Results 81 to 90 of about 36,333 (238)

BCR–ABL1 Drives Transcriptional Reprogramming of Chronic Myeloid Leukemia Cells for Immune Evasion Through C/EBPβ

MedComm, Volume 7, Issue 5, May 2026.
There is global immunosuppression during CML initiation and progression, which is directly driven by BCR–ABL1 expressing CML cells. On one hand, the BCR–ABL1 oncogene drives the differentiation of leukemia cells toward the neutrophil lineage. On the other hand, the oncogene also transcriptionally activates master immune regulators, including arginase ...
Xiaocui Lu, Hui Fang, Yuan Liu, Chang Liu, Xuexiu Fang, Atsuko Matsunaga, Stephanie F. Mori, Ting Zhang, Gavin Wang, George I. Zhou, Miao Yu, Haocheng Ding, Jorge Cortes, Bo Cheng, Tianxiang Hu   +14 more
wiley   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

Lymphocytic choriomeningitis virus meningitis after needlestick injury: a case report

Antimicrobial Resistance and Infection Control, 2019
Background Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel.
Sarah Dräger, Anna-Friederike Marx, Fiona Pigny, Pascal Cherpillod, Philip Eisermann, Parham Sendi, Andreas F. Widmer   +6 more
doaj   +1 more source

IRF4 and BATF are critical for CD8(+) T-cell function following infection with LCMV. [PDF]

, 2014
CD8(+) T-cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses, beneficial destruction of infected cells must be balanced against immunopathology resulting from collateral damage ...
Bode, J., Crome, S.Q., Dress, R.J., Elford, A.R., Grusdat, M., Hamilton, S.R., Huber, M., Häussinger, D., Knievel, J., Lang, E., Lang, K.S., Lang, P.A., Lohoff, M., Mak, T.W., Maney, S.K., McIlwain, D.R., Mittrücker, H.W., Ohashi, P.S., Pandyra, A.A., Pfeffer, K., Pozdeev, V.I., Robert-Tissot, C., Scheu, S., Speiser, D.E., Xu, H.C.   +24 more
core   +1 more source

PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 20, 9 April 2026.
The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao, Lijuan Lu, Xiaoxiao Xiong, Yi Li, Donghui Hu, Duo Zhang, Zhiwei Feng, Cong Liu, Nannan Liu, Xiaoli Li, Jizhou Tan, Ting Liu, Ling Peng, Lu Lu, Huiyi Feng, Yan Zhong, Guisen Tan, Zhicheng Zhang, Liqin Huang, Chao Su, Ying Xue, Shuo Song, Wenxia Fan, Wei Wang, Fan Zou   +24 more
wiley   +1 more source

Pseudotyping Vesicular Stomatitis Virus with Lymphocytic Choriomeningitis Virus Glycoproteins Enhances Infectivity for Glioma Cells and Minimizes Neurotropism

Journal of Virology, 2011
Vesicular stomatitis virus (VSV)-based oncolytic virotherapy has the potential to significantly improve the prognosis of aggressive malignancies such as brain cancer. However, VSV's inherent neurotoxicity has hindered clinical development so far.
A. Muik, Inna Kneiske, Marina Werbizki, D. Wilflingseder, Tsanan Giroglou, O. Ebert, Anna Kraft, U. Dietrich, G. Zimmer, S. Momma, D. von Laer   +10 more
semanticscholar   +1 more source

Increased Constitutive Interferon‐β Levels and Altered CD4 T Cell Homeostasis Induced by Expression of a Viral Glycoprotein

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Constitutive interferon (IFN) production is regulated by microbiota and essential for optimal immune responses. Here, we demonstrate that expression of the glycoprotein of LCM virus upregulates constitutive IFN‐β levels and IFN‐stimulated genes (ISGs) in transgenic mice.
Hanspeter Pircher, Oliver S. Thomas, Anne S. Haefke, Annette Oxenius, Thomas Boehm   +4 more
wiley   +1 more source

Type 1 Interferon Induction of Natural Killer Cell Gamma Interferon Production for Defense during Lymphocytic Choriomeningitis Virus Infection

mBio, 2011
Natural killer (NK) cells are equipped to innately produce the cytokine gamma interferon (IFN-γ) in part because they basally express high levels of the signal transducer and activator of transcription 4 (STAT4).
Ethan A Mack, Lara E. Kallal, D. Demers, C. Biron   +3 more
semanticscholar   +1 more source

Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries

Viruses, 2019
Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological ...
Mohamed S. Abdel-Hakeem
doaj   +1 more source

Fibrinogen‐Like Protein 2 Modulates B Cell Mucosal Immunity by Suppressing Receptor for Activated C‐Kinase 1‐Mediated AKT Phosphorylation

MedComm, Volume 7, Issue 4, April 2026.
In our study, B cells are activated with the assistance of Breg and Tfh cells, subsequently differentiating into IgA+ plasma cells. These plasma cells produce secretory IgA (sIgA) at mucosal surfaces to combat viral and parasitic infections. Mechanistically, Fgl2 directly binds to Rack1.
Jiang Chang, Da Huang, Wei Yuan, Jianing Tang, Jingzhi Yang, Yuying Chen, Zhize Yuan, Yizhi Wu, Di Wu, Weiming Yan, Qin Ning   +10 more
wiley   +1 more source