Results 71 to 80 of about 36,333 (238)

Лимфоцитен хориоменингит – клиничен случай

Българска неврология, 2023
Lymphocytic choriomeningitis virus е един от причинителите на неврологични заболявания при хора. Заразяването с вируса се осъществява посредством контакт с миши екскременти.
Sashka Zhelyazkova, A. Taneva, S. Cherninkova, I. Tournev   +3 more
doaj  

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis [PDF]

, 1976
Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL).
Bevan, Canty, Doherty, Doherty, Ertl, Forman, Gordon, Herberman, Koszinowski, Pfizenmaier, Pfizenmaier, Pfizenmaier, Shearer, Shreffler, Wagner, Wekerle, Zinkernagel   +16 more
core   +1 more source

Suppression of Calcium Influx Reduces Coxsackievirus B3 Lethality With Elevated Interferon Beta Responses in Mice

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The disease course of severe enterovirus (EV) infection with hepatic necrosis is usually fulminant and fatal. Coxsackievirus (CVB3) is the emerging and important serotype of newborn EV inducing hepatic necrosis. Calcium (Ca2+) regulates host immunity, type I interferon (IFN‐I), and viral infections.
Yi‐Ling Hsiao, Cheng‐Huei Hung, Ming Te Yeh, Shun‐Hua Chen   +3 more
wiley   +1 more source

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival. [PDF]

, 2016
Chronic infections induce T cells showing impaired cytokine secretion and up-regulated expression of inhibitory receptors such as PD-1. What determines the acquisition of this chronic phenotype and how it impacts T cell function remain vaguely understood.
Alter, Angelosanto, Badovinac, Barber, Battegay, Bengsch, Bengsch, Beura, Blackburn, Blackburn, Chu, Cornberg, Daniel D. Pinschewer, Daniel T. Utzschneider, David Barras, Day, Dietmar Zehn, Doedens, Elsaesser, Enouz, Flatz, Flatz, Francesca Alfei, Frebel, Fröhlich, Harari, Hertoghs, Jin, Jin, Johnson, Klenerman, Kunz, Legat, Lichterfeld, Matloubian, Mauro Delorenzi, Moskophidis, Mueller, Murali-Krishna, Nakamoto, Odorizzi, Paley, Patrick Roelli, Pauken, Pircher, Puglielli, Radziewicz, Schietinger, Schmitz, Sevilla, Smelt, Speiser, Stephanie Darbre, Utzschneider, Viganò, Vijaykumar Chennupati, Virgin, Wherry, Wherry, Wherry, Williams, Yi, Zajac, Zehn, Zehn, Zehn, Zehn   +66 more
core   +2 more sources

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Replicating viral vector platform exploits alarmin signals for potent CD8⁺ T cell-mediated tumour immunotherapy. [PDF]

, 2017
Viral infections lead to alarmin release and elicit potent cytotoxic effector T lymphocyte (CTL ^eff ) responses. Conversely, the induction of protective tumour-specific CTL ^eff and their recruitment into the
A Hyvarinen, A Plyusnin, A Wortmann, AM Henao-Restrepo, C Baumann, C Butts, CA Klebanoff, CB Stephensen, D Peng, D Valmori, D Zamarin, DA Enria, DK Reichenbach, DL Popkin, E Scandella, ER Chare, F Duan, F Pages, F Spertini, GP Dunn, HE Webb, J Delaloye, J Liu, J Zhu, JA Joyce, JF Vansteenkiste, JY Liu, K Oboki, KM Quinn, L Flatz, L Flatz, L Flatz, L Zhang, LC Anton, M Lewandoski, M Peine, M Perez, M Suter, M Vanneman, MD Stenglein, MF Callan, MF Kotturi, MJ Townsend, N Fasnacht, O Kew, P Grob, P Sharma, PC Doherty, PC Tumeh, PW Kantoff, R Schirmbeck, R Sommerstein, RH Andtbacka, RM Zinkernagel, RM Zinkernagel, S Darbre, S Spranger, SA Fuertes Marraco, SA Rosenberg, SF Emonet, SG Hansen, SN Mueller, T Querec, TF Gajewski, TN Schumacher, WV Bonilla, WV Bonilla, X de Lamballerie, Y Iwai, Z Waibler   +69 more
core   +2 more sources

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Lymphocytic Choriomeningitis Virus Alters the Expression of Male Mouse Scent Proteins

Viruses, 2021
Mature male mice produce a particularly high concentration of major urinary proteins (MUPs) in their scent marks that provide identity and status information to conspecifics.
Michael B. A. Oldstone, Brian C. Ware, Amanda Davidson, Mark C. Prescott, Robert J. Beynon, Jane L. Hurst   +5 more
doaj   +1 more source

PD-1 signaling promotes control of chronic viral infection by restricting type-I-interferon-mediated tissue damage [PDF]

, 2019
Immune responses are essential for pathogen elimination but also cause tissue damage, leading to disease or death. However, it is unclear how the host immune system balances control of infection and protection from the collateral tissue damage.
Egawa, Takeshi, Raju, Saravanan, Verbaro, Daniel J   +2 more
core   +1 more source

Arenavirus budding resulting from viral-protein-associated cell membrane curvature [PDF]

, 2013
Viral replication occurs within cells, with release (and onward infection) primarily achieved through two alternative mechanisms: lysis, in which virions emerge as the infected cell dies and bursts open; or budding, in which virions emerge gradually from
Abelson HT, Benjamin W. Neuman, Cheng RH, Coronel EC, Dalton A, David Schley, Dawkins R, Ghosal S, Harty RN, Justice PA, Lehmann-Grube F, Li Y, Murphy FA, Press WH, Puffer BA, Robert J. Whittaker, Schalich J, Suomalainen M, Weldon R   +18 more
core   +1 more source