Results 291 to 300 of about 239,873 (360)

Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis. [PDF]

Cell Death Dis
Fu BXH, Xu A, Li H, Johnson DE, Grandis JR, Gilbert LA.   +5 more
europepmc   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Secretome translation shaped by lysosomes and lunapark-marked ER junctions. [PDF]

Nature
Choi H, Liao YC, Yoon YJ, Grimm J, Wang N, Lavis LD, Singer RH, Lippincott-Schwartz J.   +7 more
europepmc   +1 more source

Rod‐Shaped Nanotherapeutics Alleviate Rheumatoid Arthritis by Precisely Disrupting Platelet‐Mediated Pathological Crosstalk via a Morphology‐Dependent Manner

Advanced Science, EarlyView.
Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang, Yuanyi Hua, Xin Wen, Zhumei Liao, Jianheng Ren, Yajun Weng, Qin Wang   +6 more
wiley   +1 more source

Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity. [PDF]

Nat Commun
Li Y, Sheng M, Li W, Liu S, Wang B, Liu B, Luo M, Zhou X, Xia Q, Hong S, Zheng Z, Cheng SY, Jiang X, Li J, Huang T.   +14 more
europepmc   +1 more source

A SPLICS reporter reveals $${{{{{\boldsymbol{\alpha }}}}}}$$-synuclein regulation of lysosome-mitochondria contacts which affects TFEB nuclear translocation

Flavia Giamogante, Lucia Barazzuol, Francesca Maiorca, Elena Poggio, Alessandra Esposito, Anna Masato, Gennaro Napolitano, Alessio Vagnoni, Tito Calí, Marisa Brini   +9 more
openalex   +1 more source

A small-molecule anti-cancer drug for long-acting lysosomal damage. [PDF]

Acta Pharm Sin B
Zhao S, Bai Q, Xue G, Wang J, Hu L, Wang X, Li Y, Lu S, Sun Y, Zhang Z, Mu Y, Zhi Y, Chen Q.   +12 more
europepmc   +1 more source

Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co-Cultured Neurons. [PDF]

J Neurochem
Kaplelach AK, Hall JA, Nader WO, Davidson AG, Ireland MD, Ianov L, Arrant AE.   +6 more
europepmc   +1 more source

Lysosome dysfunction alters intestinal morphology and lipid metabolism in early neonatal piglets. [PDF]

BMC Vet Res
Wang H, Li W, Tao Y, Zhong R, Li Y, Yang H.   +5 more
europepmc   +1 more source