Results 11 to 20 of about 19,633 (273)
Peptide lipidation in lysophospholipid micelles and lysophospholipid-enriched membranes
Faraday Discussions, 2021 Acyl transfer to a membrane-associated peptide from both lysolipids and lipids occurs readily, leading to the generation of a lipidated peptide that adopts secondary structure in the absence of lipids.
Vian S. Ismail +3 more
openaire +6 more sources
SnapShot: Bioactive Lysophospholipids
Cell, 2012 Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) and sphingosine 1-phosphate (S1P) are bioactive lysophospholipids that regulate critical biological functions and disease processes. LPA and S1P act on distinct G protein-coupled receptors (GPCRs) that initiate multiple signaling cascades in many cell types.
Wouter H. Moolenaar, Timothy Hla
openalex +3 more sources
Specific inhibition of rat brain phospholipase D by lysophospholipids
Journal of Lipid Research, 2000 Although the importance of phospholipase D (PLD) in signal transduction in mammalian cells is well documented, the negative regulation of PLD is poorly understood. This is primarily due to a lack of known specific inhibitors of PLD. We herein report that
Stephen B. Ryu, Jiwan P. Palta
doaj +1 more source
Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. [PDF]
, 2019 Assaying lipolytic enzymes is extremely challenging because they act on water-insoluble lipid substrates, which are normally components of micelles, vesicles, and cellular membranes.
Armando, Aaron +2 more
core +6 more sources
Lysophospholipid mediators in the vasculature [PDF]
Experimental Cell Research, 2015 Acting through cell surface receptors, “extracellular” lysophosphatidic acid (LPA) influences cell growth, differentiation, apoptosis and development in a wide spectrum of settings [1–5]. Within the vasculature, smooth muscle cells [6, 7], endothelial cells [8] and platelets [9, 10] display notable responses to LPA [11, 12], which likely regulate blood
Paul Mueller +3 more
openaire +2 more sources
Secretory Phospholipases A2 in Plants [PDF]
, 2019 Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
Fidelio, Gerardo Daniel +1 more
core +1 more source
Animals, 2020 Lysophospholipids (LPL), a new feed additive, were supplemented to a pelleted total mixed ration (TMR) of dairy cows to examine its effects on feed intake, production, and composition of milk and plasma biochemical parameters.
Yuhua He +5 more
doaj +1 more source
Cells, 2022 Systemic inflammation induces alterations in the finely tuned micromilieu of the brain that is continuously monitored by microglia. In the CNS, these changes include increased synthesis of the bioactive lipid lysophosphatidic acid (LPA), a ligand for the
Lisha Joshi +10 more
doaj +1 more source
Proliferative glioblastoma cancer cells exhibit persisting temporal control of metabolism and display differential temporal drug susceptibility in chemotherapy [PDF]
, 2019 Even in immortalized cell lines, circadian clocks regulate physiological processes in a time-dependent manner, driving transcriptional and metabolic rhythms, the latter being able to persist without transcription.
Gaveglio, Virginia Lucía +6 more
core +1 more source
Journal of Lipid Research, 2010 LC/ESI-MS/MS has been previously demonstrated to be a powerful method to detect and quantify molecular species of glycerophospholipids including lysophospholipids.
James G. Bollinger +3 more
doaj +1 more source