Results 181 to 190 of about 31,028 (221)
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Lysophosphatidic Acid Receptors
Molecular Pharmacology, 2000Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression.
J J, Contos, I, Ishii, J, Chun
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Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5
Biochemical and Biophysical Research Communications, 2023Cannabinoid receptor 2 (CB2) and lysophosphatidic acid receptor 5 (LPA5) are both classified as G-protein coupled receptors (GPCRs) activated by bioactive lipids and are highly expressed in colon cancer cells. However, crosstalk between two receptors and its potential effects on cancer cell physiology have not been fully elucidated.
Eunju Song, Sungho Ghil
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Lysophosphatidic acid (LPA) and its receptors
Current Opinion in Pharmacology, 2009Lysophosphatidic acid (LPA), a bioactive phospholipid, and its family of cognate G protein-coupled receptors have demonstrated roles in many biological functions in the nervous system. To date, five LPA receptors have been identified, and additional receptors may exist.
Kyoko, Noguchi +3 more
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Lysophosphatidic acid: receptors, signaling and survival
Cellular and Molecular Life Sciences, 2000Though the mitogenic activity of lysophosphatidic acid (LPA) has been well established through classical studies, its mechanism of action was long obscure. Recent identification and cloning of LPA-specific receptors has led to the elucidation of the G-proteins and signaling pathways through which this molecule functions.
J T, Swarthout, H W, Walling
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Biochemical and Biophysical Research Communications, 1993
The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear.
S, Shiono +4 more
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The significance of phospholipase D in metabolic regulation is being recognized. The products of phospholipase D action are phosphatidic acid and lysophosphatidic acid (LPA). Whether these lipid products exert their effect through plasma membrane receptor-mediated mechanism is not yet clear.
S, Shiono +4 more
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Non-Edg family lysophosphatidic acid (LPA) receptors
Prostaglandins & Other Lipid Mediators, 2009Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a bioactive phospholipid with mitogenic and/or morphological effects on many cell types. In addition, LPA has been reported to play important roles in various biological processes. It was originally thought that the cellular effects of LPA are mediated by three subtypes of G-protein ...
Satoshi, Ishii +2 more
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GPR35 is a novel lysophosphatidic acid receptor
Biochemical and Biophysical Research Communications, 2010GPR35 is a rhodopsin-like G protein-coupled receptor identified in 1998. It has been reported that kynurenic acid, a tryptophan metabolite, may act as an endogenous ligand for GPR35. However, the concentrations of kynurenic acid required to elicit the cellular responses are usually high, raising the possibility that another endogenous ligand may exist.
Saori, Oka +4 more
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Molecular basis for lysophosphatidic acid receptor antagonist selectivity
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Recent characterization of lysophosphatidic acid (LPA) receptors has made possible studies elucidating the structure-activity relationships (SAR) for agonist activity at individual receptors. Additionally, the availability of these receptors has allowed the identification of antagonists of LPA-induced effects.
Vineet M, Sardar +9 more
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Comparative analyses of lysophosphatidic acid receptor-mediated signaling
Cellular and Molecular Life Sciences, 2015Lysophosphatidic acid (LPA) is a bioactive lipid mediator that activates G protein-coupled LPA receptors to exert fundamental cellular functions. Six LPA receptor genes have been identified in vertebrates and are classified into two subfamilies, the endothelial differentiation genes (edg) and the non-edg family.
Nobuyuki, Fukushima +4 more
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Lysophosphatidic acid-1-receptor targeting agents for fibrosis
Expert Opinion on Investigational Drugs, 2011The presence of fibrosis is associated with alterations in organ architecture and is responsible for the morbidity of diseases including pneumopathies, systemic sclerosis, liver cirrhosis, chronic cardiovascular diseases, progressive kidney diseases and diabetes.
Rancoule, Chloé +7 more
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