Results 161 to 170 of about 27,042 (202)
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Inflammation Research, 2012
The aim of this study was to examine the inflammation induced by saturated acyl lysophosphatidylcholine (LPC) in vivo and to investigate whether it could be attenuated by the action of polyunsaturated acyl lysophosphatidylcholines (LPCs), which are known as anti-inflammatory lipid mediators.First, saturated acyl LPC was administered intraperitoneally ...
Nguyen Dang, Hung +2 more
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The aim of this study was to examine the inflammation induced by saturated acyl lysophosphatidylcholine (LPC) in vivo and to investigate whether it could be attenuated by the action of polyunsaturated acyl lysophosphatidylcholines (LPCs), which are known as anti-inflammatory lipid mediators.First, saturated acyl LPC was administered intraperitoneally ...
Nguyen Dang, Hung +2 more
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A sensitive, radiometric assay for lysophosphatidylcholine
Analytical Biochemistry, 1990To facilitate investigation of the metabolism of lysophosphatidylcholine and choline lysoplasmalogen in small quantities of tissue, a method for the quantification of these phospholipid species that is capable of accurate and reproducible analysis in samples which contain less than 1 nmol of total choline lysophospholipid was developed.
D J, Dobmeyer, P B, Corr, M H, Creer
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Metabolism of lysophosphatidylcholine by swine platelets
Lipids, 1985AbstractIncubation of intact platelets from Sinclair(S‐1) miniature swine with32P‐labeled lysophosphatidylcholine (lyso PC) indicated the presence of an active lysophospholipase with a pH optimum of 8.0 for hydrolysis of the substrate. However, lyso PC was incorporated into the membrane phosphatidylcholines by the acyltransferase pathway upon addition ...
D E, Chen +3 more
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Acylation of lysophosphatidylcholine by brain membranes
Journal of Neuroscience Research, 1993AbstractBrain microsomes catalyze the acylation of lysophosphatidylcholine (lysoPtdCho) in the presence and absence of added CoA derivatives. The catalytic activity is distributed widely in various subcellular fractions from rat or bovine cerebral cortex as measured by the conversion of 1‐[14C] palmitoyl‐sn‐glycero‐3‐phosphocholine to [14C]PtdCho ...
N, Premkumar, G Y, Sun, R A, MacQuarrie
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Inhibition of Membrane Fusion by Lysophosphatidylcholine
Biochemistry, 1994The ability of lysophosphatidylcholine to inhibit membrane fusion at subsolubilizing concentrations (between 1 and 9 mol % with respect to the membrane lipids) was examined. Fusion between N-methyldioleoylphosphatidylethanolamine (DOPE) large unilamellar vesicles (LUV) and fusion between Sendai virus and N-methyl-DOPE LUV were measured.
P L, Yeagle +3 more
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Lysophosphatidylcholine export by human ABCA7
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017The ATP-binding cassette transporter A7 (ABCA7), which is highly expressed in the brain, is associated with the pathogenesis of Alzheimer's disease (AD). However, the physiological function of ABCA7 and its transport substrates remain unclear. Immunohistochemical analyses of human brain sections from AD and non-AD subjects revealed that ABCA7 is ...
Maiko, Tomioka +8 more
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Lysophosphatidylcholine metabolism and cardiac arrhythmias
Canadian Journal of Physiology and Pharmacology, 1988The ability of exogenous lysophosphatidylcholine (LPC) to produce electrophysiological abnormalities in cardiac tissues and cardiac arrhythmias in isolated hearts has been well documented. In this study, the arrhythmogenic nature of LPC in the rat, rabbit, and guinea pig hearts was studied.
Giffin, M, Arthur, G, Choy, PC, Man, RYK
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Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
Current Medicinal Chemistry, 2007Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid generated by pathological activities. LPC is also a major phospholipid component of oxidized low-density lipoprotein (Ox-LDL) and is implicated as a critical factor in the atherogenic activity of Ox-LDL.
Takayuki, Matsumoto +2 more
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Activation of peritoneal macrophages by lysophosphatidylcholine
Biochimica et Biophysica Acta (BBA) - General Subjects, 1985Lysophosphatidylcholine (lyso-PC), a product of inflammation induced by infectious and other agents, is able to stimulate mouse peritoneal macrophages to ingest target cells coated with IgG but not IgM regardless of the presence of complement. In vitro treatment of mouse resident peritoneal macrophages (adherent cells) alone with lyso-PC stimulated ...
B Z, Ngwenya, N, Yamamoto
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Lysophosphatidylcholine and the inflammatory action of neutrophils
Scandinavian Journal of Clinical and Laboratory Investigation, 1988Lysophosphatidylcholine (lysoPC) is a polar lipid formed in cells and tissues under normal conditions and is known to cause tissue damage in a variety of experimental systems. We have therefore examined the possibility that increased amounts of lysoPC are formed in activated inflammatory cells and are involved in their tissue-damaging action.
M, Lindahl, R, Bruhn, C, Tagesson
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