Results 131 to 140 of about 31,028 (221)

Intranuclear Signaling Cascades Triggered by Nuclear GPCRs

, 2016
G protein-couped receptors (GPCRs) play a key role on cellular membranes, where they respond to a broad array of extracellular signals such as lipids, peptides, proteins and sensory agents.
AMMENDOLA, ROSARIO, CATTANEO, FABIO, ESPOSITO, GABRIELLA, Fioretti, Tiziana, PARISI, MELANIA   +4 more
core   +1 more source

Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling. [PDF]

Exp Biol Med (Maywood), 2023
Janovicz A, Majer A, Kosztelnik M, Geiszt M, Chun J, Ishii S, Tigyi GJ, Benyó Z, Ruisanchez É.   +8 more
europepmc   +1 more source

In vitro pharmacological characterization of standard and new lysophosphatidic acid receptor antagonists using dynamic mass redistribution assay. [PDF]

Front Pharmacol, 2023
Ruzza C, Argentieri M, Ferrari F, Armani E, Trevisani M, Marchini G, Calo' G.   +6 more
europepmc   +1 more source

Gintonin Binds to Reduced LPA4 Receptor Subtype in Human Cortical Neurons in Alzheimer’s Disease Brains

Biomolecules
Ginseng, a traditional herbal medicine with a long history of use, is known to support human health, particularly by influencing brain function. Recent studies have identified gintonin, a lysophosphatidic acid (LPA) receptor ligand derived from ginseng ...
Kyu-Sung Kim, Rami Lee, Inyeong Park, Sung-Hee Hwang, Yeshin Kim, Jae-Won Jang, Hyung-Seok Kim, Seong-Min Choi, Sang Jin Kim, Hwa Jin Cho, Ik-Hyun Cho, Jong-Hoon Kim, Do-Geun Kim, Seung-Yeol Nah   +13 more
doaj   +1 more source

Discovery of Chemical Scaffolds as Lysophosphatidic Acid Receptor 1 Antagonists: Virtual Screening, In Vitro Validation, and Molecular Dynamics Analysis. [PDF]

ACS Omega, 2023
Nguyen LP, Khan RA, Kang S, Lee H, Hwang JI, Kim HR.   +5 more
europepmc   +1 more source

Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer. [PDF]

Pharmacol Ther, 2023
Dacheux MA, Norman DD, Tigyi GJ, Lee SC.
europepmc   +1 more source

Lysophosphatidic Acid Receptor Signaling in the Human Breast Cancer Tumor Microenvironment Elicits Receptor-Dependent Effects on Tumor Progression. [PDF]

Int J Mol Sci, 2023
Benesch MGK, Wu R, Tang X, Brindley DN, Ishikawa T, Takabe K.   +5 more
europepmc   +1 more source

Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model. [PDF]

Proc Natl Acad Sci U S A, 2022
Axelsson Raja A, Wakimoto H, DeLaughter DM, Reichart D, Gorham J, Conner DA, Lun M, Probst CK, Sakai N, Knipe RS, Montesi SB, Shea B, Adam LP, Leinwand LA, Wan W, Choi ES, Lindberg EL, Patone G, Noseda M, Hübner N, Seidman CE, Tager AM, Seidman JG, Ho CY.   +23 more
europepmc   +1 more source

Potassium channels of the K2P-family control the activity of neuronal cells - TRESK as regulator of inflammatory hyperalgesia [PDF]

, 2015
Das Empfinden von Schmerz ist für uns überlebenswichtig. Chronischer Schmerz hingegen hat seine physiologische Bedeutung verloren und wird als eigenes Krankheitsbild angesehen. Schmerzempfindung beginnt mit der Nozizeption.
Kollert, Sina
core  

Structure of the active G_i-coupled human lysophosphatidic acid receptor 1 complexed with a potent agonist. [PDF]

Nat Commun, 2022
Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O.   +5 more
europepmc   +1 more source