Results 141 to 150 of about 7,531 (229)
Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1057-1069, April 2026.Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka +12 more
wiley +1 more source
HPLC-MS-Based Metabonomics Reveals Disordered Lipid Metabolism in Patients with Metabolic Syndrome
Journal of Analytical Science and Technology, 2011 Ultra-high performance liquid chromatography/ quadrupole time of flight mass spectrometry-based metabonomics platform was employed to profile the plasma metabolites of patients with metabolic syndrome and the healthy controls. Data analysis revealed lots
Xinjie Zhao +6 more
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Glia, Volume 74, Issue 4, April 2026.Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano +10 more
wiley +1 more source
Purslane (Portulaca oleracea L.) Extract Alleviates Atherosclerosis in ApoE−/− Mice
Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.Oral administration of purslane extract at 400 mg/lg/day for 4 weeks reduces atherosclerotic plaque formation, endothelial dysfunction, and vascular inflammation through suppressing the MAPK pathway and activating AMPK/PI3K/Akt/eNOS pathway in ApoE−/− mice. ABSTRACT Portulaca oleracea L.
Yuehan Wang +5 more
wiley +1 more source
pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma
Acta Physiologica, Volume 242, Issue 4, April 2026.ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab +37 more
wiley +1 more source
TaRIP2 Positively Regulates Wheat Pollen Wall Formation Through MYB80‐Controlled Lipid Metabolism
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2595-2606, April 2026.ABSTRACT Male‐sterile genes and mutants are critical for hybrid seed production in monocotyledonous crops. Lipids are essential structural components of male reproductive organs, such as the anther and pollen. Here, we show that the pollen‐preferential gene TaRIP2 is essential for wheat anther development and pollen formation. RT‐qPCR analysis revealed
Ran Han +14 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Weekly moderate‐to‐vigorous activity (≈6 h) induced a marked increase in ACE promoter methylation in exercised knee‐extensor muscle. In combination with the ACE I/D genotype, ACE methylation contributed to ACE gene activity regulation in ways aligning with the slow‐twitch, aerobic muscle phenotype and its metabolic response to endurance exercise ...
Flück Martin +2 more
wiley +1 more source
High-fat diet feeding differentially affects the development of inflammation in the central nervous system [PDF]
, 2016 core +1 more source
, 2018 Lipid function and importance in disease are being rediscovered due to modern advancements in chemical analysis. RP–UPLC–TOF–MSE is now the lipidomics tool of choice and can provide the demanded specificity for detecting the great diversity of the ...
Vorkas, PA
core +1 more source