Results 31 to 40 of about 258,275 (268)

Tissue Tregs and Maintenance of Tissue Homeostasis

Frontiers in Cell and Developmental Biology, 2021
Regulatory T cells (Tregs) specifically expressing Forkhead box P3 (Foxp3) play roles in suppressing the immune response and maintaining immune homeostasis.
Qing Shao, Qing Shao, Qing Shao, Qing Shao, Jian Gu, Jian Gu, Jian Gu, Jian Gu, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Xiangyu Li, Xiangyu Li, Xiangyu Li, Xiangyu Li, Zhenhua Deng, Zhenhua Deng, Zhenhua Deng, Zhenhua Deng, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +27 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Formation of immune structures in small intestine of Muscovy ducks (Cairina moschata)

Theoretical and Applied Veterinary Medicine, 2020
Of particular importance in our time is the detailed study of morphology, physiology and biochemistry, the digestive system of new poultry crosses, which is the biological basis for the development of complete feeding and improving the productive ...
V. V. Logvinova, A. V. Oliyar, M. A. Lieshchova   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Establishment and function of tissue-resident innate lymphoid cells in the skin

Protein & Cell, 2017
Innate lymphoid cells (ILCs) are a newly classified family of immune cells of the lymphoid lineage. While they could be found in both lymphoid organs and non-lymphoid tissues, ILCs are preferentially enriched in barrier tissues such as the skin ...
Jie Yang, Luming Zhao, Ming Xu, Na Xiong
doaj   +1 more source

Morphology of the digestive canal organs and their immune formations in the mulard ducks

Ukrainian Journal of Veterinary Sciences, 2022
It is known that in the immune formations of the digestive canal of birds, which belong to the peripheral organs of hematopoiesis and lymphopoiesis, differentiation of T- and B-lymphocytes occurs under the influence of antigens that cause the development
Nadiia Dyshliuk, Svitlana Huralska, Oksana Mamai   +2 more
doaj   +1 more source