Results 111 to 120 of about 24,337 (222)

Ustilago maydis Phosphatidic Acid and Phosphatidylserine‐Targeting Secreted Lipase Lip3 Is Involved in Pathogenesis

Molecular Plant Pathology, Volume 27, Issue 5, May 2026.
Ustilago maydis secreted lipase, Lip3 targets PA and PS and alkalinises the host apoplast, thus promoting virulence. Loss of Lip3 results in reduced apoplastic pH and decreased pathogenicity. ABSTRACT Lipases constitute important virulence factors. By targeting specific lipids involved in various cellular processes, lipases regulate growth, development,
Anisha Roy, Rituparna Mondal, Anupama Ghosh   +2 more
wiley   +1 more source

The Regulation and Function of Hippo/YAP Pathway in Cancer

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Hippo/YAP pathway signaling plays critical roles in the progression of multiple cancer types. This review summarizes current knowledge of Hippo/YAP pathway regulation and function in cancer. We discuss the core components of the Hippo/YAP pathway; its crosstalk with other signaling pathways; regulation by non‐coding RNAs; roles of YAP signaling in ...
Chinmoy Ghosh, Ruchi Kakar, Seline Torkamboor, Yue Sun   +3 more
wiley   +1 more source

Direct genetic demonstration of Gα13 coupling to the orphan G protein-coupled receptor G2A leading to RhoA-dependent actin rearrangement [PDF]

, 2000
G2A is an orphan G protein-coupled receptor (GPCR), expressed predominantly in T and B cells and homologous to a small group of GPCRs of unknown function expressed in lymphoid tissues.
Feramisco, Jamison D., Gu, Jennifer L., Kabarowski, Janusz H. S., Le, Lu Q., Luoh, Shiuh-Wen, Simon, Melvin I., Witte, Owen N.   +6 more
core  

Gintonin absorption in intestinal model systems

Journal of Ginseng Research, 2018
Background: Recently, we identified a novel ginseng-derived lysophosphatidic acid receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing ...
Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah   +7 more
doaj   +1 more source

Expression of lysophosphatidic acid receptors in the rat uterus: cellular distribution of protein and gestation-associated changes in gene expression. [PDF]

J Vet Med Sci, 2023
Kurusu S, Terashima R, Sugiyama M, Tanaka M, Kadowaki T, Kizaki K, Kawaminami M.   +6 more
europepmc   +1 more source

Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control

The Journal of Physiology, EarlyView.
Richard J. A. Wilson, Nicholas Jendzjowsky   +1 more
wiley   +1 more source

ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]

, 2009
Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Fadi AlDehni, Jiraporn Ousingsawat, Joana Almaç, Karl Kunzelmann, Rainer Schreiber, Ralph Witzgall, René   +6 more
core   +2 more sources

Higher LPA2 and LPA6 mRNA Levels in Hepatocellular Carcinoma Are Associated with Poorer Differentiation, Microvascular Invasion and Earlier Recurrence with Higher Serum Autotaxin Levels.

PLoS ONE, 2016
Hepatocellular carcinoma (HCC) commonly develops in patients with liver fibrosis; in these patients, the blood levels of lysophosphatidic acid (LPA) and its generating enzyme autotaxin (ATX) increase with the liver fibrosis stage. We aimed to examine the
Kenichiro Enooku, Baasanjav Uranbileg, Hitoshi Ikeda, Makoto Kurano, Masaya Sato, Hiroki Kudo, Harufumi Maki, Kazuhiko Koike, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi   +10 more
doaj   +1 more source

Lysophosphatidic acid receptors 2 and 3 regulate erythropoiesis at different hematopoietic stages. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids, 2021
Chiang JC, Chen WM, Lin KH, Hsia K, Ho YH, Lin YC, Shen TL, Lu JH, Chen SK, Yao CL, Chen BPC, Lee H.   +11 more
europepmc   +1 more source

Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions [PDF]

, 2015
Several clinical trials are exploring therapeutic effect of human CD34(+) cells in ischemic diseases, including myocardial infarction. Unfortunately, most of the cells die few days after delivery.
Aday, S, Cardoso, C, Carvalheiro, T, Carvalho, L, Duarte, A, Ferreira, L, Fidalgo-Carvalho, I, Gonçalves, L, Grãos, M, Kostic, I, Paiva, A, Vazão, H   +11 more
core   +1 more source