Results 251 to 260 of about 656,192 (343)

Self‐Assembling Peptide Hydrogels Support Stromal Vascular Fraction Viability to Promote In Vivo Nerve Regeneration

Advanced Healthcare Materials, EarlyView.
Stromal vascular fraction (SVF) may enhance nerve repair, especially when delivered in a self‐assembling peptide hydrogel (SAPH). In vitro, softer SAPH increased neuronal explant outgrowth and supported greater SVF viability and proliferation. In a rat sciatic defect, SVF in an optimized SAPH produced motor and sensory recovery equivalent to autograft ...
Liam A. McMorrow, Steffan Llewellyn, Jared McSweeney, Alessandro Faroni, Aline F. Miller, Alberto Saiani, Adam J. Reid   +6 more
wiley   +1 more source

Supplementary Materials for Adaptive mutations at lysine residues of PRRSV nsp12 enable evasion of host proteasomal and selective autophagic degradation

Chen Yong-jie, Chen Zishen, Huang Ling, Zeng, Siyong, Huang Baoying, Guo ChunHe   +5 more
openalex   +1 more source

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Functional property enhancement of walnut flower melanin by lysine modification: Structural characterization, stability, and bioactivity studies. [PDF]

Food Chem X
Liang W, Li B, Zhou Q, Di J.
europepmc   +1 more source

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Cell Metabolism, 2014
Minjia Tan, Chao Peng, K. A. Anderson, Peter Chhoy, Zhongyu Xie, Lunzhi Dai, Jeongsoon Park, Yue Chen, He Huang, Yi Zhang, J. Ro, G. R. Wagner, Michelle F. Green, A. Madsen, J. Schmiesing, Brett S. Peterson, Guofeng Xu, O. Ilkayeva, M. Muehlbauer, T. Braulke, C. Mühlhausen, Donald S. Backos, C. Olsen, P. McGuire, S. Pletcher, D. Lombard, M. Hirschey, Yingming Zhao   +27 more
semanticscholar   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Lysine succinylation as a metabolic switch in cardiovascular diseases: Mechanistic insights and therapeutic perspectives. [PDF]

Redox Biol
Mu F, Zhang H, Gong R, Lin R, Zhao M, Tao X, Shang L, Xi M, Zhao J, Wang J.   +9 more
europepmc   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Machine learning-driven prediction of substrates for enzymes introducing or removing protein post-translational modifications. [PDF]

Commun Chem
Ridgeway NH, Chopra A, Lukinović V, Feldman M, Charih F, Levy D, Green JR, Biggar KK.   +7 more
europepmc   +1 more source

How the lysine riboswitch folds

, 2016
Kaley McCluskey
openalex   +1 more source