Results 61 to 70 of about 903,918 (305)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Isolation and Characterization of Lytic Phages Infecting Clinical Klebsiella pneumoniae from Tunisia

Antibiotics
Background: Klebsiella pneumoniae is an opportunistic pathogen that causes a wide range of infections worldwide. The emergence and spread of multidrug-resistant clones requires the implementation of novel therapeutics, and phages are a promising approach.
Donia Mourali, Rahma Kazdaghli, Marwa Gara-Ali, Houda Ben-Miled, Lucas Mora-Quilis, Pilar Domingo-Calap, Kamel Ben-Mahrez   +6 more
doaj   +1 more source

Tumor lysis syndrome: review of pathogenesis, risk factors and management of a medical emergency

, 2016
Tumor lysis syndrome (TLS) is a rare but potentially life-threatening complication of neoplasms, preferentially hematological malignancies. Well known since at least ninety years ago, this condition can be misdiagnosed and incorrectly managed due to ...
Criscuolo, Marianna, Fianchi, Luana, Pagano, Livio   +2 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Metabolic Response of Faecalibacterium prausnitzii to Cell-Free Supernatants from Lactic Acid Bacteria

Microorganisms, 2020
Interest in preventive or therapeutic strategies targeting gut microbiota is increasing. Such strategies may involve the direct replenishment of the gut microbiota with single strains or strain mixtures, or the manipulation of strain abundance through ...
Mathilde Lebas, Peggy Garault, Daniel Carrillo, Francisco M. Codoñer, Muriel Derrien   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Active Human Complement Reduces the Zika Virus Load via Formation of the Membrane-Attack Complex

Frontiers in Immunology, 2018
Although neglected in the past, the interest on Zika virus (ZIKV) raised dramatically in the last several years. The rapid spread of the virus in Latin America and the association of the infection with microcephaly in newborns or Guillain-Barré Syndrome ...
Britta Schiela, Sarah Bernklau, Zahra Malekshahi, Daniela Deutschmann, Iris Koske, Zoltan Banki, Nicole M. Thielens, Reinhard Würzner, Cornelia Speth, Guenter Weiss, Karin Stiasny, Eike Steinmann, Heribert Stoiber   +12 more
doaj   +1 more source

Clot formation and lysis in platelet rich plasma of healthy donors and patients with resistant hypertension [PDF]

The Ukrainian Biochemical Journal, 2018
Hemostatic balance in blood is affected by numerous factors, including coagulation and fibrinolytic proteins, the wide spectrum of their inhibitors, and blood cells.
I. I. Patalakh, O. V. Revka, O. B. Kuchmenko, O. O. Matova, T. F. Drobotko, T. V. Grinenko   +5 more
doaj   +1 more source

BridgesLabCMU/Lysis-sensing-scripts: Paper scripts

<p>Sample scripts for analyzing brightfield timelapses for the manuscript "Cell-lysis sensing drives biofilm formation in <em>Vibrio cholerae</em>"</p ...
Jojo Prentice
core   +1 more source

A new device for measurement of fibrin clot lysis: application to the euglobulin clot lysis time. [PDF]

, 2002
Determination of clot lysis times on whole blood, diluted whole blood, plasma or plasma fraction has been used for many years to assess the overall activity of the fibrinolytic system. We designed a completely computerised semi-automatic 8-channel device
Boudjeltia K Zouaoui, K Zouaoui Boudjeltia, M Guillaume, Zouaoui Boudjeltia, Karim, Vanhaeverbeek, Michel, Remacle Cl, Cauchie Ph, Brohée, Dany, M Vanhaeverbeek, Vanhaeverbeek M, Brohée D, Guillaume, Michel, Guillaume M, Hubert, J L, Hubert JL, D Brohée, JL Hubert, Remacle, Claude, Ph Cauchie, Cl Remacle, Cauchie, Philippe   +20 more
core   +1 more source