Results 81 to 90 of about 22,112 (212)

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real‐world study

International Journal of Cancer, Volume 158, Issue 10, Page 2674-2683, 15 May 2026.
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang, Jing‐jing Sun, Zhi Wan, Xiao‐yu Jing, Xia Guo, Ju Gao   +5 more
wiley   +1 more source

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in a ten-year-old girl accompanied by posterior reversible encephalopathy syndrome and disseminated herpes simplex virus infection [PDF]

, 2015
　可逆性後頭葉白質脳症は通常臨床的には頭痛・痙攣・視覚障害等の神経症状で発症するしばしば認める疾患である．一方，播種性ヘルペス感染症は免疫不全患者で認める感染症である．今回我々は，EBウイルス関連血球貪食症候群に対するエトポシド・プレドニゾロン・シクロスポリンを用いた多剤併用化学療法中に，シクロスポリン関連可逆性後頭葉白質脳症と播種性ヘルペス感染症と診断された10歳女児を経験したので報告する．EBウイルス関連血球貪食症候群に対する併用療法は当初有効であったが ...
板倉 隆太, 森脇 浩一, 浅野 祥孝, 田村 正徳, 荒川 歩, 難波 文彦   +5 more
core  

Fixed‐Duration Subcutaneous Mosunetuzumab in Relapsed/Refractory Follicular Lymphoma: Pivotal Phase 2 Primary Analysis

American Journal of Hematology, Volume 101, Issue 5, Page 986-997, May 2026.
ABSTRACT Mosunetuzumab is approved as an intravenous (IV) formulation for relapsed/refractory (R/R) follicular lymphoma (FL) after ≥ 2 prior therapies. A subcutaneous (SC) formulation, aiming to improve patient safety and convenience, has been developed.
Nancy L. Bartlett, Laurie H. Sehn, Sarit Assouline, Pratyush Giri, John Kuruvilla, Stephen J. Schuster, Sung‐Soo Yoon, Keith Fay, Georg Hess, Martin Dreyling, Norma C. Gutierrez, Eva Cybulski, Fidelis Sabalvaro, Elicia Penuel, Vanda Teodoro, Samuel Tracy, Denison Kuruvilla, Joseph Chen, Volker Wiebking, Michael C. Wei, L. Elizabeth Budde   +20 more
wiley   +1 more source

Défaut d’exocytose des granules lytiques : Plusieurs causes, un même effet [PDF]

, 2006
Une réponse immune exagérée, incontrôlée et le plus souvent fatale, connue sous le nom de syndrome hémophagocytaire (SH), est associée à un défaut de la fonction cytotoxique des lymphocytes T et natural killer (NK).
de Saint Basile, Geneviève, Fischer, Alain, Le Deist, Françoise, Ménager, Mickaël, Ménasché, Gaël   +4 more
core  

An Unusual Case of Classic Hodgkin Lymphoma With Strong Expression of B‐Cell Markers

International Journal of Laboratory Hematology, EarlyView.
Christopher Liwski, Sorin Selegean, Allam Shawwa, David M. Conrad   +3 more
wiley   +1 more source

Different Immune Cells Modified With Chimeric Antigen Receptors Are Being Applied to Ovarian Cancer: Which Is the Most Effective?

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Ovarian Cancer (OC), the deadliest gynecological malignancy, poses a major therapeutic challenge in advanced stages owing to its high recurrence rate and metastatic potential. In this regard, it is noteworthy that immunotherapy has recently gained significant attention in OC treatment, a phenomenon attributable to notable advances in over‐the ...
Liying Wang, Yisen Cao, Yuan Ren, Yuhang Zhang, Liang Wang   +4 more
wiley   +1 more source

Macrophage Activation Syndrome [PDF]

, 2015
Macrophage activation syndrome (MAS) is a potentially life-threatening complication of rheumatic diseases such as systemic juvenile idiopathic arthritis (sJIA) and systemic lupus erythematosus.
Clarke, Sarah L N, Ramanan, Athimalaipet V, Sen, Ethan S   +2 more
core   +2 more sources

Severe Adult HLH/MAS With SPTCL‐Like Panniculitis: A Phenotype‐Guided, Resource‐Adapted Therapeutic Strategy Without Cytotoxic Therapy

Clinical Case Reports, Volume 14, Issue 5, May 2026.
Graphical abstract illustrating the phenotype‐guided therapeutic approach in severe adult HLH/MAS with SPTCL‐like panniculitis, demonstrating clinical and biochemical response following sequential treatment with therapeutic plasma exchange, intravenous immunoglobulin, and cyclosporine.
Hatem Mousa Taha, Omar Marouf, Khaled Hatem Taha   +2 more
wiley   +1 more source

Secondary hemophagocytic lymphohistiocytosis in children with brucellosis: report of three cases

Journal of Infection in Developing Countries, 2015
Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy. It continues to be an important health problem worldwide.
Yöntem Yaman, Salih Gözmen, Ahmet Kağan Özkaya, Yeşim Oymak, Hurşit Apa, Canan Vergin, İlker Devrim   +6 more
doaj   +1 more source

Phagocytic Mesothelial Cells in Pericardial Effusion Following Allogeneic Peripheral Blood Stem Cell Transplantation for Chronic Active Epstein–Barr Virus Infection: A Distinctive Cytomorphological and Immunocytochemical Case Study

Diagnostic Cytopathology, Volume 54, Issue 5, Page E136-E139, May 2026.
ABSTRACT Phagocytic activity of mesothelial cells is a rare phenomenon requiring careful differentiation from histiocytic hemophagocytosis to ensure appropriate patient management, as these phenomena could exhibit distinct clinical implications. In this study, we report a case of phagocytic mesothelial cells found in pericardial effusion that developed
Hidetoshi Satomi, Ayumi Ryu, Sei Murayama, Hiroya Kojima, Satoshi Tanada, Keiichiro Honma   +5 more
wiley   +1 more source