Results 301 to 310 of about 933,247 (382)

Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions. [PDF]

J Med Chem
Friedrich F, Schiedel M, Swyter S, Zhang L, Sippl W, Schutkowski M, Einsle O, Jung M.   +7 more
europepmc   +1 more source

Radioactive lysine in protein metabolism studies. Synthesis and utilization of plasma proteins

, 1950
L. L. Miller, William F. Bale, Charles L. Yuile, Raymond E. Masters, Garson H. Tishkoff, G. H. Whipple   +5 more
openalex   +2 more sources

Choroid Plexus Fibroblast–ILC2 Niche Promotes Adult Hippocampal Neurogenesis after Traumatic Brain Injury

Advanced Science, EarlyView.
This study investigates the role of group 2 innate lymphoid cells (ILC2) in the choroid plexus (ChP) following traumatic brain injury (TBI). ILC2 accumulation alleviates immune infiltration, preserves hippocampal integrity, and improves sensory‐motor and memory functions.
Shiqi Gao, Xiaoming Guo, Sixuan Tian, Huaping Huang, Caidi Ying, Junjie Wang, Jiahao Zhang, Jun Lin, Anwen Shao, Jingyu Wang, Yuan Hong   +10 more
wiley   +1 more source

Investigation and design of the dual specificity of the PRDM9 protein lysine methyltransferase. [PDF]

Commun Biol
Graf D, Schnee P, Pleiss J, Weirich S, Jeltsch A.   +4 more
europepmc   +1 more source

Effect of D-, L-, and DL-lysine on the growth of young rats

, 1958
吉川 春寿, 小松 節子
openalex   +2 more sources

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

A Poly-Lysine-Based RBD Mucosal Vaccine Induces Potent Antibody Responses in Mice. [PDF]

Vaccines (Basel)
Xu H, Wang H, Sun P, Wang T, Zhang B, Hou X, Wu J, Liu B.   +7 more
europepmc   +1 more source

Comprehensive Characterization of Bihormonal Cells and Endocrine Cell Lineages in Mammalian Pancreatic Islets

Advanced Science, EarlyView.
This study integrates dual‐reporter genetics, imaging flow cytometry, and single‐cell sequencing to characterize rare bihormonal cells in mouse and human pancreatic islets. Gcg⁺Ins⁺ cells resemble α‐cells rather than transitional states. Cross‐species gene network analysis refines islet cell taxonomy and reveals human‐specific δ‐cell subtypes ...
Xin‐Xin Yu, Peng Peng, Yi‐Ning Wang, Mao‐Yang He, Shuang He, Chen‐Tao Jin, Liu Yang, Xi Wang, Jia‐Xi Zheng, Jie Gao, Cheng‐Ran Xu   +10 more
wiley   +1 more source

Comprehensive Ubiquitome Analysis of <i>Nicotiana benthamiana</i> Leaves Infected with Tomato Brown Rugose Fruit Virus. [PDF]

Biology (Basel)
Yang J, Wang D, Zhang B, Chen M, Chen J, Yan F, Rao S.   +6 more
europepmc   +1 more source

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source