Results 211 to 220 of about 7,630 (250)
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Lysophosphatidylcholine Induces Apoptosis in AR42J Cells
Pancreas, 2001Phospholipase A2 (PLA2) has been suggested to play an important role in the pathogenesis of acute pancreatitis, in part through the PLA2-generated phospholipid by-products, most notably lysophosphatidylcholine (lyso-PC). The effects of lyso-PC on pancreatic acinar cells, other than the induction of necrosis, are poorly characterized.
A, Masamune +5 more
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Inhibition of Membrane Fusion by Lysophosphatidylcholine
Biochemistry, 1994The ability of lysophosphatidylcholine to inhibit membrane fusion at subsolubilizing concentrations (between 1 and 9 mol % with respect to the membrane lipids) was examined. Fusion between N-methyldioleoylphosphatidylethanolamine (DOPE) large unilamellar vesicles (LUV) and fusion between Sendai virus and N-methyl-DOPE LUV were measured.
P L, Yeagle +3 more
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[8] Lysophosphatidylcholine acyltransferase
1992Publisher Summary This chapter discusses lysophosphatidylcholine acyltransferase. Lyso-PC:acyl-CoA acyltransferase activity is detected in various mammalian tissues, bacteria, protozoa, and plants. The transfer of acyl groups from acyl-CoA to 1-acylglycerophosphocholine (1-acyl-GPC) is catalyzed by 1-acyl-GPC: acyl-CoA acyltransferase, whereas ...
Patrick C. Paul +2 more
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Lysophosphatidylcholine as a ligand for immunoregulation
Biochemical Pharmacology, 2002Despite the recognized effects of lysophosphatidylcholine upon cells of the immune system and its association with inflammatory processes, its mechanism of action has remained poorly characterized. Our recent identification of the first lysophosphatidylcholine receptor as an immunoregulatory G protein-coupled receptor named G2A whose genetic ablation ...
Janusz H S, Kabarowski +2 more
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Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
Current Medicinal Chemistry, 2007Lysophosphatidylcholine (LPC) is a bioactive proinflammatory lipid generated by pathological activities. LPC is also a major phospholipid component of oxidized low-density lipoprotein (Ox-LDL) and is implicated as a critical factor in the atherogenic activity of Ox-LDL.
Takayuki, Matsumoto +2 more
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Acylation of lysophosphatidylcholine by brain membranes
Journal of Neuroscience Research, 1993AbstractBrain microsomes catalyze the acylation of lysophosphatidylcholine (lysoPtdCho) in the presence and absence of added CoA derivatives. The catalytic activity is distributed widely in various subcellular fractions from rat or bovine cerebral cortex as measured by the conversion of 1‐[14C] palmitoyl‐sn‐glycero‐3‐phosphocholine to [14C]PtdCho ...
N, Premkumar, G Y, Sun, R A, MacQuarrie
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Metabolism of lysophosphatidylcholine by swine platelets
Lipids, 1985AbstractIncubation of intact platelets from Sinclair(S‐1) miniature swine with32P‐labeled lysophosphatidylcholine (lyso PC) indicated the presence of an active lysophospholipase with a pH optimum of 8.0 for hydrolysis of the substrate. However, lyso PC was incorporated into the membrane phosphatidylcholines by the acyltransferase pathway upon addition ...
D E, Chen +3 more
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Increased platelet membrane lysophosphatidylcholine in schizophrenia
Biological Psychiatry, 1991Disturbances in phospholipid metabolism have been suggested in schizophrenia (Rotrosen and Wolkin 1987; Brody et al 1987). There is increasing evidence from numerous studies on blood cells, mostly erythrocytes and platelets, that membrane phospholipid distribution is changed in schizophrenic patients, however, results are not consistent.
A M, Pangerl +4 more
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A sensitive, radiometric assay for lysophosphatidylcholine
Analytical Biochemistry, 1990To facilitate investigation of the metabolism of lysophosphatidylcholine and choline lysoplasmalogen in small quantities of tissue, a method for the quantification of these phospholipid species that is capable of accurate and reproducible analysis in samples which contain less than 1 nmol of total choline lysophospholipid was developed.
D J, Dobmeyer, P B, Corr, M H, Creer
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Activation of peritoneal macrophages by lysophosphatidylcholine
Biochimica et Biophysica Acta (BBA) - General Subjects, 1985Lysophosphatidylcholine (lyso-PC), a product of inflammation induced by infectious and other agents, is able to stimulate mouse peritoneal macrophages to ingest target cells coated with IgG but not IgM regardless of the presence of complement. In vitro treatment of mouse resident peritoneal macrophages (adherent cells) alone with lyso-PC stimulated ...
B Z, Ngwenya, N, Yamamoto
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