Results 71 to 80 of about 158,743 (267)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Permeability properties of rat renal lysosomes
, 1994 Although lysosomes maintain large pH gradients and may be subjected to significant osmotic gradients in vivo, little is known about their passive permeability properties. In recent studies, vacuolar H(+)-adenosine-triphosphatases (ATPases), such as those
M. Somers +6 more
core +1 more source
Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells [PDF]
, 2012 Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous studies established the ability of CNTs to enter cells and their therapeutic utility, but an ...
Silva, S. Ravi P. +17 more
core +1 more source
The Emerging Role of the Lysosome in Parkinson’s Disease
Cells, 2020 Lysosomal function has a central role in maintaining neuronal homeostasis, and, accordingly, lysosomal dysfunction has been linked to neurodegeneration and particularly to Parkinson’s disease (PD).
Alba Navarro-Romero +2 more
doaj +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Epidermal Lysosomes and Ultraviolet Light*
, 1974 Secondary lysosomes of guinea-pig keratinocytes were labeled, in vivo, with an electron microscopic marker (Thorotrast) that can he identified both within stable lysosomes and, after lysosome lysis, in extralysosomal locations.
Hönigsmann, Herbert +5 more
core +1 more source
Activity-dependent trafficking of lysosomes in dendrites and dendritic spines [PDF]
, 2017 In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily reside in somatic and axonal compartments, but there is little understanding of their distribution and function in dendrites.
Natalia Slepak +15 more
core +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Degradation of Htt-552 by lysosomes.
, 2012 (A) The purity of the isolated lysosomes. Total cellular homogenates and lysosomal fraction (30 µg of proteins) were subjected to SDS-PAGE and immunoblotting for the indicated proteins. Actin was shown as a marker of cytoplasm.
Fang Lin (128232) +6 more
core +1 more source