Results 191 to 200 of about 31,028 (221)
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Functional lysophosphatidic acid receptors expressed in Oryzias latipes
Gene, 2014Lysophosphatidic acid (LPA) signaling is known to play biological and pathophysiological roles in many types of animals. Medaka (Oryzias latipes) is an experimental fish that can be easily maintained, propagated, and analyzed, and whose genome has been completely sequenced. However, there is limited information available regarding medaka LPA receptors.
Yuji, Morimoto +6 more
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Lysophosphatidic acid stimulates pericyte migration via LPA receptor 1
Biochemical and Biophysical Research Communications, 2022Lysophosphatidic acid (LPA) is a bioactive compound known to regulate various vascular functions. However, despite the fact that many vascular functions are regulated by peri-vascular cells such as pericytes, the effect of LPA on brain pericytes has not been fully evaluated. Thus, we designed this study to evaluate the effects of LPA on brain pericytes.
Yoshino Yonezu +3 more
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Characterization of a Receptor Subtype-Selective Lysophosphatidic Acid Mimetic
Molecular Pharmacology, 1998Despite an intriguing cell biology and the suggestion of a role in pathophysiological responses, the mechanism of action of such lipid phosphoric acid mediators as lysophosphatidic acid (LPA) remains obscure, in part because of an underdeveloped medicinal chemistry.
S B, Hooks +6 more
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Stereochemical properties of lysophosphatidic acid receptor activation and metabolism
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Ligand recognition by G protein-coupled receptors (GPCR), as well as substrate recognition by enzymes, almost always shows a preference for a naturally occurring enantiomer over the unnatural one. Recognition of lysophosphatidic acid (LPA) by its receptors is an exception, as both the natural L (R) and unnatural D (S) stereoisomers of LPA are equally ...
Kazuaki, Yokoyama +6 more
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Lysophosphatidic acid receptor (LPAR) modulators: The current pharmacological toolbox
Progress in Lipid Research, 2015Lysophosphatidic acids (LPA) are key lipid-signalling molecules that regulate a remarkably diverse set of cellular events, such as motility, chemotaxis, cell cycle progression, viability, and wound healing. The physiological and pathophysiological consequences of LPA signalling are evident and misregulation of LPA signalling can lead to pathologies ...
Sabin Llona-Minguez +2 more
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Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
Nature Medicine, 2004Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the development of neuropathic pain by pharmacological and genetic approaches, including the use of mice lacking the LPA(1) receptor.
Makoto, Inoue +5 more
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Identification and characterization of a lysophosphatidic acid receptor.
Molecular Pharmacology, 1994A specific binding site for 1-[3H]stearoyl-lysophosphatidic acid (stearoyl-LPA) was identified and characterized in membranes prepared from rat brain and Swiss 3T3 fibroblasts. Specific binding of [3H]LPA to these sites was protein dependent, was saturable, reached equilibrium in 15 min, and was displacable by the addition of excess unlabeled LPA ...
F J, Thomson +3 more
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Regulation of Lysophosphatidic acid receptor 3
The Journal of Pharmacology and Experimental Therapeutics, 2023Karina Helivier Solís +2 more
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