Phage-mediated resolution of genetic conflict alters the evolutionary trajectory of Pseudomonas aeruginosa lysogens [PDF]
mSystemsThe opportunistic human pathogen Pseudomonas aeruginosa is naturally infected by a large class of temperate, transposable, Mu-like phages. We examined the genotypic and phenotypic diversity of P.
Laura C. Suttenfield +6 more
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Screening for Lysogen Activity in Therapeutically Relevant Bacteriophages
Bio-Protocol, 2021 Lysogenic phages can integrate into their bacterial host’s genome, potentially transferring any genetic information they possess including virulence or resistance genes, and are therefore routinely excluded from therapeutic applications.
Fernando Gordillo Altamirano +1 more
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Precision targeting of genetic variations in mixed bacterial cultures using CRISPR-Cas12a-programmed λ phages [PDF]
Frontiers in MicrobiologyThe CRISPR-Cas system, an adaptive immune mechanism in prokaryotes against bacteriophages, has been developed into a versatile tool for recognizing and cleaving target nucleic acid sequences.
Chan Kyeong Lee +3 more
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Lysogen stability is determined by the frequency of activity bursts from the fate‐determining gene
Molecular Systems Biology, 2010 The ability of living cells to maintain an inheritable memory of their gene‐expression state is key to cellular differentiation. Bacterial lysogeny serves as a simple paradigm for long‐term cellular memory.
Chenghang Zong +4 more
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Effect of temperate bacteriophage vB_SauS_S1 on the adaptability and pathogenicity of Staphylococcus aureus ST398 [PDF]
BMC MicrobiologyLivestock-associated Staphylococcus aureus ST398 is a highly pathogenic species that causes infections in a wide variety of animals, including humans.
Hui Liu +8 more
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Human Serum Mediated Bacteriophage Life Cycle Switch in Aggregatibacter actinomycetemcomitans Is Linked to Pyruvate Dehydrogenase Complex [PDF]
Life, 2023 Antimicrobial resistance is rising as a major global public health threat and antibiotic resistance genes are widely spread among species, including human oral pathogens, e.g., Aggregatibacter actinomycetemcomitans.
Gaoyan Grace Tang-Siegel
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Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host strain, and antibiotic pairing [PDF]
mBioBacteriophages (phages) are bacterial-specific viruses that can be used alone or with antibiotics to reduce bacterial load. Most phages are unsuitable for therapy because they are “temperate” and can integrate into the host genome, forming a lysogen that
Rabia Fatima, Alexander P. Hynes
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Identification of genes expressed in cultures of
BMC Microbiology, 2012 Background Shigatoxigenic E. coli are a global and emerging health concern. Shiga toxin, Stx, is encoded on the genome of temperate, lambdoid Stx phages. Genes essential for phage maintenance and replication are encoded on approximately 50% of the genome,
Riley Laura M +5 more
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What makes a temperate phage an effective bacterial weapon? [PDF]
mSystemsTemperate bacteriophages (phages) are common features of bacterial genomes and can act as self-amplifying biological weapons, killing susceptible competitors and thus increasing the fitness of their bacterial hosts (lysogens).
M. J. N. Thomas +2 more
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PLoS Genetics, 2022 Most bacterial genomes contain horizontally acquired and transmissible mobile genetic elements, including temperate bacteriophages and integrative and conjugative elements.
Christopher M Johnson +2 more
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