Results 71 to 80 of about 672,004 (247)

Primary diffuse large B-cell lymphoma of the CNS, with a Lymphomatosis cerebri pattern [PDF]

, 2021
Balamurugan Thirunavukkarasu, Kirti Gupta, Ritu Shree, Anuj Prabhakar, Aastha Takkar Kapila, Vivek Lal, Bishan Dass Radotra   +6 more
openalex   +1 more source

Integrating Single‐Cell Transcriptome‐Wide Mendelian Randomization and Differentially Expressed Gene Analyses to Prioritize Dynamic Immune‐Related Drug Targets for Cancers

Advanced Science, EarlyView.
Inspired by evidence triangulation, a new sensitivity method called MR‐DEG is developed, which uses the differentially expressed gene (DEG) results as additional evidence to minimize pleiotropic effects and strengthen Mendelian randomization (MR) causal estimates. Using dynamic single‐cell expression quantitative trait loci (eQTLs) as an example, it is
Jie Zheng, Qian Yang, Haoyu Liu, Huiling Zhao, Shuangyuan Wang, Yi Liu, Xueyan Wu, Yilan Ding, Hui Ying, Youqiu Ye, Xi Huang, Lei Ye, Ruizhi Zheng, Hong Lin, Mian Li, Tiange Wang, Zhiyun Zhao, Min Xu, Yi Duan, Hao Guo, Zhongshang Yuan, Philip Haycock, George Davey Smith, Richard M Martin, Guang Ning, Fang Hu, Weiqing Wang, Tom R. Gaunt, Jieli Lu, Yufang Bi   +29 more
wiley   +1 more source

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Assessment of the Hematopoietic Cell Transplantation Comorbidity Index in Non-Hodgkin Lymphoma Patients Receiving Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation [PDF]

, 2009
Seth M. Pollack, Seth M. Steinberg, Jeanne Odom, Robert M. Dean, Daniel H. Fowler, Michael Bishop   +5 more
openalex   +1 more source

Autologous peripheral blood stem cell mobilization and collection in patients with lymphoma and multiple myeloma [PDF]

, 2022
Ahmad Alsaeed, Mona J. Najib, Sameer M. Al Amoudi, Ihab El‐Hemaidi, Ahmed Absi, Majed D. Al Ahmadi, Saleem Eldadah, Walaa Rajkhan, Manar Khalil, Mohammed Almohammadi   +9 more
openalex   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, EarlyView.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

The CDK9 inhibitor enitociclib overcomes resistance to BTK inhibition and CAR-T therapy in mantle cell lymphoma

Biomarker Research
Inhibitors of Bruton’s tyrosine kinase (BTKi) and chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 are paradigm-shifting advances in treating patients with aggressive mantle cell lymphoma (MCL).
Vivian Jiang, William Lee, Tianci Zhang, Alexa Jordan, Fangfang Yan, Qingsong Cai, Joseph McIntosh, Jovanny Vargas, Yang Liu, Michael Wang   +9 more
doaj   +1 more source

Prognostic Value of Bone Marrow Tracer Uptake Pattern in Baseline PET Scans in Hodgkin Lymphoma: Results from an International Collaborative Study [PDF]

, 2017
C. Zwarthoed, Tarec Christoffer El‐Galaly, Maria Elisa Canepari, M.J. Ouvrier, Julien Viotti, Marc Ettaiche, Simonetta Viviani, Luigi Rigacci, Livio Trentin, Chiara Rusconi, Stefano Luminari, Maria Cantonetti, Silvia Bolis, Anna Borra, Jacques Darcourt, Flavia Salvi, Edyta Subocz, J. Tajer, Waldemar Kulikowski, Bogdan Małkowski, Jan Maciej Zaucha, Andrea Gallamini   +21 more
openalex   +1 more source

Clinical characteristics and outcomes of patients with diffuse large B cell lymphoma treated with R-CHOP-like or CHOP-like regimens: an 8-year experience from a single center [PDF]

, 2020
Haobo Huang, Liping Fan, Danhui Fu, Qiuyan Lin, Jianzhen Shen   +4 more
openalex   +1 more source