Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response
, 1986 The control of immunoglobulin class switching appears to involve T cell-derived lymphokines. Such lymphokines have been shown to affect isotype expression in polyclonally activated B cells.
Muller, W.; id_orcid +2 more
core +10 more sources
Interferon as a macrophage activating factor. I. Enhancement of cytotoxicity by fresh and matured human monocytes in the absence of other soluble signals [PDF]
, 1983 The cytolytic activity ofhuman peripheral blood monocytes in vitro against K-562 human leukaemic target cells was stimulated by human fibroblast (fi-) and leucocyte (a-) interferon (IFN). Stimulation was by up to several times the corresponding control
Virelizier, JL, Dean, RT
core +7 more sources
Comparison of Thrombocytopenia and Splenomegaly in Locally Advanced Rectal Cancer Patients Receiving Total Neoadjuvant Therapy With and Without Immunotherapy. [PDF]
Cancer MedABSTRACT Background Thrombocytopenia is a common toxicity of oxaliplatin‐based chemotherapy and may be linked to hepatic sinusoidal obstruction and splenic enlargement. In the TORCH trial, adding PD‐1 blockade to an oxaliplatin‐containing total neoadjuvant therapy (TNT) regimen improved tumor response in patients with locally advanced rectal cancer ...
Li S +10 more
europepmc +2 more sources
Reconceptualizing Aplastic Anemia-Seed, Worm, Soil. [PDF]
J Clin Lab AnalAplastic anemia (AA) encompasses a group of hematological syndromes often misdiagnosed, resulting in a decrease in the overall blood cell count and representing a form of bone marrow failure. We reinterpret AA based on the “seed, worm, and soil” doctrine.
Xu X, Wang Z, Hu J, Liu C, Fu R.
europepmc +2 more sources
Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection. [PDF]
Eur J ImmunolSARS‐CoV‐2 vaccination in rheumatoid arthritis leads to the development of CD4+ and CD8+ spike‐specific T cell memory, regardless of immunosuppressive therapies, and the number of vaccine injections. CD4−CD8− double‐negative (DN) T cells responded to SARS‐CoV‐2 peptide epitopes and differentiated into CD8+ cytotoxic T cells after stimulation ...
Song J +5 more
europepmc +2 more sources
Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Mediators InflammAutoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H +4 more
europepmc +2 more sources
MECHANISMS OF VIRUS-INDUCED IMMUNOSUPPRESSION AND MODULATION OF VIRUS MULTIPLICATION BY LYMPHOKINES.
, 1985 MECHANISMS OF VIRUS-INDUCED IMMUNOSUPPRESSION AND MODULATION OF VIRUS MULTIPLICATION BY ...
NIWAT. MANEEKARN (7981184)
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Journal of Veterinary Research, 2018 Introduction:Coxiella (C.) burnetii, the aetiological agent of Q fever, is able to modulate the macrophage/T-lymphocyte axis in an infected organism and impair synthesis of monokines and lymphokines.
Małaczewska Joanna +6 more
doaj +1 more source
Cytokines as determinants of disease and disease interactions
Brazilian Journal of Medical and Biological Research, 1998 The immune response to pathogens results in both host resistance and immunopathology. Cytokines and in particular those lymphokines produced by Th1 and Th2 cells play a key role in determining the balance between these two immunologic outcomes.
A. Sher +6 more
doaj +1 more source
BBA Advances, 2021 We have previously demonstrated that weekly treatment of female prediabetic NOD mice with a low dose of the histone deacetylase inhibitor Trichostatin A (TSA) bestowed long-lasting, irreversible protection against autoimmune diabetes. Herein we show that
Arathi Jayaraman +2 more
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