Results 11 to 20 of about 11,647 (179)
Cancer Medicine, 2022 Background Numerous studies have investigated the possible involvement of eicosanoids, lysophospholipids, and sphingolipids in cancer. We considered that comprehensive measurement of these lipid mediators might provide a better understanding of their ...
Makoto Kurano, Eri Sakai, Yutaka Yatomi
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Specific inhibition of rat brain phospholipase D by lysophospholipids
Journal of Lipid Research, 2000 Although the importance of phospholipase D (PLD) in signal transduction in mammalian cells is well documented, the negative regulation of PLD is poorly understood. This is primarily due to a lack of known specific inhibitors of PLD. We herein report that
Stephen B. Ryu, Jiwan P. Palta
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Animals, 2020 Lysophospholipids (LPL), a new feed additive, were supplemented to a pelleted total mixed ration (TMR) of dairy cows to examine its effects on feed intake, production, and composition of milk and plasma biochemical parameters.
Yuhua He +5 more
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Lysophospholipid mediators in the vasculature [PDF]
Experimental Cell Research, 2015 Acting through cell surface receptors, “extracellular” lysophosphatidic acid (LPA) influences cell growth, differentiation, apoptosis and development in a wide spectrum of settings [1–5]. Within the vasculature, smooth muscle cells [6, 7], endothelial cells [8] and platelets [9, 10] display notable responses to LPA [11, 12], which likely regulate blood
Paul Mueller +3 more
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Cells, 2022 Systemic inflammation induces alterations in the finely tuned micromilieu of the brain that is continuously monitored by microglia. In the CNS, these changes include increased synthesis of the bioactive lipid lysophosphatidic acid (LPA), a ligand for the
Lisha Joshi +10 more
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Journal of Lipid Research, 2000 A novel solvent system for two-dimensional thin-layer chromatography was shown to simultaneously separate lysophospholipid standards, including lysophosphatidylcholine, lysophosphatidylethanolamine, lysophosphatidylserine, lysophosphatidylinositol ...
Kazukaki Yokoyama +2 more
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Journal of Lipid Research, 2010 LC/ESI-MS/MS has been previously demonstrated to be a powerful method to detect and quantify molecular species of glycerophospholipids including lysophospholipids.
James G. Bollinger +3 more
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Journal of Lipid Research, 1999 Lysophosphatidylcholine (lyso-PC) and arachidonate are products of phosphatidylcholine hydrolysis by phospholipase A2. In this study, the modulation of arachidonate release by exogenous lyso-PC in rat heart myoblastic H9c2 cells was examined.
Leonard S. Golfman +6 more
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Synergy between serum amyloid A and secretory phospholipase A2
eLife, 2019 Serum amyloid A (SAA) is an evolutionally conserved enigmatic biomarker of inflammation. In acute inflammation, SAA plasma levels increase ~1,000 fold, suggesting that this protein family has a vital beneficial role.
Shobini Jayaraman +2 more
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Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007 The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse groups of G-protein-coupled receptors that are widely expressed and regulate decisive cellular functions.
Meyer zu Heringdorf, Dagmar +1 more
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