Results 51 to 60 of about 311,006 (351)

Higher Numbers of T-Bet+ Tumor-Infiltrating Lymphocytes Associate with Better Survival in Human Epithelial Ovarian Cancer

Cellular Physiology and Biochemistry, 2017
Background/Aims: T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human ...
Yun Xu, Lujun Chen, Bin Xu, Yuqi Xiong, Min Yang, Xiaohui Rui, Liangrong Shi, Changping Wu, Jingting Jiang, Binfeng Lu   +9 more
doaj   +1 more source

A thermodynamical perspective of immune capabilities [PDF]

Journal of Theoretical Biology 287 (2011) 48-63, 2011
We consider the mutual interactions, via cytokine exchanges, among helper lymphocytes, B lymphocytes and killer lymphocytes, and we model them as a unique system by means of a tripartite network. Each part includes all the different clones of the same lymphatic subpopulation, whose couplings to the others are either excitatory or inhibitory (mirroring ...
arxiv   +1 more source

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group

npj Breast Cancer, 2020
Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors.
M. Amgad, E. Stovgaard, E. Balslev, J. Thagaard, Weijie Chen, S. Dudgeon, Ashish Sharma, J. Kerner, C. Denkert, Yinyin Yuan, K. AbdulJabbar, S. Wienert, P. Savas, L. Voorwerk, Andrew H. Beck, A. Madabhushi, J. Hartman, Manu Sebastian, H. Horlings, J. Hudeček, F. Ciompi, D. Moore, Rajendra Singh, Elvire Roblin, M. Balancin, M. Mathieu, J. Lennerz, Pawan Kirtani, I. Chen, J. Braybrooke, G. Pruneri, S. Demaria, S. Adams, S. Schnitt, S. Lakhani, F. Rojo, L. Comerma, S. Badve, M. Khojasteh, W. Symmans, C. Sotiriou, Paula I. Gonzalez-Ericsson, K. Pogue-Geile, Rim S. Kim, D. Rimm, G. Viale, S. Hewitt, J. Bartlett, F. Penault-Llorca, S. Goel, H. Lien, S. Loibl, Z. Kos, S. Loi, M. Hanna, S. Michiels, M. Kok, T. Nielsen, A. Lazar, Z. Bago-Horvath, L. Kooreman, J. A. van der Laak, J. Saltz, B. Gallas, U. Kurkure, Michael Barnes, R. Salgado, L. Cooper, A. A. I. A. A. A. A. A. A. M. A. Hyytiäinen Hida Thompson Lefevre Gown Lo Sapino Mo, Aini Hyytiäinen, A. Hida, A. Thompson, A. Lefevre, A. Gown, Amy A. Lo, A. Sapino, Andre Moreira, A. Richardson, A. Vingiani, A. Bellizzi, A. Tutt, A. Guerrero-Zotano, A. Grigoriadis, A. Ehinger, A.C. Garrido-Castro, A. Vincent-Salomon, A. Laenkholm, A. Cimino-Mathews, A. Srinivasan, B. Ács, Baljit Singh, B. Calhoun, Benjamin Haibe-Kans, B. Solomon, B. Thapa, B. Nelson, C. Castañeda, Carmen Ballesteroes-Merino, C. Criscitiello, Carolien Boeckx, C. Colpaert, C. Quinn, C. Chennubhotla, C. Swanton, C. Solinas, C. Hiley, D. Drubay, D. Bethmann, D. Dillon, D. Larsimont, D. Sabanathan, D. Peeters, D. Zardavas, D. Höflmayer, Douglas B. Johnson, E. Thompson, E. Brogi, E. Perez, E. Elgabry, E. Blackley, Emily S. Reisenbichler, E. Bellolio, E. Chmielik, F. Gaire, F. André, F. Lu, Farid Azmoudeh-Ardalan, Forbius Tina Gruosso, F. Peale, F. Hirsch, Frederick Klaushen, Gabriela Acosta-Haab, G. Farshid, G. G. Van den Eynden, G. Curigliano, G. Floris, G. Broeckx, H. Koeppen, H. R. Haynes, H. McArthur, H. Joensuu, H. Olofsson, I. Cree, I. Nederlof, I. Frahm, I. Brčić, Jack Junjie Chan, Jacqueline A. Hall, James Ziai, J. Brock, J. Wesseling, J. Giltnane, J. Lemonnier, J. Zha, Joana M. Ribeiro, J. Carter, J. Hainfellner, J. L. Quesne, J. Juco, J. Reis-Filho, J. G. van den Berg, Joselyn Sanchez, J. Sparano, J. Cucherousset, J. Araya, J. Adam, J. Balko, K. Saeger, K. Siziopikou, K. Willard-Gallo, K. Sikorska, K. Weber, K. Steele, K. Emancipator, K. El Bairi, K. Blenman, K. Allison, K. K. van de Vijver, Konstanty Korski, L. Pusztai, L. Buisseret, Leming Shi, L. Shi-wei, L. Molinero, M. V. Estrada, M. van Seijen, M. Lacroix-Triki, M. Cheang, Maise Al Bakir, M. J. van de Vijver, M. Dieci, M. Rebelatto, M. Piccart, M. Goetz, M. Preusser, M. Sanders, M. Regan, M. Christie, M. Misialek, M. Ignatiadis, M. de Maaker, M. V. van Bockstal, Miluska Castillo, N. Harbeck, N. Tung, Nele Laudus, N. Sirtaine, N. Burchardi, N. Ternès, N. Radosevic-Robin, O. Gluz, O. Grimm, P. Nuciforo, P. Jank, P. Jelinic, P. Watson, P. Francis, P. Russell, R. Pierce, R. Hills, R. Leon-Ferre, R. De Wind, R. Shui, S. Declercq, S. Leung, S. Tabbarah, Sandra C. Souza, S. O'toole, S. Swain, S. Willis, S. Ely, Seong-Rim Kim, S. Bedri, Sheeba Irshad, Shiwei Liu, S. Hendry, S. Bianchi, S. Bragança, S. Paik, S. Fox, S. Luen, S. Naber, Sua Luz, S. Fineberg, T. Soler, T. Gevaert, Timothy d’Alfons, T. John, Tomohagu Sugie, V. Bossuyt, V. Manem, Vincente Peg Cámaea, W. Tong, Wentao Yang, W. Tran, Yihong Wang, Y. Allory, Z. Husain   +257 more
semanticscholar   +1 more source

