Results 101 to 110 of about 36,333 (238)

Chronic viral infections impaired the growth process of splenic B cells by upregulating Bbc3 and Atf3 in LCMV-CL13 infected mouse model

Virulence
Chronic persistent viral infections can lead to significant spleen damage, thus disrupting the host humoral immune response; however, the underlying mechanisms remain unclear. In this study, we employed a Lymphocytic choriomeningitis virus (LCMV) chronic
Zhe Li, Wei Yang, Fangzhou Cai, Dan Li, Qian Chen, Yiteng Zhang, Jiarui Cui, Wei Wang   +7 more
doaj   +1 more source

The impact of Foxp3+ regulatory T‐cells on CD8+ T‐cell dysfunction in tumour microenvironments and responses to immune checkpoint inhibitors

British Journal of Pharmacology, Volume 183, Issue 6, Page 1250-1270, March 2026.
Immune checkpoint inhibitors (ICIs) have been a breakthrough in cancer therapy, inducing durable remissions in responding patients. However, they are associated with variable outcomes, spanning from disease hyperprogression to complete responses with the onset of immune‐related adverse events.
Mikhaël Attias, Ciriaco A. Piccirillo
wiley   +1 more source

High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus

Emerging Infectious Diseases, 2010
Lymphocytic choriomeningitis virus (LCMV) is the prototype of the family Arenaviridae. LCMV can be associated with severe disease in humans, and its global distribution reflects the broad dispersion of the primary rodent reservoir, the house mouse (Mus ...
Cesar G. Albariño, Gustavo Palacios, Marina L. Khristova, Bobbie R. Erickson, Serena A. Carroll, James A. Comer, Jeffrey Hui, Thomas Briese, Kirsten St. George, Thomas G. Ksiazek, W. Ian Lipkin, Stuart T. Nichol   +11 more
doaj   +1 more source

Lysis mediated by T cells and restricted by H-2 antigen of target cells infected with vaccinia virus [PDF]

, 1975
VARIOUS virus infections lead to the formation of cytotoxic lymphocytes (CL), which are capable of killing virus-infected target cells1−4. Specific lysis of target cells infected with 51Cr-labelled vaccinia virus could be observed when investigating the ...
GJ Hämmerling, GM Shearer, H. ERTL, HR McFarland, I Gardner, LF Speel, M Nabholz, M Schlesinger, O Marker, RM Zinkernagel, RM Zinkernagel, RM Zinkernagel, RV Blanden, U. KOSZINOWSKI   +13 more
core   +1 more source

Viral Infection Results in Massive CD8+ T Cell Expansion and Mortality in Vaccinated Perforin-Deficient Mice [PDF]

, 1911
Perforin-mediated cytotoxicity is essential for clearance of primary LCMV infection. BALB/c-perforin-deficient (PKO) mice survived LCMV infection by deleting NP118-specific CD8+ T cells whereas vaccination of PKO mice with Listeria expressing NP118 ...
Badovinac, Vladimir P, Hamilton, Sara E, Harty, John T   +2 more
core   +1 more source

Infectious Lymphocytes in Lymphocytic Choriomeningitis Virus Carrier Mice

Journal of General Virology, 1979
The infectivity of blood and lymphoid organs of mice persistently infected with lymphocytic choriomeningitis virus was found to be predominantly associated with lymphocytes and both T and B cells were infectious. A hypothesis is presented in which it is assumed that lymphocytes in carrier mice are infected via their LCM virus-specific antigen receptors,
M, Popescu, J, Löhler, F, Lehmann-Grube
openaire   +2 more sources

H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus

Journal of Experimental Medicine, 1975
Maximal cell-mediated lysis of targets infected with lymphocytic choriomeningitis virus occurs only within a H-2 compatible system. Syngeneic immune spleen cells are at least 100 times as effective as are allogeneic lymphocytes. Reciprocal restriction of
Peter C. Doherty, R. Zinkernagel
semanticscholar   +1 more source

Pseudotyped Lentiviral Vectors: One Vector, Many Guises [PDF]

, 2017
Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene transfer to desired cells.
Joglekar, Alok V., Sandoval, Salemiz
core  

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes [PDF]

, 1990
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain
Jonjic, Stipan, Koszinowski, Ulrich H., Lucin, Pero, Pavic, Ivica, Rukavina, Daniel   +4 more
core  

Human Infection with Lymphocytic Choriomeningitis Virus

Emerging Infectious Diseases, 2010
Leslie L. Barton
doaj   +1 more source