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Acylated peptide enrichment utilizing lysine deacylases for lysine acylomics

Biochemical and Biophysical Research Communications, 2021
Reversible acylation of lysine ε-amino groups, e.g., acetylation, succinylation, maronylation, and myristoylation, is involved in basic physiological processes such as metabolism, cell signaling and aging. In this study, we developed a novel enrichment method for acylated peptides without the use of antibodies, in which endogenously acylated peptides ...
Kazuya Tsumagari, Yasushi Ishihama
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Advanced Delivery Systems Based on Lysine or Lysine Polymers

Molecular Pharmaceutics, 2021
Polylysine and materials that integrate lysine form promising drug delivery platforms. As a cationic macromolecule, a polylysine polymer electrostatically interacts with cells and is efficiently internalized, thereby enabling intracellular delivery. Although polylysine is intrinsically pH-responsive, the conjugation with different functional groups ...
Saeed Manouchehri   +3 more
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Crystalline lysine decarboxylase

Biochemical and Biophysical Research Communications, 1969
Lysine decarboxylase (L-lysine carboxy-lyase, E.C. 4.1.1.18) was discovered and partially purified from Bacterium cadaveris and Escherichia coli by Gale and his coworker (Gale and Epps, 1944; Gale, 1945). Despite the wide-spread use of this enzyme for the manometric determination of L-lysine, it has not been enzymologically well-characterized.
K, Soda, M, Moriguchi
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Photo-lysine captures proteins that bind lysine post-translational modifications

Nature Chemical Biology, 2015
Post-translational modifications (PTMs) have key roles in regulating protein-protein interactions in living cells. However, it remains a challenge to identify these PTM-mediated interactions. Here we develop a new lysine-based photo-reactive amino acid, termed photo-lysine.
LI, X, BAO, X, Fung, EYM, Li, X, YANG, T
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Lysine-rich proteins in high-lysine Hordeum vulgare grain

Phytochemistry, 1973
Abstract The salt-soluble proteins in barley grain selected for high-lysine content (Hiproly, CI 7115 and the mutants 29 and 86) and of a control (Carlsberg II) with normal lysine content, contain identical major proteins as determined by MW and electrophoretic mobility.
J. Ingversen, B. Køie
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Lysine Infusion in Cystinuria: Theoretical Renal Thresholds for Lysine

Clinical Science, 1973
1. The renal handling of lysine was studied during the intravenous infusion of a lysine load given in such a way that the plasma lysine concentration was constantly increasing. Theoretical renal thresholds, and maximum rates of renal tubular reabsorption of lysine, have been determined in three normal adults, five homozygous cystinuric patients, and ...
F T, Lester, D C, Cusworth
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Failure of Lysine?

Archives of Dermatology, 1985
To the Editor.— In the JanuaryArchives, DiGiovanna and Blank 1 reported failure of lysine in frequently recurrent herpes simplex infection. Caution is urged in the interpretation of their results. The L-isomer allosterically inhibits herpes in vitro, 2,3 while the D-isomer is biologically inactive.
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L-Lysine Fermentation

Recent Patents on Biotechnology, 2007
Amino acids are the basic bioelements of proteins, which are the most important macromolecules for the functions of humans and animals. Out of the 20 L-amino acids, ecumenically found in most of living organisms, L-lysine is one of the 9 amino acids which are essential for human and animal nutrition.
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Lysine kinetics at graded lysine intakes in young men

The American Journal of Clinical Nutrition, 1986
Healthy young men participated in a study designed to explore the effects of decreasing dietary lysine content on plasma amino acid concentrations and lysine kinetics, studied with L-[1-13C]lysine as tracer. Diets provided adequate energy and the equivalent (N X 6.25) of 0.8 g protein kg-1.day-1 as a synthetic L-amino acid mixture simulating egg ...
C N, Meredith   +4 more
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N-Substituted Lysines as Sources of Lysine in Nutrition

1978
Twenty seven alpha-N- and epsilon-N-substituted derivatives of lysine belonging to eight different classes: (1) natural dipeptides, (2) alpha-N-acyl-, (3)epsilon-N-acyl-, (4)epsilon-N-(alpha-amino acyl)-, (5)epsilon-N-(omega-amino acyl)-, (6)alpha-N-epsilon-N-di-amino acyl-, (7)epsilon-N-acylglycyl- and (8)Schiff's bases were synthesized. The "in vitro"
P A, Finot   +3 more
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