Results 51 to 60 of about 15,433 (212)

Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels

Small, Volume 20, Issue 46, November 14, 2024.
This study investigates the potential of high‐throughput droplet microfluidics for microencapsulation of human macrophages in hollow, sacrificial tyramine‐conjugated dextran microgels to facilitate osteoclast formation. Intriguingly, osteoclast formation within these 3D microenvironments is occurring at a significantly higher level compared to the ...
Johanna F.A. Husch, Nuno Araújo‐Gomes, Niels G.A. Willemen, Carla Cofiño‐Fabrés, Nils van Creij, Robert Passier, Jeroen Leijten, Jeroen J. J. P. van den Beucken   +7 more
wiley   +1 more source

A preliminary study on IL4 levels in extrinsic atopic asthmatic children

The Turkish Journal of Pediatrics, 1994
Interleukin 4, (IL4) known as a lymphokine secreted by type II helper T-cells, is thought to regulate IgG and IgE secretions. Therefore, elevated IL4 levels are expected in atopic allergic disease and parasitoses.
N Akçakaya, V Sözer, H Cokuğraş, Y Söylemez, G Yilmaz   +4 more
doaj  

CD8⁺, HLA-unrestricted, cytotoxic T-lymphocyte line against malignant melanoma

Journal of Translational Medicine, 2005
A CD8+ cytotoxic T lymphocyte (CTL) line was derived from the peripheral blood mononuclear cells of a patient with primary melanoma. The CD8+ CTL line specifically lysed the autologous primary melanoma cells and not the natural killer cell-sensitive K562
Guerry DuPont, Caputo Laura, Somasundaram Rajasekharan, Herlyn Dorothee   +3 more
doaj   +1 more source

Targeting CD25+ lymphoma cells with the antibody–drug conjugate camidanlumab tesirine as a single agent or in combination with targeted agents

British Journal of Haematology, Volume 205, Issue 5, Page 1873-1882, November 2024.
Camidanlumab tesirine is a CD25‐specific antibody‐drug conjugate employing SG3199, a highly cytotoxic DNA minor groove cross‐linking pyrrolobenzodiazepine dimer, with cytotoxic activity in lymphoma cells. The addition of other drugs targeting additional pathways can synergize with camidanlumab tesirine. Created with Biorende.
Filippo Spriano, Chiara Tarantelli, Luciano Cascione, Eugenio Gaudio, Gaetanina Golino, Lorenzo Scalise, Maria Teresa Cacciapuoti, Emanuele Zucca, Anastasios Stathis, Patrick H. Van Berkel, Giorgio Inghirami, Francesca Zammarchi, Francesco Bertoni   +12 more
wiley   +1 more source

Molecular and cellular basis of hepatic fibrogenesis in experimental schistosomiasis mansoni infection

Memorias do Instituto Oswaldo Cruz, 1992
Morbidity in schistosomiasis mansoni occurs primaryly as a result of the complications of hepatic fibrosis. Yet, the pathogenesis of schistosomal hepatic fibrosis is poorly understood. The fact that hepatic egg granuloma is the hallmark of this infection
David J. Wyler
doaj   +1 more source

Dynamic changes in macrophage polarization during the resolution phase of periodontal disease

Immunity, Inflammation and Disease, Volume 12, Issue 10, October 2024.
This is the first translational studies to longitudinally assess the M/M2 MΦ profiles before and after therapy in periodontitis subjects and can serve as the first step in examining current treatment strategies to include investigations on the role of macrophage immune mediated regulatory networks governing periodontal disease pathogenesis.
Juhi R. Uttamani, Varun Kulkarni, Araceli Valverde, Raza Ali Naqvi, Thomas Van Dyke, Salvador Nares, Afsar R. Naqvi   +6 more
wiley   +1 more source

A systematic review of case–control studies of cytokines in blister fluid and skin tissue of patients with Stevens Johnson syndrome and toxic epidermal necrolysis

Australasian Journal of Dermatology, Volume 65, Issue 6, Page 491-504, September 2024.
Abstract Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions characterised by keratinocyte apoptosis, necroptosis and epidermal detachment. Several cytokines and cytotoxic proteins have been shown to be elevated in the blood and skin of SJS/TEN sufferers and biologics such as intravenous immune ...
Thomas Jonathan Stewart, Joshua Farrell, John Walter Frew   +2 more
wiley   +1 more source

A hypothesis on treatment strategy of severe multicentric Castleman disease with continuous renal replacement therapy

Journal of Cellular and Molecular Medicine, Volume 28, Issue 17, September 2024.
Abstract Castleman disease (CD) is a rare lymphoproliferative disorder, with non‐specific clinical manifestations, often delayed diagnosis and treatment, which pose a significant challenge in the present times. Patients diagnosed with this disease have poor prognosis due to the limited treatment options.
Cătălin Constantinescu, David Kegyes, Bogdan Tigu, Vlad Moisoiu, Olga Grăjdieru, Andrea Szekely, Evangelos Terpos, Ciprian Tomuleasa   +7 more
wiley   +1 more source

Natural killer cells in cancer immunotherapy

MedComm, Volume 5, Issue 7, July 2024.
NK cells have cytotoxic functions against tumor cells especially through NKG2D receptor. This article reviews the mechanisms how tumors escape NK‐mediated killing and therapeutic strategies with NK cells and especially MICA/B–NKG2D axis. Finally, the recent innovative CAR‐NK/NKG2D CAR‐T and MICA/B vaccines in tumor were summarized.
DanRu Wang, LingYun Dou, LiHao Sui, Yiquan Xue, Sheng Xu   +4 more
wiley   +1 more source

The low efficiency of dendritic cells and macrophages from mice susceptible to Paracoccidioides brasiliensis in inducing a Th1 response

Brazilian Journal of Medical and Biological Research, 2001
In the present study we evaluated T cell proliferation and Th lymphokine patterns in response to gp43 from Paracoccidioides brasiliensis presented by isolated dendritic cells from susceptible and resistant mice.
S.R. Almeida, J.D. Lopes
doaj   +1 more source