Results 201 to 210 of about 115,860 (261)

An Avalanche Effect Nanomodulator Triggers Cascade Ferroptosis/Cuproptosis for Immunosuppressive Microenvironment Remodeling

Advanced Science, EarlyView.
A nanomodulator called L‐Arginine/lificiguat@Copper‐hollow Prussian blue@Calcium phosphate nanoparticles is constructed to launch a self‐amplifying “avalanche effect” in tumor cells. The ensuing cascade, triggered by the acidic tumor microenvironment and near‐infrared light, induces calcium overload, generates a reactive oxygen species and reactive ...
Hongmei Zhou, Caixi Yu, Guilan Xu, Lijuan Liu, Yujia Liang, Yulin Liang, He Ding, Litu Zhang, Piaoping Yang, Chen Wang   +9 more
wiley   +1 more source

Associations between tumor immune response and prognosis in node-negative breast cancer patients in the randomized DBCG HYPO trial. [PDF]

BMC Cancer
Özcan D, Nielsen PS, Alsner J, Nielsen MH, Maae E, Milo MLH, Overgaard J, Offersen BV, Tramm T.   +8 more
europepmc   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Translational control shapes the suppressive output of tumour-infiltrating regulatory T cells by coupling metabolism to protein synthesis

OLIVETO S, FERRARI I, GRUARIN P, CORDIGLIERI C, Miluzio A, CURTI S, Manfrini N, Pesce E, MATTINZOLI D, IKEATA M, NOVELLIS P, VERONESI G, PRATI D, BENVENUTI M, PAGANI M, MUTTI L, CASTELLANO G, Abrignani S, Biffo S.   +18 more
europepmc   +1 more source

The immune landscape of melanoma microenvironmental crosstalk. [PDF]

Front Immunol
Yang Q, Yang Q, Xu B, Chen X, Zheng H, Wang M, Zhang W, Wu J, Cheng H.   +8 more
europepmc   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Concordance and Prognostic Impact of Tumor-Stroma Ratio and Tumor-Infiltrating Lymphocytes in Preoperative Biopsies and Matched Surgical Specimens in Oral Squamous Cell Carcinoma. [PDF]

Diagnostics (Basel)
Mozola M, Herman M, Brachtlova K, Michalek J, Zapletalova J, Bednarik Z, Hendrych M, Pink R, Tvrdy P, Hermanova M.   +9 more
europepmc   +1 more source

Multi‐Omics Integration Identifies a CDH3‐Associated Malignant Epithelial State and Immunosuppressive Niche to Predict Prognosis in Thymic Epithelial Tumors

Advanced Science, EarlyView.
Single‐cell, spatial, molecular, and pathology analyses identify a CDH3‐associated malignant epithelial state in thymic epithelial tumors. This state links stem‐like and EMT programs to M2 macrophage–rich immunosuppressive niches, genomic instability, poor survival, and drug vulnerability.
Yuntao Feng, Jingyu Chen, Lang Xia, Tao Wang, Yuzhou Wang, Lei Zhang, Guofang Zhao, Long Xu, Juemin Yu, Yunlang She, Junqi Wu, Yue Zhao, Chang Chen, Deping Zhao   +13 more
wiley   +1 more source

High SOX17 expression is correlated with favorable prognosis and CD8(+) TILs expression in patients with pancreatic cancer after curative resection. [PDF]

Transl Oncol
Yu J, Pan Y, Chen Y, Shu Z, Ma L, Wu B, Li J, Li J, Lan C.   +8 more
europepmc   +1 more source

Error in Tables 2 and 3.

JAMA Oncol
europepmc   +1 more source