Non-conventional therapeutic technique to replace CRISPR bacteria from biofilm by inducible lysogen [PDF]
Journal of Biological Dynamics, 2019 Bacteriophage can be an effective means of regulating bacterial populations when conditions allow phage invasion of bacterial colonies. Phage can either infect and lyse a host cell, or insert their DNA into the host cell genome; the latter process is ...
Qasim Ali
doaj +2 more sources
Synergy between ciprofloxacin and temperate phages overcomes therapeutic limitations caused by lysogen formation [PDF]
Scientific ReportsBacteriophages have proven invaluable in combatting drug-resistant bacteria. Bias towards exclusive use of obligately lytic phages has restricted the range of phage therapy, however, since at least half of all Caudovirecetes are temperate, and such ...
P. Lauman +2 more
doaj +2 more sources
Enhanced efficiency of virulent and temperate phage combination mediated through bacterial membrane vesicles [PDF]
Journal of VirologySince multidrug-resistant Vibrio parahaemolyticus (VP), a deadly pathogenic bacterium responsible for acute hepatopancreatic necrosis disease (AHPND), which has increasingly emerged, bacteriophages have been focused on as an alternative therapy against ...
Panida Saeju +5 more
doaj +2 more sources
Identification of genes expressed in cultures of
BMC Microbiology, 2012 Background Shigatoxigenic E. coli are a global and emerging health concern. Shiga toxin, Stx, is encoded on the genome of temperate, lambdoid Stx phages. Genes essential for phage maintenance and replication are encoded on approximately 50% of the genome,
Riley Laura M +5 more
doaj +2 more sources
Effect of temperate bacteriophage vB_SauS_S1 on the adaptability and pathogenicity of Staphylococcus aureus ST398 [PDF]
BMC MicrobiologyLivestock-associated Staphylococcus aureus ST398 is a highly pathogenic species that causes infections in a wide variety of animals, including humans.
Hui Liu +8 more
doaj +2 more sources
Genomic analysis and lysogenic conversion of novel RAP44-like phages in Riemerella anatipestifer [PDF]
Poultry ScienceRiemerella anatipestifer, an important waterfowl pathogen, causes severe economic losses because of limited prevention and control methods. We aimed to characterize the prophages of R.
Junxuan Zhang +10 more
doaj +2 more sources
Precision targeting of genetic variations in mixed bacterial cultures using CRISPR-Cas12a-programmed λ phages [PDF]
Frontiers in MicrobiologyThe CRISPR-Cas system, an adaptive immune mechanism in prokaryotes against bacteriophages, has been developed into a versatile tool for recognizing and cleaving target nucleic acid sequences.
Chan Kyeong Lee +3 more
doaj +2 more sources
Phage-mediated resolution of genetic conflict alters the evolutionary trajectory of Pseudomonas aeruginosa lysogens [PDF]
mSystemsThe opportunistic human pathogen Pseudomonas aeruginosa is naturally infected by a large class of temperate, transposable, Mu-like phages. We examined the genotypic and phenotypic diversity of P.
Laura C. Suttenfield +6 more
doaj +2 more sources
Lysogenic control of Bacillus subtilis morphology and fitness by Spbetavirus phi3T [PDF]
Communications BiologyIn lysogenic conversion, temperate phages can profoundly alter the phenotypes of their bacterial hosts. When studying the effects of SPbeta-like viruses on a Bacillus subtilis soil isolate, we observed that phage phi3T induced a stable and heritable ...
Valentina A. Floccari +10 more
doaj +2 more sources
Commensal E. coli Stx2 lysogens produce high levels of phages after spontaneous prophage induction [PDF]
Frontiers in Cellular and Infection Microbiology, 2015 Enterohemorrhagic E. coli (EHEC) is a food-borne pathogen that causes disease ranging from uncomplicated diarrhea to life-threatening hemolytic uremic syndrome (HUS) and nervous system complications.
Hildegunn eIversen +4 more
doaj +2 more sources