Synergy between ciprofloxacin and temperate phages overcomes therapeutic limitations caused by lysogen formation [PDF]
Scientific ReportsBacteriophages have proven invaluable in combatting drug-resistant bacteria. Bias towards exclusive use of obligately lytic phages has restricted the range of phage therapy, however, since at least half of all Caudovirecetes are temperate, and such ...
P. Lauman +2 more
doaj +2 more sources
Enhanced efficiency of virulent and temperate phage combination mediated through bacterial membrane vesicles [PDF]
Journal of VirologySince multidrug-resistant Vibrio parahaemolyticus (VP), a deadly pathogenic bacterium responsible for acute hepatopancreatic necrosis disease (AHPND), which has increasingly emerged, bacteriophages have been focused on as an alternative therapy against ...
Panida Saeju +5 more
doaj +2 more sources
Effect of temperate bacteriophage vB_SauS_S1 on the adaptability and pathogenicity of Staphylococcus aureus ST398 [PDF]
BMC MicrobiologyLivestock-associated Staphylococcus aureus ST398 is a highly pathogenic species that causes infections in a wide variety of animals, including humans.
Hui Liu +8 more
doaj +2 more sources
Genomic analysis and lysogenic conversion of novel RAP44-like phages in Riemerella anatipestifer [PDF]
Poultry ScienceRiemerella anatipestifer, an important waterfowl pathogen, causes severe economic losses because of limited prevention and control methods. We aimed to characterize the prophages of R.
Junxuan Zhang +10 more
doaj +2 more sources
Precision targeting of genetic variations in mixed bacterial cultures using CRISPR-Cas12a-programmed λ phages [PDF]
Frontiers in MicrobiologyThe CRISPR-Cas system, an adaptive immune mechanism in prokaryotes against bacteriophages, has been developed into a versatile tool for recognizing and cleaving target nucleic acid sequences.
Chan Kyeong Lee +3 more
doaj +2 more sources
Lysogenic control of Bacillus subtilis morphology and fitness by Spbetavirus phi3T [PDF]
Communications BiologyIn lysogenic conversion, temperate phages can profoundly alter the phenotypes of their bacterial hosts. When studying the effects of SPbeta-like viruses on a Bacillus subtilis soil isolate, we observed that phage phi3T induced a stable and heritable ...
Valentina A. Floccari +10 more
doaj +2 more sources
Phage-mediated resolution of genetic conflict alters the evolutionary trajectory of Pseudomonas aeruginosa lysogens [PDF]
mSystemsThe opportunistic human pathogen Pseudomonas aeruginosa is naturally infected by a large class of temperate, transposable, Mu-like phages. We examined the genotypic and phenotypic diversity of P.
Laura C. Suttenfield +6 more
doaj +2 more sources
Temperate phage-antibiotic synergy is widespread—extending to Pseudomonas—but varies by phage, host strain, and antibiotic pairing [PDF]
mBioBacteriophages (phages) are bacterial-specific viruses that can be used alone or with antibiotics to reduce bacterial load. Most phages are unsuitable for therapy because they are “temperate” and can integrate into the host genome, forming a lysogen that
Rabia Fatima, Alexander P. Hynes
doaj +2 more sources
Noncanonical amino acids as prophage inducers for protein regulation in bacteria-based delivery systems [PDF]
mBioGenetically engineered bacteria represent a promising drug delivery tool for disease treatment. The development of new strategies for specific and independent protein regulation is necessary, especially for combination protein drug therapy.
Hongfang Liu +8 more
doaj +2 more sources
What makes a temperate phage an effective bacterial weapon? [PDF]
mSystemsTemperate bacteriophages (phages) are common features of bacterial genomes and can act as self-amplifying biological weapons, killing susceptible competitors and thus increasing the fitness of their bacterial hosts (lysogens).
M. J. N. Thomas +2 more
doaj +2 more sources