Results 61 to 70 of about 16,718 (165)

Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries

Viruses, 2019
Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological ...
Mohamed S. Abdel-Hakeem
doaj   +1 more source

The Developmental and Functional Implications of Age‐Associated B Cells (ABCs) Across Tissue Microenvironments

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Age‐associated B cells (ABCs) are a dynamic B cell subset whose identity, development, and function are fundamentally shaped by the tissue microenvironments in which they reside. Primarily defined by expression of CD11c and T‐bet, ABCs arise across diverse contexts, including aging, infection, autoimmunity, and cancer, yet exhibit striking ...
Rebecca L. Francis, Jason S. Weinstein
wiley   +1 more source

Dendritic cell‐specific hypoxia‐inducible factor‐1α deficiency protects mice from recurrent retroviral infection

Experimental Physiology, Volume 111, Issue 8, Page 3843-3856, 1 August 2026.
Abstract Antigen‐processing and ‐presenting cells play a pivotal role in initiation of the antiviral immune response. The cellular adaption of dendritic cells to reduced oxygen and nutrition levels at the site of infection is regulated predominantly by the transcription factor complex hypoxia‐inducible factor‐1 (HIF‐1).
Timm Schreiber, Yvonne Hüsecken, Claudia Lodewick, Simone Schimmer, Gennadiy Zelinskyy, Ulf Dittmer, Kathrin Sutter, Joachim Fandrey, Sandra Winning   +8 more
wiley   +1 more source

Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease.

PLoS Pathogens, 2012
The viral family Arenaviridae includes a number of viruses that can cause hemorrhagic fever in humans. Arenavirus infection often involves multiple organs and can lead to capillary instability, impaired hemostasis, and death.
Frederick J Schnell, Sarah Sundholm, Stacy Crumley, Patrick L Iversen, Dan V Mourich   +4 more
doaj   +1 more source

Chronic viral infections impaired the growth process of splenic B cells by upregulating Bbc3 and Atf3 in LCMV-CL13 infected mouse model

Virulence
Chronic persistent viral infections can lead to significant spleen damage, thus disrupting the host humoral immune response; however, the underlying mechanisms remain unclear. In this study, we employed a Lymphocytic choriomeningitis virus (LCMV) chronic
Zhe Li, Wei Yang, Fangzhou Cai, Dan Li, Qian Chen, Yiteng Zhang, Jiarui Cui, Wei Wang   +7 more
doaj   +1 more source

Cell Culture and Electron Microscopy for Identifying Viruses in Diseases of Unknown Cause

Emerging Infectious Diseases, 2013
During outbreaks of infectious diseases or in cases of severely ill patients, it is imperative to identify the causative agent. This report describes several events in which virus isolation and identification by electron microscopy were critical to ...
Cynthia S. Goldsmith, Thomas G. Ksiazek, Pierre E. Rollin, James A. Comer, William L. Nicholson, Teresa C.T. Peret, Dean D. Erdman, William J. Bellini, Brian H. Harcourt, Paul A. Rota, Julu Bhatnagar, Michael D. Bowen, Bobbie R. Erickson, Laura K. McMullan, Stuart T. Nichol, Wun-Ju Shieh, Christopher D. Paddock, Sherif R. Zaki   +17 more
doaj   +1 more source

Identification of the Virus of Lymphocytic Choriomeningitis [PDF]

Journal of Bacteriology, 1941
J E, Smadel, M J, Wall
openaire   +2 more sources

High Diversity and Ancient Common Ancestry of Lymphocytic Choriomeningitis Virus

Emerging Infectious Diseases, 2010
Lymphocytic choriomeningitis virus (LCMV) is the prototype of the family Arenaviridae. LCMV can be associated with severe disease in humans, and its global distribution reflects the broad dispersion of the primary rodent reservoir, the house mouse (Mus ...
Cesar G. Albariño, Gustavo Palacios, Marina L. Khristova, Bobbie R. Erickson, Serena A. Carroll, James A. Comer, Jeffrey Hui, Thomas Briese, Kirsten St. George, Thomas G. Ksiazek, W. Ian Lipkin, Stuart T. Nichol   +11 more
doaj   +1 more source

Infectious Lymphocytes in Lymphocytic Choriomeningitis Virus Carrier Mice

Journal of General Virology, 1979
The infectivity of blood and lymphoid organs of mice persistently infected with lymphocytic choriomeningitis virus was found to be predominantly associated with lymphocytes and both T and B cells were infectious. A hypothesis is presented in which it is assumed that lymphocytes in carrier mice are infected via their LCM virus-specific antigen receptors,
M, Popescu, J, Löhler, F, Lehmann-Grube
openaire   +2 more sources

Innate immune activation profiles are associated with polarization of the T cell response to recombinant arenaviral vectors

Frontiers in Systems Biology
Arenavirus-based vectors are uniquely positioned to generate durable T cell responses against tumors, which remains a central challenge in cancer immunotherapy.
Sarah Szaffich, Sarah Szaffich, Valentin Just, Natalija Cvetkovic, Naila Pepic, Michael Schwendinger, Kia Katchar, Klaus K. Orlinger, Henning Lauterbach, Josipa Raguz, Katell Bidet Huang   +10 more
doaj   +1 more source