Results 151 to 160 of about 171,488 (262)

ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes. [PDF]

J Cell Biol
Clegg D, Bentley-DeSousa A, Roczniak-Ferguson A, Ferguson SM.   +3 more
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

New insights on iron overload-mediated lysosomal membrane rupture in liver regeneration following acetaminophen-induced liver injury. [PDF]

Explor Dig Dis
Zhu H, Cao P, Ding WX.
europepmc   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

"S-Tau-Lled" Lysosomes Disrupt Autophagic Processes in Neurodegeneration. [PDF]

Traffic
Bécot A, Kabani M.
europepmc   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria. [PDF]

Nat Commun
Yang H, Matsuhisa K, Wei M, Nishi W, Koh DHZ, Sim AY, Bonne I, Saheki Y.   +7 more
europepmc   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol handling. [PDF]

Mol Metab
Verzijl CRC, Barbosa MG, Vos DY, Heida AH, Caillaud A, Vanharanta L, Ge X, Tissink JJ, Koster MH, Smit M, Huijkman N, Kloosterhuis NJ, Girardeau A, Begué-Racapé Z, Bloks VW, Havinga R, Fuh MM, Reggiori F, Mari M, Scheja L, Kuipers F, Solé-Domènech S, Kooijman S, Heeren J, de Boer JF, Rensen PCN, Ikonen E, Rimbert A, Wolters JC, Kuivenhoven JA, van de Sluis B.   +30 more
europepmc   +1 more source