Results 171 to 180 of about 168,690 (311)

Damage control: new functions for the Arp2/3 complex and WHAMM in autophagy and lysosomal homeostasis. [PDF]

Autophagy Rep
Wagner LH, Campellone KG.
europepmc   +1 more source

WDR72 Promotes Neuroblastoma Stemness and Progression by Sequestering TRIM31‐Mediated Degradation of CBX8

Advanced Science, EarlyView.
This study unveiled that METTL14 mediates m6A modification of WDR72 mRNA to stabilize and enhance WDR72 expression, which disrupts TRIM31‐mediated ubiquitination of CBX8 protein and retards its degradation, finally the elevated CBX8 contributes to tumor stemness.
Huijuan Zeng, Zijie Ye, Manna Zheng, Jing Pan, Tianbao Tan, Jiliang Yang, Jiahao Li, Zhang Zhao, Tianzhu Long, Liyu Zhang, Gautam Sethi, Tianyou Yang, Chao Hu, Yan Zou   +13 more
wiley   +1 more source

Self‐Assembly of Antigenic Peptide Nanofibrils Templates the Growth of Silica Nanoparticles for Nanovaccines

Advanced Science, EarlyView.
Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang, Min Li, Zhiying Yao, Yu Hu, Zhili Wang, Wendi Shi, Bingbing Sun   +6 more
wiley   +1 more source

Editorial: Intracellular Mechanisms of α-Synuclein Processing

Frontiers in Cell and Developmental Biology, 2021
Friederike Zunke, Beate Winner, Franziska Richter, Gabriela Caraveo   +3 more
doaj   +1 more source

Astrocytes mobilize a broader repertoire of lysosomal repair mechanisms than neurons. [PDF]

iScience
Smith EM, Chanaday NL, Maday S.
europepmc   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair. [PDF]

Nat Commun
Adeosun OA, Schröer C, Südhoff E, Bergenthal F, Sommer K, Döffinger E, Fiedler B, Hilderink A, Lehmann AK, Pohle LS, Korneev SM, Fröhlich F, Maeda K, Kurre R, Holtmannspötter M, Esch BM, Holthuis JCM.   +16 more
europepmc   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Nerve injury-induced protein 2 preserves lysosomal membrane integrity to suppress ferroptosis. [PDF]

Elife
Zhang J, Bustamante M, Shi Y, Nakajima KI, Chen X.   +4 more
europepmc   +1 more source

The extracellular lysosome [PDF]

Arthritis & Rheumatism, 1981
openaire   +2 more sources