Results 101 to 110 of about 20,160 (224)

The IL‐10/IL‐6 Ratio and the Risk Score: Two Cytokines‐Based Predictors for Malignancy‐Associated Hemophagocytic Lymphohistiocytosis in Adults (M‐HLHa)

American Journal of Hematology, Volume 101, Issue 9, Page 2214-2224, September 2026.
ABSTRACT The predictive value of cytokines (CK) for malignancy‐associated adult hemophagocytic lymphohistiocytosis (M‐HLHa) remains uncertain. We evaluated a cytokine‐based Risk Score (RS) and the IL‐10/IL‐6 Ratio to predict M‐HLHa. Adult patients (n = 112) from the French HLH cohort (NCT02113917) with complete data for nine key HLH related CK measured
Coralie Bloch, Stephanie Chhun, Nanthara Sritharan, Marine Gil, Raphael Lhote, Marouane Boubaya, Olivier Lambotte, David Launay, Claire Larroche, Estibaliz Lazaro, Francois Liffermann, Marc Michel, Jean‐Marie Michot, Pierre Morel, Louis Terriou, Geoffrey Urbansk, Jean‐Francois Viallard, Morgane Cheminant, Felipe Suarez, Yves Lepelletier, Geneviève de Saint Basile, Olivier Hermine, the French HLH Study Group, Coralie Bloch, Jean Philippe Jais, Francois Liffermann, Pierre Morel, Morgane Cheminant, Felipe Suarez, Olivier Hermine, Fabrice Bonnet, Pascal Godemer, Damaj Gandhi, Olivier Fain, Olivier Lambotte, David Launay, Louis Terriou, Claire Larroche, Estibaliz Lazaro, Jean‐Francois Viallard, Francois Liffermann, Olivier Lortholary, Marc Michel, Jean‐Marie Michot, Pierre Morel, Frederic Pene, Antoinette Perlat, Geoffrey Urbanski   +47 more
wiley   +1 more source

Secondary Dengue Infection Complicated by Hemophagocytic Lymphohistiocytosis: A Case Report

Case Reports in Infectious Diseases
Hemophagocytic lymphohistiocytosis is a fatal hyperinflammatory disorder in which CD8+ cytotoxic T-cells, natural killer cells, and macrophages destroy hematopoietic cells and vital organs. Viral infections, such as Epstein–Barr virus, are known to cause
Dominique D. Davis, Saffett Guleryuz, Yehuda Galili, Pablo A. Bejarano   +3 more
doaj   +1 more source

Secondary hemophagocytic lymphohistiocytosis in a child with Leptospira infection: A case report

The Turkish Journal of Pediatrics, 2018
Leptospirosis caused by spirochetes of the genus Leptospira in most patients result in very mild illness without jaundice. However, a small portion of patients develop various complications due to the involvement of multiple organ systems ...
Dragana Jevtic, Dragomir Djokic, Danka Redzic, Dragana Aleksic, Miro Parezanovic, Srdjan Pasic   +5 more
doaj   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1961-1974, September 2026.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

Treatment-refractory immune checkpoint inhibitor-induced hemophagocytic lymphohistiocytosis in the setting of adjuvant pembrolizumab for resected stage IIC melanoma: a case report

Journal of Medical Case Reports
Background Hemophagocytic lymphohistiocytosis is rare and does not have any distinct clinical features or laboratory abnormalities, whereby a high index of suspicion is required for diagnosis.
Kar Ven Cavan Chow, Kimberley Mui, Stewart Hunt, Chun Loo Gan   +3 more
doaj   +1 more source

Hemophagocytic lymphohistiocytosis presenting in a pediatric patient with near total colonic and small bowel aganglionosis: a case report

Journal of Medical Case Reports, 2017
Background Total colonic and small bowel aganglionosis is a rare condition typically requiring intestinal transplant for long-term survival. There have not been any previously reported cases of near total intestinal aganglionosis complicated by concerns ...
Brittany Badal, Michael J. Wilsey, Sara Karjoo   +2 more
doaj   +1 more source

Spinal Cord Involvement In A Child With Familial Hemophagocytic Lymphohistiocytosis

, 2012
The involvement of the central nervous system (CNS) in familial hemophagocytic lymphohistiocytosis (FHL) has known to be limited to the brain, brain stem, and cerebellum.
Cetin, Mualla, Gumruk, Fatma, Gokce, Muge, Balta, Gunay, Oguz, Kader, Unal, Sule   +5 more
core   +1 more source

Association of Ferritin Levels With Cytokine Release Syndrome in CAR T‐Cell Therapy: A Systematic Review and Meta‐Analysis

Cancer Medicine, Volume 15, Issue 9, September 2026.
CAR T‐cell infusion can induce production of excessive cytokines resulting in cytokine release syndrome (CRS). Ferritin is elevated in severe CRS and both pre‐ and post‐infusion levels are associated with poor survival. ABSTRACT Background Ferritin elevation is frequently observed during cytokine release syndrome (CRS) following CAR T‐cell therapy ...
Ranjit Sah, Abhinav Bhattarai, Sangam Shah, Rachana Mehta, Sanjit Sah, Zeeshan Solangi, George P. Sorescu   +6 more
wiley   +1 more source

Human Bocavirus: Can It Trigger Hemophagocytic Lymphohistiocytosis?

, 2017
With improvements in molecular diagnostic methods, report of Human bocavirus (HBoV) as an etiologic agent in many studies on viral respiratory and gastrointestinal infections has been increasing.
CEYHAN, MEHMET, ÖZSÜREKCİ, YASEMİN, Mehmet Ceyhan, Bajin, Inci, Sevgen Tanir Basaranoglu, AYKAÇ, KÜBRA, GÜMRÜK, FATMA, Kubra Aykac, Betul Tavil, Tavil, Betul, Fatma Gumruk, Yasemin Ozsurekci, TANIR BAŞARANOĞLU, SEVGEN, Inci Bajin   +13 more
core   +1 more source

Adult cancer-related hemophagocytic lymphohistiocytosis – a challenging diagnosis: a case report

Journal of Medical Case Reports, 2017
Background Adult hemophagocytic lymphohistiocytosis is a secondary immunopathologic phenomenon, mainly secondary to malignancy, infection, or autoimmune disorders.
Michael A. Hust, Boris R. A. Blechacz, Diana L. Bonilla, Naval Daver, Cristhiam M. Rojas-Hernandez   +4 more
doaj   +1 more source