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First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Engineering Pseudomonas taiwanensis VLB120 for regio- and stereospecific hydroxylation of l-lysine fueled by the Weimberg pathway

Philipp Nerke, Julian Handke, Georg Hubmann, Stephan Lütz   +3 more
openalex   +1 more source

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Lysine kinetics at graded lysine intakes in young men

American Journal of Clinical Nutrition, 1986
Healthy young men participated in a study designed to explore the effects of decreasing dietary lysine content on plasma amino acid concentrations and lysine kinetics, studied with L-[1-13C]lysine as tracer. Diets provided adequate energy and the equivalent (N X 6.25) of 0.8 g protein kg-1.day-1 as a synthetic L-amino acid mixture simulating egg ...
Dm Bier, V R Young, D M Bier
exaly   +3 more sources

Formation of thymine-lysine and cytosine-lysine adducts in DNA-lysine photoconjugate

Journal of Photochemistry and Photobiology B: Biology, 1995
Lysine was covalently conjugated to calf thymus DNA by irradiation with UV light (wavelength, 253.7 nm). The results showed monofunctional covalent photobinding of lysine molecules with bases in DNA. Only the epsilon-amino group of lysine participated in the photoconjugation reaction. Thymine and cytosine were modified by 60% and 25% respectively.
N, Islam, R, Ali
openaire   +2 more sources

Antibacterial lysine analogs that target lysine riboswitches

Nature Chemical Biology, 2006
Lysine riboswitches are bacterial RNA structures that sense the concentration of lysine and regulate the expression of lysine biosynthesis and transport genes. Members of this riboswitch class are found in the 5' untranslated region of messenger RNAs, where they form highly selective receptors for lysine.
Kenneth F, Blount, Joy Xin, Wang, Jinsoo, Lim, Narasimhan, Sudarsan, Ronald R, Breaker   +4 more
openaire   +2 more sources

Lysine−Bisglycidol Conjugates as Novel Lysine Cationic Surfactants

Langmuir, 2009
The synthesis of a novel class of lysine-based cationic amphiphilic derivatives of the type N(epsilon),N(epsilon)'-bis(n-acyloxypropyl)-l-lysine methyl ester salts combining several hydroxyl functions and aliphatic chains of 12 or 14 carbon atoms is described. The compounds have one, two, three, and four alkyl chains.
Pinazo Gassol, Aurora, Angelet, Marta, Pons Pons, Ramon, Lozano, Marina, Infante, María Rosa, Pérez, Lourdes   +5 more
openaire   +3 more sources

Advanced Delivery Systems Based on Lysine or Lysine Polymers

Molecular Pharmaceutics, 2021
Polylysine and materials that integrate lysine form promising drug delivery platforms. As a cationic macromolecule, a polylysine polymer electrostatically interacts with cells and is efficiently internalized, thereby enabling intracellular delivery. Although polylysine is intrinsically pH-responsive, the conjugation with different functional groups ...
Saeed Manouchehri, Payam Zarrintaj, Mohammad Reza Saeb, Joshua D. Ramsey   +3 more
openaire   +2 more sources

Trifluoroacetyl Lysine as a Bromodomain Binding Mimic of Lysine Acetylation

ACS Chemical Biology, 2022
Genetic code expansion has proven invaluable to the elucidation of functions of defined protein modifications through the site-specific incorporation of noncanonical amino acids. The use of nonhydrolyzable derivatives of post-translational modifications can greatly increase site stoichiometry and half-life.
Gregory M. Miller, E. Megan Flynn, Jeffrey Tom, Aimin Song, Andrea G. Cochran   +4 more
openaire   +2 more sources

Failure of Lysine?

Archives of Dermatology, 1985
To the Editor.— In the JanuaryArchives, DiGiovanna and Blank 1 reported failure of lysine in frequently recurrent herpes simplex infection. Caution is urged in the interpretation of their results. The L-isomer allosterically inhibits herpes in vitro, 2,3 while the D-isomer is biologically inactive.
openaire   +2 more sources

N-Substituted Lysines as Sources of Lysine in Nutrition

1978
Twenty seven alpha-N- and epsilon-N-substituted derivatives of lysine belonging to eight different classes: (1) natural dipeptides, (2) alpha-N-acyl-, (3)epsilon-N-acyl-, (4)epsilon-N-(alpha-amino acyl)-, (5)epsilon-N-(omega-amino acyl)-, (6)alpha-N-epsilon-N-di-amino acyl-, (7)epsilon-N-acylglycyl- and (8)Schiff's bases were synthesized. The "in vitro"
P A, Finot, F, Mottu, E, Bujard, J, Mauron   +3 more
openaire   +2 more sources