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Lymphokine activated killer cells
Blut, 1989Various subpopulations of human leukocytes may be induced by lymphokines to exert cytotoxic activity. In man major histocompatibility complex non-restricted tumor cell lysis by interleukin-2 (IL-2) induced peripheral blood lymphocytes is attributed mainly to natural killer cells.
A, Lindemann +3 more
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Lymphokine-activated killer cell activity after cryopreservation
Journal of Immunological Methods, 1989The effect of cryopreservation on the cytotoxic activity of lymphokine-activated killer (LAK) cells was studied. LAK cells were generated by incubating peripheral blood lymphocytes for 3-5 days with recombinant interleukin-2 (rIL-2) and then cryopreserved using a programmed freezer. Cytotoxicity was determined in a 51Cr release assay.
I G, Schmidt-Wolf +4 more
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Cellular Immunology, 1989
The coculture of rat bone marrow cells with recombinant interleukin-2 induced the generation of cells mediating natural killer (NK) activity and subsequent lymphokine-activated killer (LAK) activity depending upon the dose of IL-2 and time of culture. NK activity was detected as early as 4 to 5 days after the addition of IL-2 and could be evoked with ...
M, Sarneva +4 more
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The coculture of rat bone marrow cells with recombinant interleukin-2 induced the generation of cells mediating natural killer (NK) activity and subsequent lymphokine-activated killer (LAK) activity depending upon the dose of IL-2 and time of culture. NK activity was detected as early as 4 to 5 days after the addition of IL-2 and could be evoked with ...
M, Sarneva +4 more
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Natural killer cells. Lymphokine-activated killers
2008Tumors can escape from adaptive immune reactions mediated by cytotoxic T-lymphocytes via down-regulation or complete loss of major histocompatibility class I molecules. Some, and perhaps most, of tumors also seem to lack tumor-specific antigens that may be recognized by adaptive immunity.
Irina Zh. Shubina +4 more
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Lymphokine-activated killer cells, natural killer cells and cytokines
Current Opinion in Immunology, 1991In the past year, natural killer cells have been the subject of much active investigation. The analysis of the effect of cytokines on the generation, proliferation and function of natural killer cells, and the definition of the lymphokines that they produce, have been particularly important areas of research in view of their possible application in ...
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Lymphokine-Activated Killer Cell Activity in Lung Cancer
Chest, 1991This study evaluates local pulmonary immune effector cell lytic activity. Purified lymphocyte populations were isolated from BALF obtained from 18 patients with bronchogenic carcinoma, six patients with lung disorders other than cancer, and ten normal control volunteers matched for age and smoking history. These cells were evaluated for NK and LAK cell
A, LeFever, A, Funahashi
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Apheresis techniques in lymphokine‐activated killer cell production
Journal of Clinical Apheresis, 1988AbstractAdoptive transfer of autologous lymphokine‐activated killer cells (LAK) in conjunction with recombinant interleu‐kin‐2 (rIL‐2) has been reported to produce significant regression in metastatic disease in patients with advanced cancer. In an effort to confirm the results reported by the Surgery Branch of the National Cancer Institute, the same ...
I, Sniecinski +3 more
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Generation of lymphokine-activated killer cell activity from human thymocytes.
Journal of Immunology, 1987We have generated lymphokine-activated killer (LAK) cells from human thymocytes in order to assess the relationship between LAK cells and T cells. Fresh thymocytes lack natural cytotoxic activity, and cytotoxicity cannot be stimulated by short term (1 hr)
F. Ramsdell, S. Golub
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Heterogeneity of the lymphokine-activated killer cell phenotype
Cellular Immunology, 1991Lymphokine-activated killer cells (LAK) are functionally defined by their ability to mediate the MHC-unrestricted lysis of a range of tumor targets, while sparing normal cells. They can also lyse TNP-modified normal syngeneic lymphoblasts. We show here that lysis of TNP-modified targets is mediated by CD8+ LAK in a self-MHC-restricted manner, whereas ...
B S, Chadwick, R G, Miller
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Phenotypic characterization of murine lymphokine-activated killer cells
Cellular Immunology, 1986Short-term culture of murine lymphocytes in interleukin 2 (IL-2), in the absence of any priming antigen, has been shown to result in the differentiation of an activated killer cell population capable of potent cytotoxic activity against tumor cells. The progenitor and lineage of these lymphokine activated killer cells (LAK) remains controversial.
L B, Owen-Schaub +2 more
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