Results 11 to 20 of about 415,767 (291)

Production of recombinant antibodies in lymphoid and non‐lymphoid cells [PDF]

FEBS Letters, 1993
A recombinant tandem of ‘chimeric’ mouse/human immunoglobulin (Ig) genes was constructed and inserted into plasmid pGEM 1 under the control of the T7 bacteriophage RNA polymerase promoter. Lymphoid (Sp2/0) and non‐lymphoid (CHO) cell lines used for transfection contained in their genomes a semisynthetic gene of T7 RNA polymerase and steadily expressed ...
Deyev, Sergey M., Lieber, Andre, Radko, Boris V., Polanovsky, Oleg L.   +3 more
openaire   +4 more sources

Simulation and Statistical Techniques to Explore Lymphoid Tissue Organogenesis [PDF]

, 2012
Secondary lymphoid organs have a key role in the initiation of adaptive immune responses to infection. Organogenesis occurs in foetal development, and the use of genetic tools, imaging technologies, and ex vivo culture systems has provided significant ...
Alden, Kieran
core   +6 more sources

Using cell-free RNA to identify B- and T-cell clonality for diagnosis and monitoring of B- and T-cell neoplasms. [PDF]

FEBS Open Bio
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Albitar A, Agersborg S, Charifa A, Phull P, Biran N, Vesole D, Parmar H, Pecora A, Ip A, Goy A, Siegel D, Albitar M.   +11 more
europepmc   +2 more sources

Clinicohaematological Study of Leukaemias at a Tertiary Care Centre, Vindhya Region of India: A Cross-sectional Study [PDF]

National Journal of Laboratory Medicine, 2023
Introduction: Leukaemia is characterised by widespread proliferation of leucocytes and their precursors in the body tissues and is usually associated with qualitative and quantitative changes in circulating white blood cells.
Lekha Ramchandani, Jagannath Jatav, Di ya Bajaj, RK Vineeth Kumar   +3 more
doaj   +1 more source

Prognostic Factors and Survival Outcomes by Disease Subtypes in a Cohort of Iranian Patients with acute leukemia [PDF]

Reviews in Clinical Medicine, 2023
Introduction: Studying the survival factors of leukemia patients can lead to a reduction in healthcare costs. This study aimed to evaluate the survival rate and potential predictive factors in leukemia patients in northeast Iran.Methods: Baseline ...
Sahar Ravanshad, Zahra Fahimian, Parsa Shoghi, Ali Moradi, Valareza Alizadeh, Negar Javdan, Hassan Mehrad-Majd   +6 more
doaj   +1 more source

Case Report: Mature Plasmacytoid Dendritic Cell Proliferation Associated With a Lymphoid Neoplasm

Frontiers in Oncology, 2022
Mature plasmacytoid dendritic cell proliferations (MPDCPs) are clonal, non-malignant pDC proliferations that have been reported to occur in association with myeloid neoplasms such as CMML, AML (pDC-AML), and, rarely, MDS or MPNs. Here we report the first
Fei Fei, Michaela Liedtke, Oscar Silva
doaj   +1 more source

Changing Management of Hematological Malignancies With COVID-19: Statement and Recommendations of the Lebanese Society of Hematology and Blood Transfusion

Frontiers in Oncology, 2021
COVID-19 caused by SARS-Cov-2 is a devastating infection in patients with hematological malignancies. In 2018, the Lebanese Society of Hematology and Blood Transfusion (LSHBT) updated the guidelines for the management of hematological malignancies in ...
Ahmad Ibrahim, Ahmad Ibrahim, Ahmad Ibrahim, Ahmad Ibrahim, Peter Noun, Peter Noun, Charbel Khalil, Charbel Khalil, Ali Taher, Ali Taher, Ali Taher   +10 more
doaj   +1 more source

Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk

Nature Communications, 2022
Follicular lymphoma can transform to a more aggressive histology. Here, the authors use bulk and single cell analysis to create a 26 marker panel which could be used to profile FL samples and predict the risk of transformation using flow cytometry.
Xuehai Wang, Michael Nissen, Deanne Gracias, Manabu Kusakabe, Guillermo Simkin, Aixiang Jiang, Gerben Duns, Clementine Sarkozy, Laura Hilton, Elizabeth A. Chavez, Gabriela C. Segat, Rachel Wong, Jubin Kim, Tomohiro Aoki, Rashedul Islam, Christina May, Stacy Hung, Kate Tyshchenko, Ryan R. Brinkman, Martin Hirst, Aly Karsan, Ciara Freeman, Laurie H. Sehn, Ryan D. Morin, Andrew J. Roth, Kerry J. Savage, Jeffrey W. Craig, Sohrab P. Shah, Christian Steidl, David W. Scott, Andrew P. Weng   +30 more
doaj   +1 more source

Synergistic regulation of Notch signaling by different O-glycans promotes hematopoiesis

Frontiers in Immunology, 2023
Glycosylation of Notch receptors by O-fucose glycans regulates Notch ligand binding and Notch signaling during hematopoiesis. However, roles in hematopoiesis for other O-glycans that modify Notch receptors have not been determined.
Ankit Tanwar, Pamela Stanley
doaj   +1 more source

Spectrum of immunophenotypic aberrancies in acute leukemia along with their correlation with adverse hematological parameters

Indian Journal of Health Sciences and Biomedical Research KLEU, 2022
BACKGROUND: The identification of aberrant phenotypes in acute leukemia is crucial for treatment monitoring and minimal residual disease analysis.
Sana Ahuja, Avneesh Malviya
doaj   +1 more source