Results 61 to 70 of about 158,743 (267)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Liver lysosomes in protein-starved rats
, 1969 1. The feeding of a protein-free diet to adult rats trained to consume their whole day's food in 2 h changed the characteristics of hepatic lysosomes immediately upon the onset of protein deficiency combined with calorie deficiency. 2.
Saroja, S. +5 more
core +1 more source
Degradation of Melanosomes by Lysosomes
, 1971 The degradation of melanosomes by the lysosomes of the mouse liver was studied in vitro. Mice with melanoma received intraperitoneal injections of a 14C-amino acid mixture and 14C-dopa separately.
N. Ohtaki +3 more
core +1 more source
eLife, 2018 Drugs called bisphosphonates are used to treat a range of bone diseases, but how do they reach the enzymes that are their target?
Michael J Rogers, Marcia A Munoz
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Are Melanosome Complexes Lysosomes?
, 1972 The formation of secondary lysosomes was induced in keratinocytes of guinea pig skin. Lysosomes labeled by an electron microscopic tracer (Thorotrast) were observed to fuse with and spill their contents into melanosome complexes and membrane bound single
Hönigsmann, Herbert, Wolff, Klaus
core +1 more source
eLife, 2017 Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis.
Rodney Elwood Infante +1 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Macroautophagy/autophagy is an essential pro-survival mechanism activated in response to nutrient deficiency. The proper fusion between autophagosomes and lysosomes is a critical step for autophagic degradation.
Zhou, C. +6 more
core +1 more source
Analysis of protein transport to lysosomes
, 2005 Lysosomes are terminal degradative organelles that are found in all higher eukaryotic cells. The biogenesis of lysosomes involves the transport of various acid hydrolases and transmembrane glycoproteins from their site of synthesis in the endoplasmic ...
Beat E. Schaub +5 more
core +1 more source