Results 111 to 120 of about 1,291,574 (308)

A micro cell lysis device [PDF]

, 1998
A new micromachined cell lysis device is developed. It is designed for miniature bio-analysis systems where cell lysing is needed to obtain intracellular materials for further analysis such as DNA identification.
Lee, S. W., Tai, Y. C., Yowanto, H.
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Efficacy of Erwinia amylovora and Xanthomonas campestris pv campestris phages to control fire blight and black rot in vivo

Microbiology Spectrum
Phytopathogens, such as Erwinia amylovora and Xanthomonas campestris, pose significant threats to agriculture, leading to substantial economic losses.
Gloria Vique, Elena Mendoza-Barberá, Maria Dolores Ramos-Barbero, Pedro Blanco-Picazo, Laura Sala-Comorera, Pablo Quirós, Sergio Atares, Ignasi Salaet, Maite Muniesa, Lorena Rodríguez-Rubio   +9 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Phalangeal and metatarsal bone destruction by subungual squamous cell carcinoma complicated by Peptostreptococcus sp. infection in a dog – importance of histopathological diagnosis.

Medicina Veterinária, 2019
The present article reports the case and complications of a canine with a subungual squamous cell carcinoma infected with Peptostreptococcus sp.
Camila Barbosa Amaral, Mário Antônio Pinto Romão, Ana Maria Reis Ferreira   +2 more
doaj  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity [PDF]

, 1978
INFECTION of mice with viruses can generate cytotoxic T lymphocytes (CTL) which show restricted specificity for target cell lysis. Specific lysis requires that the virus used to prime the target cells must be of the same type as that used to sensitise ...
A Munro, A Scheid, H Tozawa, JW Schrader, K Sugamura, M Homma, MARY-JANE GETHING, MICHAEL WATERFIELD, RM Zinkernagel, U Koszinowski, U Koszinowski, ULRICH KOSZINOWSKI, Y Hosaka   +12 more
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Spatial heterogeneity and peptide availability determine CTL killing efficiency in vivo [PDF]

, 2014
The rate at which a cytotoxic T lymphocyte (CTL) can survey for infected cells is a key ingredient of models of vertebrate immune responses to intracellular pathogens. Estimates have been obtained using in vivo cytotoxicity assays in which peptide-pulsed
A Wiedemann, A Yates, AJ Yates, AL DeVico, AM Beal, AM Byers, Andrew Yates, AS Perelson, AS Perelson, AS Perelson, AS Perelson, B Breart, Benedict Seddon, Bjoern Peters, CA Macken, D Zagury, DH Busch, DL Barber, EA Grimm, ER Christinck, F Graw, F Graw, G Chu, LG Guidotti, M Bajénoff, M Poe, MA Purbhoo, MH Foley, MR Jenkins, P Perez, RR Regoes, RR Regoes, S Budhu, S Valitutti, SE Henrickson, SH van der Burg, Sim Tung, Thea Hogan, TR Mempel, Ulrich Kadolsky, VV Ganusov, VV Ganusov, VV Ganusov, VV Ganusov, W Barchet, Y Sykulev, YW Jung   +46 more
core   +4 more sources

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source