Digital Genomic Quantification of Tumor-Infiltrating Lymphocytes [PDF]

Science Translational Medicine, 2013
A digital DNA-based assay demonstrates an association between higher TIL counts and improved survival among women with ovarian cancer.
Kathy O'Briant, Muneesh Tewari, Nolan G. Ericson, Jamie Guenthoer, Jason H. Bielas, Jason H. Bielas, Harlan Robins, Charles W. Drescher   +7 more
openaire   +3 more sources

The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma.

PLoS ONE, 2019
The prognostic significance of tumor-infiltrating lymphocytes has been determined in cancers of the lung, colon and breast, though there is no standardized method for using this prognostic indicator for lung cancer.
Ahrong Kim, So Jeong Lee, Jihyun Ahn, Won Young Park, Dong Hoon Shin, Chang Hun Lee, Hoon Kwon, Yeon Joo Jeong, Hyo Yeong Ahn, Hoseok I, Yeong Dae Kim, Jeong Su Cho   +11 more
doaj   +1 more source

Characteristics of lymphocyte-infiltrating papillary thyroid cancer

Journal of Cancer Research and Practice, 2017
Background: The tumor-promoting or tumor-suppressing role of tumor-associated lymphocytes remains a subject of debate. We examined thyroid cancer data from The Cancer Genome Atlas in an attempt to define the relationship between lymphocyte infiltrates ...
Chi-Yu Kuo, Tsang-Pai Liu, Po-Sheng Yang, Shih-Ping Cheng   +3 more
doaj   +1 more source

Tumor-Infiltrating Lymphocytes and Prognosis: A Pooled Individual Patient Analysis of Early-Stage Triple-Negative Breast Cancers.

Journal of Clinical Oncology, 2019
PURPOSE The aim of the current study was to conduct a pooled analysis of studies that have investigated the prognostic value of tumor-infiltrating lymphocytes (TILs) in early-stage triple negative breast cancer (TNBC). METHODS Participating studies had
S. Loi, D. Drubay, S. Adams, G. Pruneri, P. Francis, M. Lacroix-Triki, H. Joensuu, M. Dieci, S. Badve, S. Demaria, R. Gray, E. Munzone, J. Lemonnier, C. Sotiriou, M. Piccart, P. Kellokumpu-Lehtinen, A. Vingiani, K. Gray, F. André, C. Denkert, R. Salgado, S. Michiels   +21 more
semanticscholar   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources

Simultaneous analysis of tumor-infiltrating immune cells density, tumor budding status, and presence of lymphoid follicles in CRC tissue

Scientific Reports, 2022
Colorectal cancer (CRC) affects more than 1,000,000 people worldwide each year. Recently, the number of young patients with early-onset colorectal cancer has increased, and right-sided colorectal cancer is still often diagnosed only in advanced stages ...
Adam R. Markowski, Anna J. Markowska, Wiktoria Ustymowicz, Anna Pryczynicz, Katarzyna Guzińska-Ustymowicz   +4 more
doaj   +1 more source

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]

, 2016
BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas, Chmielowski, Bartosz, Crompton, Joseph G, Dry, Sarah, Eilber, Fritz C, Federman, Noah, Jensen, Sarah, Li, Yunfeng, Nelson, Scott, Shurell, Elizabeth, Singh, Arun S, Tumeh, Paul   +11 more
core   +2 more sources