Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]
, 2014 The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
A Boucharaba +72 more
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The Function of NM23-H1/NME1 and Its Homologs in Major Processes Linked to Metastasis [PDF]
, 2020 International ...
Boissan, Mathieu +6 more
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In silico analysis of missense mutations in LPAR6 reveals abnormal phospholipid signaling pathway leading to hypotrichosis. [PDF]
PLoS ONE, 2014 Autosomal recessive hypotrichosis is a rare genetic irreversible hair loss disorder characterized by sparse scalp hair, sparse to absent eyebrows and eyelashes, and sparse axillary and body hair.
Syed Irfan Raza +6 more
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Lysophosphatidic acid receptors in cancer pathobiology.
Histology and histopathology, 2014 Lysophosphatidic acid (LPA) receptors (LPA₁ to LPA₆) are G protein-coupled transmembrane and mediate a variety of biological responses through the binding of LPA, such as cell proliferation, migration, morphogenesis and differentiation. Previously, high secretion levels of LPA were found in blood and ascites from patients with aggressive ovarian cancer.
Tsujiuchi, Toshifumi +4 more
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Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]
, 2019 Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C +4 more
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Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein [PDF]
, 2006 Oxidation of low-density lipoprotein (LDL) generates pro-inflammatory and pro-thrombotic mediators that play a crucial role in cardiovascular and inflammatory diseases.
Siess, Wolfgang
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Lysophosphatidic acid receptor agonists and antagonists (WO2010051053) [PDF]
Expert Opinion on Therapeutic Patents, 2011 Lysophosphatidic acid (LPA) is a bioactive lipid involved in signaling pathways that result in cell survival, proliferation, migration and invasion. These cellular responses are a critical element of both normal development as well as pathophysiology.
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TRIP6 Enhances Lysophosphatidic Acid-induced Cell Migration by Interacting with the Lysophosphatidic Acid 2 Receptor [PDF]
Journal of Biological Chemistry, 2004 Lysophosphatidic acid (LPA) induces actin rearrangement, focal adhesion assembly, and cell migration through the activation of small G protein Rho and its downstream effectors. These diverse cellular responses are mediated by its associated G protein-coupled receptors.
Jun, Xu +3 more
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Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3. [PDF]
PLoS ONE, 2015 The lysophosphatidic acid receptors LPA1, LPA2, and LPA3 were individually expressed in C9 cells and their signaling and regulation were studied. Agonist-activation increases intracellular calcium concentration in a concentration-dependent fashion ...
Rocío Alcántara-Hernández +4 more
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A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. [PDF]
, 2016 With the passing of Dr. Robert Bittman from pancreatic cancer on the 1st October 2014, the lipid research field lost one of the most influential and significant personalities.
Pyne, Nigel J., Tigyi, Gabor J.
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