures has been shown to promote the resistance of cancers to treatment with drugs, cytokines, or irradiation, thereby potentially playing an important role in tumor expansion.
Ghosh, Sourabh
core   +1 more source

The biologic importance of tumor‐infiltrating lymphocytes [PDF]

Journal of Cutaneous Pathology, 2010
Detailed pathologic analysis has delineated a close association between intratumoral CD 8+ cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the presence at tumor sites of negative immune regulatory elements, such as FoxP 3+ T cells (Tregs) and PD‐1/PD‐L1 co‐stimulatory molecules, is closely associated with inferior ...
F Stephen, Hodi, Glenn, Dranoff
openaire   +2 more sources