Results 71 to 80 of about 903,918 (305)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Cell Lysis via Surface Acoustic Waves (SAW)
At the laboratory scale, chemical lysis is the most commonly used method for cell disruption due to its high efficiency, low cost, and compatibility with analytical techniques like PCR and electrophoresis. However, chemical lysis has drawbacks related to
Almanza Alvarez, Gonzalo
core +1 more source
Tumor lysis syndrome rare presentation as uremic pericarditis: a case report
, 2023 Tumor lysis syndrome (TLS) is an oncological emergency characterized by the massive destruction of malignant cells and the release of their contents into the extracellular space, which might occur spontaneously or post-chemotherapy.
Pereira, Rafaela +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
A Mutant Isoform of ObgE Causes Cell Death by Interfering with Cell Division
Frontiers in Microbiology, 2017 Cell division is a vital part of the cell cycle that is fundamental to all life. Despite decades of intense investigation, this process is still incompletely understood.
Liselot Dewachter +13 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Lysis of a Single Cyanobacterium for Whole Genome Amplification
Micromachines, 2013 Bacterial species from natural environments, exhibiting a great degree of genetic diversity that has yet to be characterized, pose a specific challenge to whole genome amplification (WGA) from single cells. A major challenge is establishing an effective,
Richard N. Zare +3 more
doaj +1 more source
Lysis of lysis-inhibited bacteriophage T4-infected cells [PDF]
Journal of Bacteriology, 1992 T4 bacteriophage (phage)-infected cells show a marked increase in latent-period length, called lysis inhibition, upon adsorption of additional T4 phages (secondary adsorption). Lysis inhibition is a complex phenotype requiring the activity of at least six T4 genes. Two basic mysteries surround our understanding of the expression of lysis inhibition: (i)
openaire +2 more sources
Les capitalistes français contre la France /
, 1916 Lysis is the pseudonym of Eugène Le Tailleur.Mode of access ...
Lysis.
core
, 2015 Representative experiments showing clot lysis with fluorescein-labeled plasma clots by tPA (A) and M5 (B) using the three highest doses up to the point at which no further shortening of the lysis time could be achieved.
Victor Gurewich (213767) +2 more
core +1 more source