Results 61 to 70 of about 239,873 (360)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties

Frontiers in Cell and Developmental Biology
Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion.
Julie Patat, Kristine Schauer, Kristine Schauer, Hugo Lachuer   +3 more
doaj   +1 more source

Effect of photosensitizers photosens, photodithazine and hypericin on glioma cells and primary neuronal cultures : a comparative analysis [PDF]

, 2019
The aim of the study was to compare the effect of photosensitizers photosens, photodithazine, and hypericin on primary brain cell cultures, and assess their toxic effect on tumor and normal nervous cells in order to choose the optimal photodynamic agent ...
Alzeibak, Rozan, Balalaeva, irina, Krysko, Dmitri, Mishchenko, Tatiana, Mitroshina, Elena, Turubanova, Viktoria, Vedunova, Maria   +6 more
core   +2 more sources

Lysosomal Storage Diseases

Translational Science of Rare Diseases, 2016
Lysosomes are cytoplasmic organelles that contain a variety of different hydrolases. A genetic deficiency in the enzymatic activity of one of these hydrolases will lead to the accumulation of the material meant for lysosomal degradation. Examples include glycogen in the case of Pompe disease, glycosaminoglycans in the case of the mucopolysaccharidoses,
Ferreira, Carlos R., Gahl, William A.
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular Mechanisms of Autophagy Decline during Aging

Cells
Macroautophagy (hereafter autophagy) is a cellular recycling process that degrades cytoplasmic components, such as protein aggregates and mitochondria, and is associated with longevity and health in multiple organisms.
Shaun H. Y. Lim, Malene Hansen, Caroline Kumsta   +2 more
doaj   +1 more source

Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells [PDF]

, 2018
Estrogen receptor α (ERα) is expressed in tissues as diverse as brains and mammary glands. In breast cancer, ERα is a key regulator of tumor progression.
Acconcia, Acconcia, Acerbi, Adlanmerini, Alfredo Cáceres, Ambrose, Andrés M. Toscani, Arjonen, Arnal, Axelrod, Axelrod, Bacia, Bae, Barabas, Bates, Bermudez-Hernandez, Bonifacino, Bradford, Cancer Genome Atlas Network, Caswell, Cerami, Chaumet, Chung, Ciriello, Ciriello, Correia, Cosker, Cosker, Couse, Cox, Dante R. Chialvo, De Franceschi, Debnath, Degasperi, Delcroix, Dozynkiewicz, Dunn, Eirew, Federico Coluccio Leskow, Fernando D. Stefani, Gao, Gao, Ghajar, Gillespie, Gould, Graham, Grant, Han, Han, Hartley, He, Heery, Helleman, Hernández, Hines, Honerkamp-Smith, Ianina L. Violi, Jeselsohn, Johnson, Jonathon N. Lakins, Kate Thi, Kisler, La Rosa, Letoha, Levin, Li, Long, Lu, Lu, Luciano A. Masullo, Luzio, Mak, Marina Simian, Marino, Matthew G. Rubashkin, Mayor, Mayor, Małecki, McDonough, Mina J. Bissell, Moreno-Layseca, Nam, Nardone, Nicovich, Ovesný, Pedram, Pereira, Pietras, Pontiggia, Razandi, Reid, Rocío G. Sampayo, Rust, Savkur, Schindelin, Schlegel, Skliris, Solowska, Su, Sung, Takahashi, Tiwari, Totta, Totta, Upla, Valerie M. Weaver, van de Linde, Vanlandingham, Wang, Waxmonsky, William C. Hines, Yao   +111 more
core   +2 more sources

Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model [PDF]

, 2020
Alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (pTAU), tau aggregation and neurofibrillary tangle formation sequentially ...
Carmans, Sofie, de Vries, Helga E., Franssen, Marc, Kamermans, Alwin, Popovic, Marko, Roucourt, Bart, Schouten, Marijn, Sobrino, Tomás, van der Pol, Susanne M.A., van Olst, Lynn, Vandenbroucke, Roosmarijn, Verhaege, Daan, Wever, Dennis, Ytebrouck, Ellen   +13 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders

Biomolecules
Dysfunction of the lysosome and autophagy–lysosome pathway is closely associated with various diseases, such as neurodegenerative diseases, non-alcoholic fatty liver disease (NAFLD), etc.
Yuanjing Hao, Xinru Fan, Xiaodan Huang, Zhaoying Li, Zhiyuan Jing, Guilong Zhang, Yuxue Xu, Na Zhang, Pengfei Wei   +8 more
doaj   +1 more source