Results 131 to 140 of about 39,809 (251)

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, Volume 183, Issue 9, Page 1939-1957, May 2026.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Serum Metabolomics Study Reveals a Diagnostic Model for Lung Cancer Brain Metastasis

The Clinical Respiratory Journal, Volume 20, Issue 5, May 2026.
The overall workflow of noninvasive and efficient early diagnostic methods and key features of metabolic dysregulation associated with lung cancer brain metastasis, providing novel molecular insights into its pathogenesis and laying a foundation for future translational applications.
Hongxia Zhu, Yinuo Jin, Xin You, Qi Wang
wiley   +1 more source

Adipose Triglyceride Lipase and Gpr40 Contribute to the Anti‐Contractile Effect of Perivascular Adipose Tissue

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Objective Perivascular adipose tissue (PVAT) surrounds most peripheral blood vessels and exerts an anti‐contractile influence through paracrine mediators. Although numerous vasoactive factors have been identified, the mechanisms linking adipocyte metabolism to PVAT‐dependent modulation of vascular tone remain poorly defined. Because adipocytes
Miranda Hyatt, Rinaldo Rodrigues Dos Passos, Fenix A. Araujo, Emily W. Wilson, Emily W. Waigi, Tiago J. Costa, Darízy F. Silva, R. Clinton Webb, Camilla F. Wenceslau, Cameron G. McCarthy   +9 more
wiley   +1 more source

Lysophosphatidylcholin [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +2 more sources

Abscisic Acid Induces Triacylglycerol Accumulation and Lipid Remodelling in Chloroplast‐Containing Green Tissues of Lemna minor

Plant, Cell &Environment, Volume 49, Issue 5, Page 2464-2479, May 2026.
ABSTRACT Lipid remodelling is a fundamental component of plant responses to environmental stress and development, yet its regulation in fast‐growing aquatic plants remains poorly understood. Here, we investigated how abscisic acid (ABA) regulates triacylglycerol (TAG) accumulation and fatty acid (FA) composition in the duckweed Lemna minor.
Eunbi Kim, Bae Young Choi, Sujeong Je, Joohyun Kang, Seungwoo Shin, Yoomi Roh, Min Kim, Shogo Ito, Tokitaka Oyama, Yuree Lee, Donghwan Shim, Yasuyo Yamaoka   +11 more
wiley   +1 more source

Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non‐human primate fetal lung

Experimental Physiology, Volume 111, Issue 5, Page 2713-2728, 1 May 2026.
Abstract Restriction of fetal substrate supply has an adverse effect on surfactant maturation in the lung and thus affects the transition from in utero placental oxygenation to pulmonary ventilation ex utero. However, the consequences of reduced fetal substrate supply are dependent on the timing of gestation, severity and duration.
Mitchell C. Lock, Hillary F. Huber, Cun Li, Sandra Orgeig, Peter W. Nathanielsz, Janna L. Morrison   +5 more
wiley   +1 more source

リン脂質過酸化物の生物有機化学的合成 [PDF]

, 2010
Chemoenzymatic synthesis of 1-stearoyl-2-hydropeoxyacyl-sn-glycerophospholipids including phosphatidylcholine (PC-OOH), phosphatidic acid (PA-OOH), phosphatidylethanolamine (PE-OOH), phosphatidylglycerol (PG-OOH) and phosphatidylserine (PS-OOH).
Aoishi, Akihiro, Baba, Naomichi, Daido, Hiroko, Iwasa, Junkichi, Kaneko, Takao, Kishida, Yasuhiro, Matsuo, Mitsuyoshi, Nakajima, Shuhei, Sasakura, Keiji, Shigeta, Yasutami, Shimizu, Sakayu, Tahara, Shoichi, Yoneda, Kenji   +12 more
core  

Liver‐Specific Suppression of PLA2G6/iPLA2β Improves Glucose and Lipid Metabolism in High‐Fat Diet‐Fed Mice

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Liver‐specific suppression of PLA2G6/iPLA2β by utilizing the short‐hairpin RNA knockdown technique using an adenovirus vector (Ad‐shPLA2G6) altered phospholipid and fatty acid metabolites and suppressed hepatic lipid accumulation, serum triglyceride, and fasting glucose levels.
Kahori Shimizu, Mana Nishibata, Katsuyuki Nagata, Sho Hori, Shotaro Michinaga, Miyuki Kanehara, Miho Hashimoto‐Iwasaki, Fuminori Sakurai, Hideo Shindou, Koji Tomita, Toru Nishinaka, Hiroyuki Mizuguchi   +11 more
wiley   +1 more source

Possible Involvement of Lysophospholipids in Severe Asthma as Novel Lipid Mediators

Biomolecules
In severe asthma, symptoms are unstable despite intensive treatment based on high doses of inhaled corticosteroids and on-demand use of oral corticosteroids.
Hiroaki Kume, Kentaro Kazama, Riko Sato, Yuki Sato   +3 more
doaj   +1 more source