Results 111 to 120 of about 432,438 (233)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Radiothérapie hypofractionnée en conditions stéréotaxiques des métastases cérébrales de l'adulte (étude rétrospective nantaise de 54 patients présentant une à trois métastases)

, 2009
Cette étude rétrospective étudie la place de la radiothérapie hypofractionnée en conditions stéréotaxiques dans la prise en charge des métastases cérébrales de l'adulte.
MERVOYER, Augustin, THILLAYS, François
core  

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Métastases vertébrales

Ce chapitre couvre la prise en charge des lésions métastatiques osseuses ou péridurales vertébrales survenant dans le décours d’un cancer, quel que soit son site d’origine. Par définition, une métastase se forme suite à l’essaimage à distance de cellules
Banse, Xavier, Lecouvet, Frédéric, Kaminski, Ludovic, Mazzeo, Filomena   +3 more
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Un modèle de métastases pulmonaires spontanées fluorescentes et son utilisation dans l'étude des gènes

, 2004
L'existence de métastases rend difficile le traitement chirurgical définitif des cancers ou leur éradication par radiothérapie localisée. La détermination des bases moléculaires du développement métastatique représente donc une étape cruciale dans la ...
PARIS, Sébastien, FREBOURG, Thierry
core  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Multiparametric MRI characteristics for differentiating primary cancer origin in brain metastases

BMC Medical Imaging
Background Accurate identification of primary cancer origin in brain metastases (BMs) is crucial for diagnosis and treatment planning. Identification is challenging, particularly in unknown primary cases.
Ali Salbas, Mehmet Coskun, Yusuf Kenan Cetinoglu, Merve Horoz, Murat Yogurtcu, Anil Huvez, Mustafa Fazil Gelal   +6 more
doaj   +1 more source

Approche expérimentale du traitement local des métastases hépatiques : hyperfréquence, thérapie photodynamique, modèles animaux

, 2005
Non disponible / Not availableL'ablathermie par radiofréquence (RF) est une technique de destruction locale des tumeurs hépatiques. La morbidité de la RF est faible mais il persiste des situations pour lesquelles la RF est contre indiquée comme la ...
Marchal, Frédéric
core  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source