Results 1 to 10 of about 20,636 (170)
High expression of human carboxypeptidase M in Pichia pastoris: Purification and partial characterization [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Carboxypeptidase M (CPM) is an extracellular glycosylphosphatidyl-inositol-anchored membrane glycoprotein, which removes the C-terminal basic residues, lysine and arginine, from peptides and proteins at neutral pH.
Craveiro R.B. +7 more
doaj +2 more sources
Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]
, 2012 Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Jarmoszewicz, Katarzyna +3 more
core +20 more sources
Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
Frontiers in Immunology, 2021 Mast cells are immune cells that store large amounts of mast cell-restricted proteases in their secretory granules, including tryptase, chymase and carboxypeptidase A3.
Sultan Alanazi +2 more
doaj +1 more source
Endogenously generated plasmin at the vascular wall injury site amplifies lysine binding site-dependent plasminogen accumulation in microthrombi. [PDF]
PLoS ONE, 2015 The fibrinolytic system plays a pivotal role in the regulation of hemostasis; however, it remains unclear how and when the system is triggered to induce thrombolysis.
Tomasz Brzoska +5 more
doaj +1 more source
Arginine and lysine as products of basic carboxypeptidase activity associated with fibrinolysis [PDF]
Biomeditsinskaya Khimiya, 2012 Blood carboxypeptidases play an important role in the regulation of fibrinolysis. We have proposed here the method for the assay of blood carboxypeptidase activity associated with coagulation/fibrinolysis using the natural substrate fibrin and the detection of basic amino acids arginine and lysine as products in the conditions close to those in vivo ...
A A, Zhloba +4 more
openaire +2 more sources
BMC Genomics, 2023 Background Oriental river prawn Macrobrachium nipponense is an economically important aquaculture species in China, Japan, and Vietnam. In commercial prawn farming, feed cost constitutes about 50 to 65% of the actual variable cost.
Feiyue Ling +6 more
doaj +1 more source
Improved chemical synthesis of hydrophobic Aβ peptides using addition of C‐terminal lysines later removed by carboxypeptidase B [PDF]
Peptide Science, 2014 ABSTRACTMany amyloidogenic peptides are highly hydrophobic, introducing significant challenges to obtaining high quality peptides by chemical synthesis. For example, while good yield and purity can be obtained in the solid‐phase synthesis of the Alzheimer's plaque peptide Aβ40, addition of a C‐terminal Ile‐Ala sequence to generate the more toxic Aβ42 ...
Saketh, Chemuru +2 more
openaire +2 more sources
Co-Catalytic Metallopeptidases as Pharmaceutical Targets [PDF]
, 2003 Understanding the reaction mechanism of co-catalytic metallopeptidases provides a starting point for the design and synthesis of new molecules that can be screened as potential pharmaceuticals. Many of the enzymes that contain co-catalytic metallo-active
Bzymek, Krzysztof P. +2 more
core +2 more sources
Lipids in Health and Disease, 2019 Background Atherosclerosis is an inflammatory process involving activation of monocytes recruited by various chemoattractant factors, among which lipoprotein(a) and its specific apolipoprotein apo(a). Lp(a) contains a specific apolipoprotein apo(a) which
Nadia Sabbah +4 more
doaj +1 more source
PLoS ONE, 2012 Carboxypeptidase M (CPM) targets the basic amino acids arginine and lysine present at the C-terminus of peptides or proteins. CPM is thought to be involved in inflammatory processes.
Catherine Denis +7 more
doaj +1 more source