Results 211 to 220 of about 1,496,674 (257)
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Tumor-Infiltrating Lymphocytes
The Cancer Journal, 2015Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs) in combination with lymphodepletion and high-dose interleukin 2 has shown reproducible objective response rates of approximately 50% in patients with highly advanced, refractory metastatic melanoma.
Michal J, Besser +2 more
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Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images [PDF]
Cell Reports, 2018 Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA
José Sebastião dos Santos +2 more
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Cancer Cytopathology, 2022
BackgroundTumor‐infiltrating lymphocytes (TILs) are associated with various clinicopathological features. Using cytologic specimens for assessing TILs remains to be established. This retrospective study aimed to establish a practical method to assess TILs in cytologic samples.MethodsThe authors found 1101 breast fine‐needle aspiration biopsy (FNAB ...
Toru Odate +5 more
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BackgroundTumor‐infiltrating lymphocytes (TILs) are associated with various clinicopathological features. Using cytologic specimens for assessing TILs remains to be established. This retrospective study aimed to establish a practical method to assess TILs in cytologic samples.MethodsThe authors found 1101 breast fine‐needle aspiration biopsy (FNAB ...
Toru Odate +5 more
openaire +2 more sources
Clonal dynamics of tumor-infiltrating lymphocytes
European Journal of Immunology, 2005The presence of tumor-infiltrating lymphocytes (TIL) provides important evidence of anti-tumor immunity in vivo. However, TIL are usually not sufficient for inhibiting tumor growth. We explored the spatial and temporal aspects of clonal accumulation of TIL using RT-PCR/single-strand conformation polymorphism analysis.
Rong, Yu +4 more
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Tumor-infiltrating lymphocytes: A new hope
Cancer CellTumor-infiltrating lymphocytes (TILs) can be massively expanded from resected tumors and used as a cellular treatment for advanced malignancies. TILs require a preparative non-myeloablative chemotherapy followed by an abbreviated course of interleukin-2.
Amod A, Sarnaik +3 more
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Tumor-Infiltrating Lymphocyte Therapy and Neoantigens
The Cancer Journal, 2017The adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes has been shown to be effective at mediating tumor regression in more than half of patients with metastatic melanoma and in mediating long-term complete regression in approximately one fourth of all patients with this cancer.
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Reporting Tumor Infiltrating Lymphocytes
2012The presence of many tumor infiltrating lymphocytes (TILs) in primary cutaneous melanoma is associated with a better prognosis. The degree of lymphocytic interaction with the tumor cells is graded as “brisk”, “non-brisk” or “absent” as defined below:
Kasia Szyfelbein Masterpol +2 more
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Tumor-Infiltrating Lymphocyte Therapy
The Cancer Journal, 2015Autologous adoptive T-cell therapies have made tremendous strides over the last few years with excitement currently being generated by technologies that can reprogram T-cell specificities toward any desired antigen including chimeric antigen receptors and recombinant T-cell receptors.
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TUMOR INFILTRATING LYMPHOCYTES*
Annals of the New York Academy of Sciences, 1976E, Klein +4 more
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A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
Cell, 2021Peng Du, Jia-Fu Ji, Jia Wang
exaly