Results 81 to 90 of about 26,398 (197)

S1‐Guideline for diagnosis and therapy of necrobiosis lipoidica

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 3, Page 429-436, March 2026.
Summary Necrobiosis lipoidica (NL) is a rare granulomatous skin disease of unknown etiology that occurs frequently in association with diabetes mellitus and other comorbidities. The predilection site is the lower leg, particularly the pretibial areas. The exact pathogenesis remains unclear.
Cornelia Erfurt‐Berge   +6 more
wiley   +1 more source

Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP‐1

open access: yesGenes to Cells, Volume 31, Issue 2, March 2026.
Senescent fibroblasts construct collagen fibrils, whose orientation is disturbed. We found that senescent fibroblasts downregulate C‐pp cleavage enzymes BMP‐1 and PCPE‐1, which results in downregulation of C‐pp cleavage. This was demonstrated by conducting BMP‐1 knockdown experiments in young fibroblasts, which led to a disturbance in the orientation ...
Koji Moriya   +3 more
wiley   +1 more source

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

open access: yes, 2020
Arterial tortuosity syndrome (ATS) is a recessively inherited connective tissue disorder, mainly characterized by tortuosity and aneurysm formation of the major arteries.
Barnhoorn, Sander   +14 more
core   +1 more source

Structural characterization of newt tendon regeneration after complete transection: In vivo two‐photon imaging and transmission electron microscopy

open access: yesJournal of Anatomy, Volume 248, Issue 3, Page 383-394, March 2026.
The present study characterized newt digital flexor tendon regeneration structurally at both micro‐ and nanoscales following complete transection and suggested that the mechanism of tissue regeneration differs between the early phase (until 6 weeks) and the late phase (after 6 weeks). Tendon stubs remained separated for up to 2 weeks after transection,
Tomoka Kamiya   +7 more
wiley   +1 more source

LOX and LOXL2 Expression in Canine Mammary Carcinomas

open access: yesVeterinary and Comparative Oncology, Volume 24, Issue 1, Page 160-166, March 2026.
ABSTRACT Mammary tumours account for approximately 50% of the neoplasms in female dogs. Even conventionally accepted prognostic indicators often fail to reliably predict the clinical behaviour of these tumours, underscoring the need for more effective prognostic markers.
Jessika Daniel   +6 more
wiley   +1 more source

Incisional Hernia Development: Wound Healing Gone Wrong?

open access: yesWound Repair and Regeneration, Volume 34, Issue 2, March/April 2026.
ABSTRACT Incisional hernia (IH) is a common complication of abdominal surgeries, characterised by the protrusion of abdominal contents through a weakened surgical scar. Despite advancements in surgical techniques and biomaterials, IH remains a significant clinical and economic burden, with recurrence rates reaching up to 32% after repair.
Asim A. Abbas   +3 more
wiley   +1 more source

How reliable and robust are current biomarkers for copper status? [PDF]

open access: yes, 2017
Cu is an essential nutrient for man, but can be toxic if intakes are too high. In sensitive populations, marginal over- or under-exposure can have detrimental effects.
Araya, Magdalena   +6 more
core  

Frontiers of antifibrotic therapy in systemic sclerosis [PDF]

open access: yes, 2017
Although fibrosis is becoming increasingly recognized as a major cause of morbidity and mortality in modern societies, targeted anti-fibrotic therapies are still not approved for most fibrotic disorders. However, intense research over the last decade has
Abraham, DJ   +5 more
core  

Lysyl oxidase (LOX) [PDF]

open access: yesScience-Business eXchange, 2011
openaire   +1 more source

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