Results 51 to 60 of about 16,718 (165)

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Microbial Signals in Cancer: Dissecting Host–Microbiota–Tumor Interactions and Potential Therapeutic Strategy

MedComm, Volume 7, Issue 9, September 2026.
Microbial signals from gut and tumor‐resident bacteria, fungi, viruses, and bacteriophages reshape immune and metabolic networks within the tumor microenvironment, thereby influencing cancer progression, treatment response. Therapeutic modulations, including dietary interventions, probiotics, antibiotics, fecal microbiota transplantation, engineered ...
Juan Lu, Mengjuan Xuan, Liang Yu, Zhongyang Xie, Qingfei Chu, Shihui Wei, Tuokai Wang, Chen Xue, Lanjuan Li   +8 more
wiley   +1 more source

In the Midst of a Cytokine Storm—The Hemophagocytic Syndrome (Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome)

Veterinary Clinical Pathology, Volume 55, Issue 3, Page 422-437, September 2026.
ABSTRACT Background Hemophagocytic syndrome (HPS)/hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory syndrome characterized by immune dysregulation, cytokine overproduction, hemophagocytosis, cytopenias, and multiorgan dysfunction.
Joanne B. Messick
wiley   +1 more source

Properties of Defective Lymphocytic Choriomeningitis Virus

Journal of General Virology, 1972
Summary The symptoms and histopathology of many virus diseases depend not so much on damage to the cells by virus but on the immunological reaction to the infection. The earliest (Traub, 1935) and still extensively studied (Oldstone & Dixon, 1970) infection of this type is murine lymphocytic choriomeningitis.
R M, Welsh, C M, O'Connell, C J, Pfau
openaire   +2 more sources

Strategies for inducing diabetes in laboratory animals: Advances from chemical, surgical, immunologic, dietary, and genetic approaches

Animal Models and Experimental Medicine, Volume 9, Issue 8, Page 1548-1566, August 2026.
This review summarizes the principal experimental approaches used to induce diabetes in animal models. Strategies include chemical agents (streptozotocin, alloxan, dithizone, gold thioglucose), dietary interventions (high‐fat and high‐sugar diets), surgical methods (total or partial pancreatectomy), genetic models (db/db, ob/ob, Goto‐Kakizaki [GK ...
Milad Faraji, Maedeh Faraji, Nasrin Kazemipour   +2 more
wiley   +1 more source

Lymphocytic choriomeningitis virus meningitis after needlestick injury: a case report

Antimicrobial Resistance and Infection Control, 2019
Background Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel.
Sarah Dräger, Anna-Friederike Marx, Fiona Pigny, Pascal Cherpillod, Philip Eisermann, Parham Sendi, Andreas F. Widmer   +6 more
doaj   +1 more source

A Bacterial Microbiome Is Dispensable for the Induction of CD8 T Cell Exhaustion

European Journal of Immunology, Volume 56, Issue 8, August 2026.
We infected Germ‐free and normal SPF mice infected with strains of LCMV that cause chronic infections. In both types of mice, T cell exhaustion progressed to similar levels. Thus, the microbiome is dispensable for the induction of T cell exhaustion.
Miriam Kuhlmann, Daphne Del Carmen Kolland, Gustavo Pereira de Almeida, Christian Hoffmann, Madlaina von Hoesslin, Jacqueline Berner, Christine Wurmser, Anna Akulich, Anna M. Schulz, Carl‐Philipp Hackstein, Caspar Ohnmacht, Dietmar Zehn   +11 more
wiley   +1 more source

Lymphocytic choriomeningitis virus: invisible but not innocent

Acta virologica, 2013
Lymphocytic choriomeningitis virus (LCMV) attracts significant attention both as an important experimental model system to study acute and persistent viral infections, and as a neglected human pathogen of clinical significance. This review focuses on the basic aspects and recent advances in the molecular and cell biology of LCMV, the outcome of LCMV ...
K, Lapošová, S, Pastoreková, J, Tomášková   +2 more
openaire   +3 more sources

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Interferon‐Mediated Regulation of Memory B Cell Identity and Function

Immunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT Memory B cells are essential for long‐lasting immunity induced by both encountered pathogens and vaccines. Functional diversity within the memory B cell pool is established through interactions between memory B cells and the environment in which they develop and reside.
Alana Kirn, Kim L. Good‐Jacobson
wiley   +1 more source