Results 51 to 60 of about 168,260 (202)
Increased NY-ESO-1 Expression and Reduced Infiltrating CD3+ T Cells in Cutaneous Melanoma
Journal of Immunology Research, 2015 NY-ESO-1 is a cancer-testis antigen aberrantly expressed in melanomas, which may serve as a robust and specific target in immunotherapy. NY-ESO-1 antigen expression, tumor features, and the immune profile of tumor infiltrating lymphocytes were assessed ...
Mara Giavina-Bianchi +6 more
doaj +1 more source
Splenectomy is associated with an aggressive tumor growth pattern and altered host immunity in an orthotopic syngeneic murine pancreatic cancer model. [PDF]
, 2017 The purpose of this study was to investigate whether splenectomy influences the tumor growth and metastatic pattern in an orthotopic syngeneic murine pancreatic cancer model.
Bouvet, Michael +7 more
core +1 more source
Digital Genomic Quantification of Tumor-Infiltrating Lymphocytes [PDF]
Science Translational Medicine, 2013 A digital DNA-based assay demonstrates an association between higher TIL counts and improved survival among women with ovarian cancer.
Harlan S, Robins +6 more
openaire +2 more sources
Middle East Journal of Cancer, 2017 Background: Melanoma is one of the most immunogenic tumors that causes a significant immune response. Tumor infiltrating lymphocytes are an important part of this response. Tumor infiltrating lymphocytes are lymphocytes in close association with tumor
Alireza Ghanadan +3 more
doaj
Generating CAR T cells from tumor-infiltrating lymphocytes
Therapeutic Advances in Vaccines and Immunotherapy, 2021 Background: Tumor-infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T-cell therapies have demonstrated promising, though limited, efficacy against melanoma.
Jane K. Mills +8 more
doaj +1 more source
Immunology of Tumor Infiltrating Lymphocytes
Annals of Surgery, 1985 Frequently peripheral blood lymphocytes (PBL) do not reflect the tumor host relationship and cell mediated immunity in the PBL does not often correlate with prognosis. The tumor infiltrating lymphocytes (TIL) interact most closely with the tumor cells and are likely to more accurately reflect tumor host interactions.
openaire +3 more sources
The biologic importance of tumor‐infiltrating lymphocytes [PDF]
Journal of Cutaneous Pathology, 2010 Detailed pathologic analysis has delineated a close association between intratumoral CD 8+ cytotoxic T cells and favorable clinical outcomes in diverse cancers. Conversely, the presence at tumor sites of negative immune regulatory elements, such as FoxP 3+ T cells (Tregs) and PD‐1/PD‐L1 co‐stimulatory molecules, is closely associated with inferior ...
F Stephen, Hodi, Glenn, Dranoff
openaire +2 more sources
Tumor-Infiltrating Lymphocytes—Location for Prognostic Evaluation [PDF]
Clinical Cancer Research, 2019 Abstract Tumor-infiltrating lymphocytes (TIL) are crucial for the success of immunotherapy, and their density can predict prognosis. It has now been shown that computer-based analysis of the spatial organization of TILs adds prognostic value in early-stage non–small cell lung cancer, possibly improving the treatment algorithm to prevent ...
Michael, Peled, Amir, Onn, Roy S, Herbst
openaire +2 more sources
Association of tumor deposits with tumor-infiltrating lymphocytes and prognosis in gastric cancer
World Journal of Surgical Oncology, 2022 Background To investigate the relationship between tumor deposits (TDs) with the clinicopathological characteristics tumor-infiltrating lymphocytes (TILs) and prognosis of gastric cancer.
Xinyue Li, Jing Yang
doaj +1 more source
Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. [PDF]
, 2019 Glioblastoma is the most common primary malignant brain tumor in adults and is associated with poor survival. The Ivy Foundation Early Phase Clinical Trials Consortium conducted a randomized, multi-institution clinical trial to evaluate immune responses ...
Arrillaga-Romany, Isabel C +29 more
core