Results 61 to 70 of about 36,333 (238)

Gene therapy of malignant glioma with retroviral vectors and tumor-infiltrating progenitor cells [PDF]

, 2008
Gene therapy as a therapeutic strategy in the treatment of human gliomas is limited by the efficacy of gene transfer and intratumoral distribution of viral vectors.
Miletic, Hrvoje
core  

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Independent Lineage of Lymphocytic Choriomeningitis Virus in Wood Mice (Apodemus sylvaticus), Spain

Emerging Infectious Diseases, 2009
To clarify the presence of lymphocytic choriomeningitis virus (LCMV) in Spain, we examined blood and tissue specimens from 866 small mammals. LCMV RNA was detected in 3 of 694 wood mice (Apodemus sylvaticus).
Juan Ledesma, Cesare Giovanni Fedele, Francisco Carro, Lourdes Lledó, María Paz Sánchez-Seco, Antonio Tenorio, Ramón Casimiro Soriguer, José Vicente Saz, Gerardo Domínguez, María Flora Rosas, Jesús Félix Barandika, María Isabel Gegúndez   +11 more
doaj   +1 more source

Identification of potential novel hosts and the risk of infection with lymphocytic choriomeningitis virus in humans in Gabon, Central Africa

International Journal of Infectious Diseases, 2021
Objectives: Lymphocytic choriomeningitis virus (LCMV), a human pathogenic arenavirus, is distributed worldwide. However, no human cases have been reported in Africa.
Yuri Ushijima, Haruka Abe, Takehiro Ozeki, Georgelin N. Ondo, Marien J.V.M. Mbadinga, Rodrigue Bikangui, Chimène Nze-Nkogue, Etienne F. Akomo-Okoue, Ghislain W.E. Ella, Lilian B.M. Koumba, Branly C.B.B. Nso, Rodrigue Mintsa-Nguema, Patrice Makouloutou-Nzassi, Boris K. Makanga, Fred L.M. Nguelet, Vahid R. Zadeh, Shuzo Urata, Armel V.N. Mbouna, Marguerite Massinga-Loembe, Selidji T. Agnandji, Bertrand Lell, Jiro Yasuda   +21 more
doaj   +1 more source

T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner [PDF]

, 2017
Viral infection of the central nervous system can lead to disability and death. Yet the majority of viral infections with central nervous system involvement resolve with only mild clinical manifestations, if any. This is generally attributed to efficient
Bergthaler, Andreas, Brück, Wolfgang, Horvath, Edit, Löhning, Max, Merkler, Doron, Pinschewer, Daniel D., Schedensack, Mariann   +6 more
core  

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, Volume 20, Issue 5, Page 1093-1097, May 2026.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Role of Lymphocytic Choriomeningitis Virus (LCMV) in Understanding Viral Immunology: Past, Present and Future

Viruses, 2012
Lymphocytic choriomeningitis virus (LCMV) is a common infection of rodents first identified over eighty years ago in St. Louis, MO, U.S.A. It is best known for its application in immunological studies.
Xin Zhou, Srividya Ramachandran, Margaret W. Mann, Daniel L. Popkin   +3 more
semanticscholar   +1 more source

Innate and adaptive immune control of genetically engineered live-attenuated arenavirus vaccine prototypes [PDF]

, 2017
Arenaviruses such as Lassa virus (LASV) cause significant morbidity and mortality in endemic areas. Using a glycoprotein (GP) exchange strategy, we have recently developed live-attenuated arenavirus vaccine prototypes (rLCMV/VSVG) based on lymphocytic ...
Bergthaler, Andreas, Fernandez, Marylise, Flatz, Lukas, Horvath, Edit, Lutz, Hans, Pinschewer, Daniel D., Steinborn, Ralf, Suter, Mark   +7 more
core  

CD8 T Cell Sensing of Type I Interferon Impacts Anergy

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Basal IFN‐I acts as a rheostat to fine‐tune CD8 T cell anergy. The presence of IFN‐I induces a less deep anergic state characterised by greater expansion, residual effector function and plasticity. This favours the accumulation of autoreactive T cells that retain the potential to break tolerance rather than undergoing deletion.
Anne S. Haefke, Hanna Gröber, Ioana Sandu, Vanessa Skipness, Nikos Pantouloufos, Fabienne Gräbnitz, Marie‐Elen Tuchel, Nathan Zangger, Dominique Stark, Marvin Kříž, Carmine Cristinzio, Hanspeter Pircher, Roman Spörri, Isaak Quast, Annette Oxenius   +14 more
wiley   +1 more source

Cell surface molecules involved in infection mediated by lymphocytic choriomeningitis virus glycoprotein.

Journal of Veterinary Medical Science, 2012
The glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), the prototype arenavirus, is a promising envelope protein of lentiviral pseudotype vectors for gene therapy.
M. Shimojima, Y. Kawaoka
semanticscholar   +1 more source