Results 201 to 210 of about 510,795 (264)

Expanding the Genetic Code with Lysine Aminoacylation. [PDF]

J Am Chem Soc
Li X, Gan Q, Fan C.
europepmc   +1 more source

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Novel L-lysine α-oxidase from marine streptomyces: production, optimization and potent antibacterial activity against drug-resistant pathogens. [PDF]

Microb Cell Fact
Abdelraof M, Hassabo AA, Darwich D, Abdel-Monsef MM.   +3 more
europepmc   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics. [PDF]

Clin Transl Med
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S.   +5 more
europepmc   +1 more source

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis. [PDF]

Int J Mol Med
Fan Z, Fu Q, Sun T, Zhong Y, Ma Y, Jian J, Yuan S, Li S, Xu X.   +8 more
europepmc   +1 more source

Boron-Rich Biologics Enabled by Reactive Organic Carboranes. [PDF]

JACS Au
Jenko A, Barbič U, Renko A, Hsu CP, Jemc D, Makuc Š, Jamnik L, Marolt G, Župunski V, Loas A, Pentelute BL, Gazvoda M.   +11 more
europepmc   +1 more source

Metabolic Reprogramming-Driven Lactylation: Emerging Mechanisms Linking DNA Damage Repair and Chemoresistance in Cancer. [PDF]

Cells
Wang L, Zhong S, Zhao J, Liu L, Li C.
europepmc   +1 more source

Lysine acetylome profiling reveals a dual regulatory role in carbon flux redirection and RNA degradation inhibition in <i>Mycobacterium smegmatis</i>. [PDF]

Front Microbiol
Sun M, Zhao Q, Zhou C, Liu C, Yang B, Bu J, Li R, Bian J, Niu X, Hu J, Liu B, Ge S.   +11 more
europepmc   +1 more source