Results 61 to 70 of about 82,606 (197)

Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

Cell Reports, 2019
SUMMARY Neurons face the challenge of maintaining cellular homeostasis through lysosomal degradation. While enzymatically active degradative lysosomes are enriched in the soma, their axonal trafficking and positioning and impact on axonal physiology ...
T. Farfel-Becker, Joseph C Roney, Xiu-Tang Cheng, Sunan Li, Sean R. Cuddy, Zu-Hang Sheng   +5 more
semanticscholar   +1 more source

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR

Journal of Lipid Research, 2012
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that promotes degradation of cell surface LDL receptors (LDLRs) in selected cell types.
Yan Wang, Yongcheng Huang, Helen H. Hobbs, Jonathan C. Cohen   +3 more
doaj   +1 more source

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17

Journal of Cell Biology, 2018
Macroautophagy is an evolutionarily conserved catabolic mechanism that delivers intracellular constituents to lysosomes using autophagosomes. To achieve degradation, lysosomes must fuse with closed autophagosomes.
Takahide Matsui, Peidu Jiang, Saori Nakano, Y. Sakamaki, Hayashi Yamamoto, N. Mizushima   +5 more
semanticscholar   +1 more source

ESC‐sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia

Advanced Science, 2020
Vascular dementia (VD) is one of the most common types of dementia, however, the intrinsic mechanism is unclear and there is still lack of effective medications.
Guowen Hu, Yuguo Xia, Juntao Zhang, Yu Chen, Ji Yuan, Xin Niu, Bizeng Zhao, Qing Li, Yang Wang, Zhifeng Deng   +9 more
doaj   +1 more source

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

Nature Communications, 2016
Cellular stresses trigger autophagy to remove damaged macromolecules and organelles. Lysosomes ‘host’ multiple stress-sensing mechanisms that trigger the coordinated biogenesis of autophagosomes and lysosomes.
Xiaoli Zhang, Xi-ping Cheng, Lu Yu, Junsheng Yang, Raul Calvo, S. Patnaik, Xin Hu, Qiong Gao, Meimei Yang, M. Lawas, M. Delling, J. Marugan, M. Ferrer, Haoxing Xu   +13 more
semanticscholar   +1 more source

Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.

Trends in Cell Biology, 2019
Lysosomes are sites of active metabolism in a cell. They contain various hydrolases that degrade extracellular and intracellular materials during endocytosis and autophagy, respectively.
Marzia Savini, Qian Zhao, Meng C. Wang
semanticscholar   +1 more source

Lnc-HIBADH-4 regulates autophagy-lysosome pathway in amyotrophic lateral sclerosis by targeting Cathepsin D [PDF]

, 2023
Jingxuan Huang, Yujiao Yu, Dejiang Pang, Chunyu Li, Qianqian Wei, Yangfan Cheng, Yiyuan Cui, Ruwei Ou, Huifang Shang   +8 more
openalex   +1 more source

Mitochondrial–Lysosomal Axis in Acetaminophen Hepatotoxicity

Frontiers in Pharmacology, 2018
Acetaminophen (APAP) toxicity is the most common cause of acute liver failure and a major indication for liver transplantion in the United States and Europe. Although significant progress has been made in understanding the molecular mechanisms underlying
Anna Moles, Anna Moles, Sandra Torres, Sandra Torres, Anna Baulies, Anna Baulies, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa, Jose C. Fernandez-Checa   +11 more
doaj   +1 more source

Correction to “Microglial LRRK2‐mediated NFATc1 attenuates α‐synuclein immunotoxicity in association with CX3CR1‐induced migration and the lysosome‐initiated degradation” [PDF]

, 2023

openalex   +1 more source

Cholesterol delivered to macrophages by oxidized low density lipoprotein is sequestered in lysosomes and fails to efflux normally

Journal of Lipid Research, 2000
Oxidized low density lipoprotein (LDL) has been found to exhibit numerous potentially atherogenic properties, including transformation of macrophages to foam cells.
Baljinder S. Dhaliwal, Urs P. Steinbrecher   +1 more
doaj   +1 more source